HMGCR
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| FB09642 | Swertiamarine | 17388-39-5 | Swertiamarine is a naturally occuring secoiridoid glycoside which could inhibit HMG-CoA reductase activity. |
| FB10344 | SR-12813 | 126411-39-0 | SR-12813 is a pregnane X receptor (PXR) agonist and HMG-CoA reductase inhibitor with an IC50 of 850 nM. |
| FB09332 | Simvastatin Ammonium | 139893-43-9 | Simvastatin ammonium is an HMG-CoA reductase inhibitor. |
| FB09331 | Simvastatin | 79902-63-9 | Simvastatin a specific and a lovastatin similar HMG-CoA reductase inhibitor with Ki value of 0.1-0.2 nM, used to treat hypercholesterolemia. |
| FB09086 | Rosuvastatin | 287714-41-4 | Rosuvastatin is a synthetic and highly effective statin-class HMG-CoA reductase inhibitor with IC50 of 11 nM. |
| FB01669 | Rosuvastatin Calcium | 147098-20-2 | Rosuvastatin Calcium is a competitive and synthetic HMG-CoA reductase inhibitor with IC50 value of 11 nM. |
| FB01778 | Pravastatin Sodium | 81131-70-6 | Pravastatin Sodium is a competitive HMG-CoA reductase inhibitor with IC50 value of 5.6 μM. |
| FB09624 | Pravastatin | 81093-37-0 | Pravastatin is an HMG-CoA reductase inhibitor against sterol synthesis with IC50 of 5.6 μM. |
| FB03082 | Pitavastatin | 147511-69-1 | Pitavastatin is a potent HMG-CoA reductase inhibitor and inhibits cholesterol synthesis from acetic acid with an IC50 of 5.8 nM in a human liver cancer cell line (HepG2). |
| FB08435 | Pitavastatin Calcium | 147526-32-7 | Pitavastatin Calcium is a potent and competitive inhibitor of HMG-CoA reductase with Ki value of 1.7nM, which can block cholesterol synthesis. |
| FB07821 | Monacolin J | 79952-42-4 | Monacolin J is an inhibitor of cholesterol biosynthesis, and inhibits the activity of HMG-CoA reductase. |
| FB05933 | Mevastatin | 73573-88-3 | Mevastatin is the first discovered statin-class HMG-CoA reductase inhibitor used as a cholesterol-lowering agent isolated from Penicillium citinium. |
| FB05336 | Meglutol | 503-49-1 | Meglutol is an antilipemic agent which lowers cholesterol, triglycerides, serum beta-lipoproteins and phospholipids, and inhibits the activity of hydroxymethylglutarryl CoA reductases, which is the rate limiting enzyme in the biosynthesis of cholesterol. |
| FB03563 | Lovastatin | 75330-75-5 | Lovastatin is a HMG-CoA reductase used to treat high blood cholesterol and reduce the risk of cardiovascular disease, a naturally occuring fungal metabolite. |
| FB01884 | Fluvastatin Sodium | 93957-55-2 | Fluvastatin Sodium is a synthetic indole-heptanoic-acid-derived inhibitor of hepatic HMG-CoA reductase with IC50 of 8 nM. |
| FB00073 | Fluvastatin | 93957-54-1 | Fluvastatin inhibits HMG-CoA reductase activity with IC50 of 8 nM. |
| FB09713 | Clinofibrate | 30299-08-2 | Clinofibrate is a HMG-CoA reductase inhibitor with IC50 value of 470 μM which can reduce plasma cholesterol levels and shows antihyperlipidemic effects. |
| FB06611 | beta-Amyrin Acetate | 1616-93-9 | beta-Amyrin acetrate, a natural cannabinoid receptor isolated and purified from the herbs of Alstonia boone, shows significant HMG-CoA-reductase and sEH inhibitory activities. |
| FB17983 | Atorvastatin lactone | 125995-03-1 | Atorvastatin lactone is a prodrug form of atorvastatin. Atorvastatin is an orally active 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor. |
| FB00630 | Atorvastatin | 134523-00-5 | Atorvastatin is an inhibitor of HMG-CoA reductase used as a cholesterol-lowering medication that blocks the production of cholesterol. |
| FB00631 | Atorvastatin Hemicalcium | 134523-03-8 | Atorvastatin Hemicalcium is a potent HMG-CoA reductase inhibitor with IC50 value of 8 nM. |
| FB06765 | alpha-Asarone | 2883-98-9 | alpha-Asarone is a naturally occuring inhibitor of both HMG-CoA reductase (IC50 = 3 mM) and certain isoforms of the cytochrome P450 superfamily of enzymes (IC50 = 55.2 and 65.2 μg/ml for CYP2D6 and CYP3A4, respectively), with neuroprotective, anti-oxidative, anticonvulsive and cognitive enhancing action. |
| FB20306 | (3S,5R)-Fluvastatin sodium | 94061-81-1 | (3S,5R)-Fluvastatin sodium ((3S,5R)-XU 62-320) is the (3S,5R)-enantiomer of Fluvastatin. Fluvastatin is a first fully synthetic, competitive HMG-CoA reductase inhibitor with an IC50 of 8 nM. Fluvastatin protects vascular smooth muscle cells against oxidative stress through the Nrf2-dependent antioxidant pathway. |