Syk
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| FB16041 | TAK-659 | 1312691-33-0 | TAK-659 is a highly potent, selective, reversible and orally available dual inhibitor of spleen tyrosine kinase (SYK) and fms related tyrosine kinase 3 (FLT3), with an IC50 of 3.2 nM and 4.6 nM for SYK and FLT3, respectively. TAK-659 induces cell death in tumor cells but not in nontumor cells, and with potential for the treatment of chronic lymphocytic leukemia (CLL)[1][2][3][4]. |
| FB11294 | TAK-659 HCl | 1952251-28-3 | TAK-659 HCl is a selective inhibitor of spleen tyrosine kinase (Syk) with IC50 of 3.2 nM. |
| FB11254 | SYK Inhibitor II | 227449-73-2 | SYK inhibitor II is an inhibitor of SYK. |
| FB18842 | SRX3207 | 2254693-15-5 | SRX3207 is an orally active dual Syk/PI3K inhibitor with IC50 value of 30nM for Syk. It potently blocks phosphorylation of Syk at 348 site and Y525/526 site. SRX3207 reduced immunosuppressive macrophage polarization and increased infiltration and cytotoxicity of CD8+ T cells in LLC tumors and increased expression of Ifng and Gzmb in 3207 treated LLC tumors. |
| FB10138 | RO9021 | 1446790-62-0 | RO9021 potently inhibits SYK kinase activity with an average IC50 of 5.6 nM and suppresses B-cell receptor signaling. |
| FB01935 | R788 Disodium | 1025687-58-4 | R788 disodium, the disodium form of R788, is a Syk inhibitor with IC50 of 41 nM. |
| FB08943 | Fostamatinib 2Na 6H2O | 914295-16-2 | R788 Disodium is a Syk inhibitor with IC50 of 41 nM. It is the prodrug of metabolite R406 with immunomodulatory activity. |
| FB01812 | R406 | 841290-80-0 | R406 is an inhibitor of Syk with IC50 of 41 nM. |
| FB01547 | R406 Benzenesulfonate | 841290-81-1 | R406 benzenesulfonate is a selective inhibitor of Syk with IC50 of 41 nM. |
| FB06197 | R112 | 575474-82-7 | R112, an ATP-competitive inhibitor, can inhibit Syk kinase with Ki of 96 nM. |
| FB07427 | PRT062607 | 1370261-96-3 | PRT062607 is a highly specific and potent inhibitor of Syk with IC50 of 1-2 nM with > 80-fold selectivity for Syk than Fgr, Lyn, FAK, Pyk2 and Zap70. |
| FB01546 | PRT062607 HCl | 1370261-97-4 | PRT062607 HCl is an inhibitor of SYK with IC50 of 1 nM. |
| FB10196 | PRT060318 2HCl | N/A | PRT060318 2HCl is a selective inhibitor of the Syk tyrosine kinase, as an approach to HIT treatment. |
| FB00602 | PRT-060318 | 1194961-19-7 | PRT-060318 is an inhibitor of Syk with IC50 of 4 nM. It is used to treat heparin-induced thrombocytopenia (HIT). |
| FB02123 | Piceatannol | 10083-24-6 | Piceatannol, a natural stilbene, is selective Syk inhibitor extracted from the rhizomes of Polygonum cuspidatum Sieb. et Zucc.. |
| FB12495 | OXSI 2 | 622387-85-3 | OXSI 2 is a potent Syk kinase inhibitor with IC50 of 14 nM, and also inhibits assembly of NLRP3 inflammasomes induced by Nigericin. |
| FB04796 | GS-9973 | 1229208-44-9 | GS-9973 is a Syk inhibitor with IC50 value of 7.7 nM which is used for the treatment of autoimmune and oncology indications. |
| FB08322 | Fostamatinib | 901119-35-5 | Fostamatinib, a prodrug of the active metabolite R406, is a potent Syk inhibitor with IC50 of 41 nM. |
| FB12193 | ER 27319 Maleate | 1204480-26-1 | ER 27319 Maleate is a selective inhibitor of Syk kinase. |
| FB03359 | BAY 61-3606 2HCl | 648903-57-5 | BAY-61-3606 is a potent and selective inhibitor of Syk kinase (Ki = 7.5 nM). |
| FB06267 | BAY 61-3606 | 732983-37-8 | BAY 61-3606 is a potent, ATP-competitive, reversible, and highly selective inhibitor of Syk tyrosine kinase activity (Ki= 7.5 nM) with no inhibitory effect against Btk, Fyn, Itk, Lyn, and Src. |