CCR
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| FB00888 | Vicriviroc Maleate | 599179-03-0 | Vicriviroc maleate is a CCR5 antagonist with IC50 of 0.91 nM in clinical development for the treatment of HIV-1. |
| FB06253 | Vercirnon | 698394-73-9 | Vercirnon is a highly potent antagonist of CCR9, which has been implicated in the aetiology of inflammatory bowel diseases such as Crohn's disease. |
| FB00094 | TAK-220 | 333994-00-6 | TAK-220 is an orally bioavailable small-molecule CCR5 antagonist. |
| FB12148 | SB297006 | 58816-69-6 | SB297006 is a selective antagonist of CCR3 with IC50 of 39 nM. |
| FB04872 | RS-102895 | 300815-41-2 | RS102895 is a potent and specific CCR2 antagonist with binding IC50 of 360 nM, no significant inhibition on CCR1 (IC50 > 17 μM). |
| FB00030 | RS-102895 HCl | 1173022-16-6 | RS102895 HCl is a potent and specific CCR2 antagonist with binding IC50 of 360 nM, no significant inhibition on CCR1 (IC50 > 17 μM). |
| FB07430 | RS-504393 | 300816-15-3 | RS 504393 is a selective CCR2 chemokine receptor antagonist (IC50 values are 98 nM and > 100 μM for inhibition of human recombinant CCR2b and CCR1 receptors respectively). |
| FB12717 | Teijin Compound 1 | 1313730-14-1 | Potent CCR2b antagonist |
| FB12660 | SB 328437 | 247580-43-4 | Potent and selective CCR3 antagonist |
| FB18853 | PF-4136309 | 857679-55-1 | PF-4136309 is an orally available CCR2 antagonist with potential immunomodulating and antineoplastic activities. |
| FB02760 | PF-4136309 | 1341224-83-6 | PF-4136309 is a potent, Selective, and orally bioavailable CCR2 antagonist. |
| FB03174 | NSC 5844 | 140926-75-6 | NSC 5844 is a bisquinoline compound with C-C chemokine receptor type 1 (CCR1)-agonistic properties. |
| FB10303 | MK-0812 Succinate | 851916-42-2 | MK-0812 succinate is a potent and selective CCR2 antagonist with low nM affinity for CCR2 on human monocytes. |
| FB03547 | MK-0812 | 624733-88-6 | MK-0812 is a potent and selective CCR2 antagonist with low nM affinity for CCR2 on human monocytes. |
| FB03895 | Maraviroc | 376348-65-1 | Maraviroc is a selective CCR5 antagonist (IC50= 6.4 nM) and displays potent anti-HIV-1 activity. |
| FB02689 | INCB3344 | 1262238-11-8 | INCB3344 is a potent and selective small molecule antagonist of the mouse CCR2 receptor and inhibits the binding of CCL2 to mouse monocytes with nanomolar potency (IC50 = 10 nM). |
| FB00069 | INCB 3284 Dimesylate | 887401-93-6 | INCB 3284 is a potent, selective and orally bioavailable hCCR2 antagonist with IC50 of 3.7 nM. |
| FB06898 | INCB 3284 | 887401-92-5 | INCB 3284 is a potent, selective and orally bioavailable hCCR2 antagonist with IC50 of 3.7 nM (inhibition of monocyte chemoattractant protein-1 binding to hCCR2). |
| FB11808 | GW 766994 | 408303-43-5 | GW 766994 is a specific and oral chemokine receptor-3 (CCR3) antagonist, which has entered clinical trial for asthma and eosinophilic bronchitis. |
| FB11854 | GSK2239633A | 1240516-71-5 | GSK2239633A is a CC-chemokine receptor 4 (CCR4) antagonist, which inhibits the binding of [125I]-TARC to human CCR4 with a pIC50 of 7.96 ± 0.11. |
| FB12600 | DAPTA | 106362-34-9 | DAPTA is a potent and selective CCR5 antagonist. |
| FB08818 | Cenicriviroc | 497223-25-3 | Cenicriviroc is an oral, dual CCR2/CCR5 antagonist, and displays potent anti-inflammatory and aninfective activity. |
| FB11797 | CCR5 Antagonist 1 | 716354-86-8 | CCR5 antagonist 1 is a CCR5 antagonist which can inhibit HIV replication extracted from WO 2004054974 A2. |
| FB12280 | C 021 2HCl | 1784252-84-1 | C 021 2HCl is a potent CCR4 chemokine receptor antagonist. |
| FB04090 | BX471 | 217645-70-0 | BX471 is a potent, selective non-peptide CCR1 antagonist (Ki = 1 nM for human CCR1) and exhibits 250-fold selectivity for CCR1 over CCR2, CCR5 and CXCR4. |
| FB04863 | BX471 HCl | 288262-96-4 | BX471 HCl is a potent, selective non-peptide CCR1 antagonist (Ki = 1 nM for human CCR1) and exhibits 250-fold selectivity for CCR1 over CCR2, CCR5 and CXCR4. |
| FB12293 | BX 513 HCl | 1216540-18-9 | BX 513 HCl is selective CCR1 receptor antagonist with Ki of 0.04. |
| FB12549 | BMS CCR2 22 | 445479-97-0 | BMS CCR2 22 is a high affinity CCR2 chemokine receptor antagonist with IC50 of 5.1 nM. |
| FB11315 | AZD-2098 | 566203-88-1 | AZD2098 is a potent CC-chemokine receptor 4 (CCR4) inhibitor, used for asthma research. |
| FB11316 | AZD-1678 | 942137-41-9 | AZD1678 is a potent CC-chemokine receptor 4 (CCR4) inhibitor, used for asthma research. |