IGF-1R
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| FB06914 | XL228 | 898280-07-4 | XL228 is a protein kinase inhibitor targeting IGF1R, the Aurora kinases, FGFR1-3, ABL and SRC family kinases. |
| FB09557 | PQ401 | 196868-63-0 | PQ401, a selective insulin-like growth factor-1 receptor blocker, is a diarylurea compound that inhibits IGF1R autophosphorylation with IC50 < 1 μM. |
| FB04609 | Picropodophyllin | 477-47-4 | Picropodophyllotoxin is an orally active insulin-like growth factor-1 receptor (IGF-1R) inhibitor with IC50 of 1 nM, and exhibits little effect towards IR, FGFR, PDGFR and EGFR, and exerts no effects on microtubules and DNA topoisomerase II. |
| FB06151 | NVP-AEW541 | 475489-16-8 | NVP-AEW541 is a potent inhibitor of IGF-1R with IC50 of 86 nM, 27-fold greater selectivity for IGF-1R than InsR. |
| FB07007 | NVP-ADW742 | 475488-23-4 | NVP-ADW742 is an selective IGF-1R inhibitor with IC50 of 0.17 μM, > 16-fold more potent against IGF-1R than InsR and shows little activity to HER2, PDGFR, VEGFR-2, Bcr-Abl and c-Kit. |
| FB08324 | NT157 | 1384426-12-3 | NT157 treatment resulted in dose-dependent inhibition of IGF1R activation, suppression of IRS protein expression, inhibition of IGF1-induced AKT activation, but increased ERK activation in NT157-treated cells in vitro. |
| FB08928 | Linsitinib | 867160-71-2 | Linsitinib is highly potent, orally efficacious and highly selective, dual ATP-competitive inhibitor of IGF-1R (IC50= 35 nM) and insulin receptor (IC50=75 nM). |
| FB12132 | Insulin, Human | 11061-68-0 | Insulin, Human is a two-chain polypeptide hormone produced by the β-cells of pancreatic islets, it regulates the cellular uptake, utilization, and storage of glucose, amino acids, and fatty acids and inhibits the breakdown of glycogen, protein, and fat. |
| FB15233 | Insulin, Bovine | 11070-73-8 | Insulin, Bovine is a two-chain polypeptide hormone produced by the β-cells of pancreatic islets, it regulates the cellular uptake, utilization, and storage of glucose, amino acids, and fatty acids and inhibits the breakdown of glycogen, protein, and fat. |
| FB02247 | GSK1904529A | 1089283-49-7 | GSK1904529A is a selective inhibitor of IGF-1R and IR with IC50 of 27 nM and 25 nM, being > 100-fold selective for IGF-1R/InsR than Akt1/2, Aurora A/B,B-Raf, CDK2, EGFR etc. |
| FB08546 | GSK1838705A | 1116235-97-2 | GSK1838705A is a potent small-molecule IGF-IR, the insulin receptor and anaplastic lymphoma kinase (ALK) inhibitor with IC50 of 2.0, 1.6 and 0.5 nM, respectively. |
| FB08593 | BMS-754807 | 1001350-96-4 | BMS-754807 is a potent and reversible inhibitor of IGF-1R/InsR with IC50 of 1.8 nM/1.7 nM, less potent to Met, Aurora A/B, TrkA/B and Ron, and shows little activity to Flt3, Lck, MK2, PKA, PKC etc. |
| FB11760 | AZ7550 Mesylate | N/A | AZ7550 Mesylate is an active metabolite of AZD9291 and inhibits the activity of IGF1R with an IC50 of 1.6 μM. |
| FB09458 | AG1024 | 65678-07-1 | AG1024 inhibits IGF-1R autophosphorylation with IC50 of 7 μM, less potent to IR with IC50 of 57 μM. |