CAS:22071-15-4Ketoprofen

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Ketoprofen 酮基布洛芬 Cat No. FB03104Cas No. 22071-15-4

Synonyms: RP-19583

Ketoprofen is a dual COX1/2 inhibitor with IC50 of 0.5 μM and 2.33 μM for human recombinant COX-1 and COX-2, respectively, and used as a nonsteroidal anti-inflammatory drug (NSAID) to treat arthritis-related inflammatory pains.

规格	价格	促销价格	库存

18817579266

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18817579266

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实验数据

储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.9327 mL
- 19.6634 mL
- 39.3267 mL
- 5 mM
- 0.7865 mL
- 3.9327 mL
- 7.8653 mL
- 10 mM
- 0.3933 mL
- 1.9663 mL
- 3.9327 mL
计算器摩尔计算器总药量计算器工作液计算器

技术信息

CAS号

22071-15-4

储存条件

粉末: -20°C 3 年

液体: -80°C 12 月

分子式

C16H14O3

运输

蓝冰

分子量

254.28

别名

RP-19583

溶解度

DMSO	50.0 mg/mL (196.6 mM)
Water	Insoluble
Ethanol	50.0 mg/mL (196.6 mM)

动物实验配方

靶点数据

生物活性

靶点 COX1

IC50:0.5μM COX2

IC50:2.33μM
描述Cyclooxygenase (COX) is the rate-limiting enzyme for the synthesis of prostaglandins. Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits both COX1 and COX2 in blood with the IC₅₀ values of 0.11 μM and 0.88 μM, respectively^[1]. Ketoprofen inhibited thromboxane B₂ (T_xB₂) production in freshly isolated platelets from human blood with an IC₅₀ value of 7.4 μM. The efficacy of ketoprofen in inhibiting LPS-induced T_xB₂ production in human mononuclear cells was determined with an IC₅₀ value of 7.7 μM^[2]. When HaCaT cells were irradiated with UVB (10 mJ/cm²), the activity of caspase-3 and the number of cells at the G2 phase were significant increased compared to cells without ketoprofen treatment. It was also shown that 100 μM Ketoprofen significantly provoked the accumulation of cyclin B1-cdc2-p21 complexes, as well as the amounts of Tyr15-phosphorylated cdc2 and p21 protein^[3].
作用机制Ketoprofen inhibits the activity of cyclooxygenase by conjugating with glucuronide and with coenzyme A^[4].
动物研究
剂量
Dog: 0.5 mg/kg - 2 mg/kg^[5] (s.c.); 0.25 mg/kg - 5 mg/kg^[5] (p.o.) Rat: 50 mg/kg^[6] (p.o.)

给药途径
s.c., p.o.

动物研究
剂量	Dog: 0.5 mg/kg - 2 mg/kg^[5] (s.c.); 0.25 mg/kg - 5 mg/kg^[5] (p.o.) Rat: 50 mg/kg^[6] (p.o.)
给药途径	s.c., p.o.

靶点	Description	IC50
COX1		IC50:0.5μM
COX2		IC50:2.33μM