Wnt
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| FB12491 | NSC 668036 | 144678-63-7 | NSC 668036 is a Wnt signaling inhibitor by binding the PDZ domain of the Dishevelled (Dvl) protein. It inhibits proliferation, migration and TGF-β-induced differentiation of fibroblasts in vitro. |
| FB12983 | Methyl Vanillate | 3943-74-6 | Methyl vanillate has ability to increase bone mass and activate wnt/β-catenin pathway. It can act as a potential lead anabolic agent for anti-osteoporosis drugs. |
| FB11970 | LF3 | 664969-54-4 | LF3 is an inhibitor of canonical wnt signaling pathway with IC50 of less than 2 μM. It can disrupt the interaction between β-catenin and TCF4. |
| FB10234 | KYA1797K | 1956356-56-1 | KYA1797K is a highly potent and selective Wnt/β-catenin inhibitor with IC50 of 0.75 µM (TOPflash assay). |
| FB02193 | KY 02111 | 1118807-13-8 | KY02111 can inhibit Wnt signaling and promote differentiation of hPSCs to cardiomyocytes. |
| FB12310 | JW 67 | 442644-28-2 | JW 67 is an inhibitor of canonical Wnt pathway signaling with IC50 of 1.17 μM. |
| FB03330 | IWP-2 | 686770-61-6 | IWP-2 is an inhibitor of porcn-mediated Wnt palmitoylation and secretion with IC50 of 27 nM. |
| FB12567 | IWP 4 | 686772-17-8 | IWP 4 is a potent inhibitor of Wnt/β-catenin signaling with IC50 of 25 nM. |
| FB07456 | iCRT-3 | 901751-47-1 | iCRT3 can inhibit both Wnt and β-catenin-responsive transcription. |
| FB05738 | iCRT 14 | 677331-12-3 | iCRT 14 is a potent inhibitor of β-catenin-responsive transcription (CRT) (IC50 = 40.3 nM in assays of Wnt pathway activity). Thought to directly influence the interaction between β-catenin and TCF4. Induces marked G0/G1 cell cycle arrest in HCT-116 and HT29 cell lines. |
| FB03719 | Gigantol | 67884-30-4 | Gigantol is a bibenzyl compound derived from several medicinal orchids. Giganto shows promising therapeutic potential against cancer cells. Gigantol is a novel inhibitor of the Wnt/β-catenin pathway. |
| FB03969 | CCT251545 | 1661839-45-7 | CCT251545 is an orally bioavailable and potent inhibitor of WNT signaling with IC50 value of 5 nM. |
| FB12525 | Cardionogen 1 | 577696-37-8 | Cardionogen 1 is an inhibitor of Wnt/β-catenin signaling. |
| FB01702 | BML-284 | 853220-52-7 | BML-284 is a Wnt signaling activator with EC50 value of 0.7 μM for inducing β-catenin and TCF-dependent transcriptional activity. |
| FB00359 | Adavivint | 1467093-03-3 | Adavivint is a potent and selective inhibitor of canonical Wnt signaling, with an EC50 of 19.5 nM via a high-throughput TCF/LEF-reporter assay in SW480 colon cancer cells. |
| FB18201 | MSAB | 173436-66-3 |