IAP
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| FB03408 | UC-112 | 383392-66-3 | UC-112 is a potent IAP (Inhibitor of apoptosis) inhibitor, and potently inhibits cell growth in two human melanoma (A375 and M14) and two human prostate (PC-3 and DU145) cancer cell lines (IC50=0.7-3.4 μM). |
| FB11108 | SNIPER(AR)-51 | 2113688-43-8 | SNIPER(AR)-51, a specific and nongenetic inhibitor of apoptosis protein [IAP]-dependent protein erasers (SNIPERs), recruits IAP ubiquitin ligases to degrade target protein, the androgen receptor (AR). |
| FB07165 | SM-164 | 957135-43-2 | SM-164 is a potent cell-permeable and bivalent Smac mimetic which bind to a XIAP protein with a Ki value of 0.56 nM, and binds to cIAP-1 and cIAP-2 proteins with Ki values of 0.31 and 1.1 nM, respectively. |
| FB01124 | LCL161 | 1005342-46-0 | LCL161 is an IAP inhibitor, inhibits XIAP activity in HEK293 cell with IC50 of 35 nM, also inhibits cIAP1 activity in MDA-MB-231 cell with IC50 of 0.4 nM. |
| FB06884 | GDC-0152 | 873652-48-3 | GDC-0152 is a potent inhibitor of IAPs and binds to the XIAP BIR3 domain, the BIR domain of ML-IAP, and the BIR3 domains of cIAP1 and cIAP2 with K (i) values of 28, 14, 17, and 43 nM, respectively. |
| FB01294 | Embelin | 550-24-3 | Embelin, a quinone isolated from the Japanese Ardisia herb, is an inhibitor of X-linked inhibitor of apoptosis (XIAP) with IC50 of 4.1 μM in a cell-free assay. |
| FB03240 | CUDC-427 | 1446182-94-0 | CUDC-427 is a small-molecule peptide mimetic of SMAC/DIABLO and directly antagonizes inhibitors of apoptosis proteins (IAPs). |
| FB01913 | BV-6 | 1001600-56-1 | BV6 is a small-molecule Smac mimetic, which antagonizes IAP and induces autoubiquitination and subsequent proteasomal degradation of cIAP1 and cIAP2. |
| FB10189 | BV-6 Trifluoroacetate | N/A | BV-6 trifluoroacetate is a SMAC mimetic, dual cIAP and XIAP inhibitor. |
| FB02685 | Birinapant | 1260251-31-7 | Birinapant binds with XIAP and cIAP1 with K of 45 and <1 nM, respectively. |
| FB02682 | AZD5582 | 1258392-53-8 | AZD5582 is a class of dimeric Smac mimetics as potent IAP antagonist and binds potently to the BIR3 domains of cIAP1, cIAP2, and XIAP (IC50 = 15, 21, and 15 nM, respectively). |
| FB08601 | AT406 | 1071992-99-8 | AT406 is a potent and orally bioavailable Smac mimetic and an antagonist of the inhibitor of apoptosis proteins (IAPs), AT-406 binds to XIAP, cIAP1, and cIAP2 proteins with K (i) of 66.4, 1.9, and 5.1 nM, respectively. |
| FB11062 | AT-IAP | 1403898-55-4 | AT-IAP is a potent, orally bioavailable, dual antagonist of XIAP and cIAP1 which is functioning in anti-apoptotic and pro-survival signaling pathways. |
| FB11531 | ASTX660 | 1799328-86-1 | An orally bioavailable, non-peptidomimetic antagonist of both X chromosome-linked inhibitor of apoptosis protein (XIAP) and cellular IAP 1 (cIAP1), with potential antineoplastic and pro-apoptotic activities. |