LPL Receptor
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| FB00722 | W146 | 909725-61-7 | W146 is a selective antagonist of sphingosine-1-phosphate receptor 1 (S1PR1) with an EC50 value of 398 nM. |
| FB06966 | TY-52156 | 934369-14-9 | TY-52156 is a potent S1P3 receptor antagonist in a competitive manner, and the Ki value is estimated to be 110 nM for S1P3 receptor. |
| FB02740 | TC-G 1006 | 1324003-64-6 | TC-G 1006 is a potent and orally active S1P1 agonist with EC50 of 18 nM, showing no activity on S1P3. |
| FB15209 | Sphingosine-1-phosphate | 26993-30-6 | Sphingosine 1-phosphate is the product of phosphorylation of sphingosine by sphingosine kinase and ligand for EDG-1 and EDG-3 and activator of GPR3, GPR6, and GPR12. |
| FB03023 | Siponimod | 1230487-00-9 | Siponimod is a selective S1P1 receptor modulator with EC50 of 0.4 nM, approved for treatment for secondary progressive multiple sclerosis. |
| FB05154 | SEW2871 | 256414-75-2 | SEW2871 is a potent and selective sphingosine-1-phosphate 1 (S1P1) receptor agonist. Activates S1P1 receptor with an EC50 of 13 nM, but does not activate S1P2, S1P3, S1P4 or S1P5 receptors at concentrations up to 10 μM. Cell-permeable and active in vivo. |
| FB10860 | RP001 HCl | 1781880-34-9 | RP001 is a sphingosine-1-phosphate receptor 1 agonist which inhibits tertiary lymphoid tissue reactivation and hypersensitivity in the lung. |
| FB07025 | Ponesimod | 854107-55-4 | Ponesimod is a selective S1P1 receptor modulator with EC50 of 5.7 nM, used in the reserch of treatment of multiple sclerosis (MS) and psoriasis. |
| FB00604 | Ozanimod | 1306760-87-1 | Ozanimod is an oral, once daily, selective sphingosine 1-phosphate 1 and 5 receptor modulator in development for autoimmune indications including relapsing multiple sclerosis (RMS) and ulcerative colitis (UC). |
| FB10279 | ONO-7300243 | 638132-34-0 | ONO-7300243 is a potent LPA1 (Lysophosphatidic Acid Receptor) antagonist with an IC50 of 160 nM. |
| FB04151 | KRP-203 HCl | 509088-69-1 | KRP-203 is a selective Sphingosine-1-phosphate receptor agonist that has been shown to reduce peripheral lymphocyte infiltration and to prolong survival in rat transplant models. |
| FB12602 | JTE 013 | 383150-41-2 | JTE 013 is a potent, selective S1P2 receptor antagonist with IC50 value of 17.6 nM. |
| FB11613 | GSK-2018682 | 1034688-30-6 | GSK-2018682 is a sphingosine 1 phosphate receptor (S1PR)-1 agonist potentially for the treatment of multiple sclerosis. GSK-2018682 induced acute, transient and non-symptomatic decreases in heart rate and blood pressure. |
| FB16921 | FTY720 (R)-Phosphate | 402616-23-3 | FTY720 (R)-Phosphate is the phosphate form of R-FTY720. Fingolimod is a sphingosine 1-phosphate (S1P) antagonist with IC50 of 0.033 nM in K562 and NK cells. |
| FB02115 | Fingolimod | 162359-55-9 | Fingolimod is a sphingosine 1-phosphate (S1P) antagonist with IC50 of 0.033 nM in K562 and NK cells. |
| FB05159 | Fingolimod HCl | 162359-56-0 | Fingolimod HCl is a S1P antagonist with IC50 of 0.033 nM. |
| FB05159 | Fingolimod HCl | 162359-56-0 | Fingolimod HCl is a S1P antagonist with IC50 of 0.033 nM. |
| FB08602 | CYM-5442 | 1094042-01-9 | CYM-5442 is a highly-selective S1P1 (Spingosine 1-Phosphate Receptor 1) agonist. CYM-5442 reduces the severity of acute GVHD by inhibiting macrophage recruitment. |
| FB16069 | CBP-307 | 2355293-36-4 | CBP-307 is a novel and selective second generation S1P1 (a G-protein coupled receptor -GPCR) modulator for the treatment of a range of autoimmune disorders, including multiple sclerosis, inflammatory bowel disease and psoriasis. CBP-307 exhibited excellent safety features and potent T cell modulation activity as well as optimal pharmacokinetics and pharmacodynamics profiles, demonstrating the best-in-class potential. CBP-307 is in phase I clinical trials by Suzhou Connect for the treatment of autoimmune diseases. |
| FB10096 | BMS-986020 | 1257213-50-5 | BMS-986020 is an LPA1 antagonist. |
| FB10294 | Amiselimod HCl | 942398-84-7 | Amiselimod HCl is a sphingosine 1-phosphate receptor-1 (S1P1) modulator, designed to reduce the bradycardia effects associated with fingolimod and other S1P receptor modulators. |
| FB02763 | AM095 | 1345614-59-6 | AM095 is a potent LPA1 receptor antagonist with IC50 values of 0.98 and 0.73 μM for recombinant human or mouse LPA1 respectively. |
| FB00540 | AM095 Free Acid | 1228690-36-5 | AM095 free acid is a potent LPA1 receptor antagonist with IC50 values of 0.98 and 0.73 μM for recombinant human or mouse LPA1 respectively. |
| FB11619 | AKP-11 | 1220973-37-4 | AKP-11 is a S1P1 agonist with immunomodulatory activities.AKP-11 (1.3mg/kg) attenuates EAE disease. |
| FB17227 | A-971432 | 1240308-45-5 | A-971432 is a selective S1PR5 (Sphingosine-1-Phosphate Receptor 5) agonist with EC50 values of 4.1 and 5.7 nM in cAMP and GTPγS assays, respectively. |