CRM1
货号 | 产品名 | CAS号 | 信息 |
---|---|---|---|
FB02829 | Verdinexor | 1392136-43-4 | Verdinexor is an orally bioavailable selective inhibitor of nuclear export (SINE), inhibits nuclear export protein Exportin 1 (XPO1/CRM1) against canine tumor cell lines and also reduce influenza virus replication in vitro and in vivo. |
FB03377 | Leptomycin B | 87081-35-4 | Leptomycin B is an inhibitor of the nuclear export of proteins which acts by binding directly to and inhibiting CRM1/exportin-1. Leptomycin B inhibits the nuclear export of the HIV regulatory protein Rev and stabilizes p53, showing antiviral, antibiotic, antifunal and antitumor in vitro and in vivo. |
FB10391 | KPT-8602 Z-Isomer | 1642300-78-4 | KPT-8602 Z-isomer is an isomer of KPT-8602, which is highly specific for XPO1 inhibition and demonstrates potent anti-leukemic activity. |
FB10390 | KPT-8602 | 1642300-52-4 | KPT-8602 is a second-generation and oral acitve exportin-1 (XPO1/CRM1) inhibitor with IC50 of 20−211 nM in 10 AML cell lines. |
FB05342 | KPT-330 | 1393477-72-9 | KPT-330, analog of KPT-185, is an orally bioavailable selective CRM1 inhibitor. |
FB03196 | KPT-276 | 1421919-75-6 | KPT-276, analog of KPT-185, is a CRM1 blocker and acts as an orally bioavailable selective inhibitor of nuclear export (SINE) by irreversibly binding to CRM1. |
FB02749 | KPT-185 | 1333151-73-7 | KPT-185 is a selective CRM1 inhibitor that induces growth inhibition and apoptosis in a panel of NHL cell lines with a median IC50 ~25 nM. |