Topoisomerase
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| FB03999 | Voreloxin | 175414-77-4 | Voreloxin is a naphthyridine analogue with antineoplastic activity and an inhibitor of Topo II. |
| FB04001 | Voreloxin HCl | 175519-16-1 | Voreloxin HCl is a naphthyridine analogue with antineoplastic activity and an inhibitor of Topo II. |
| FB10891 | Voacamine | 3371-85-5 | Voacamine, isolated from the plant Tabernaemontana coronaria, is an antiprotozoal agent effective against a large array of trypanosomatid parasites including Indian strain of Leishmania donovani and Brazilian strains of Leishmania amazonensis and Trypanosoma cruzi by inhibiting the relaxation activity of topoisomerase IB. |
| FB11216 | Topoisomerase Inhibitor C14 | 1082340-21-3 | Topoisomerase inhibitor C14 is a 3-fluoro-6-methoxyquinoline derivatives and an inhibitor of bacterial DNA gyrase and topoisomerase IV. |
| FB10945 | Top-Tdp Tri Inhibitor C12 | 2092927-74-5 | Top-Tdp tri inhibitor C12 is one of the first triple inhibitors of human topoisomerase 1, tyrosyl–DNA phohosphodiesterase 1 (Tdp1), and tyrosyl–DNA phosphodiesterase 2 (Tdp2). |
| FB03996 | TAS-103 | 174634-08-3 | TAS-103 is a dual inhibitor of topoisomerase-I (topo-I) and topoisomerase-II (topoII). |
| FB00655 | TAS-103 2HCl | 174634-09-4 | TAS-103 2HCl is a dual inhibitor of topoisomerase-I (topo-I) and topoisomerase-II (topoII). |
| FB00648 | SW044248 | 522650-83-5 | SW044248 is a noncanonical Top1 inhibitor with a pattern of selective toxicity for NSCLC cells. |
| FB10613 | SN-38 | 86639-52-3 | SN-38 is an active metabolite of CPT-11 that inhibits DNA topoisomerase I, DNA synthesis and causes frequent DNA single-strand breaks. |
| FB11051 | Sabarubicin | 211100-13-9 | Sabarubicin is a Top II inhibitor with anticancer activity. |
| FB07157 | Pirarubicin HCl | 95343-20-7 | Pirarubicin HCl is an analogue of the anthracycline anti-neoplastic doxorubicin, which is an inhibitor of Topo II. |
| FB03346 | Pefloxacin Mesylate Dihydrate | 149676-40-4 | Pefloxacin mesylate, antibacterial agent, can prevent bacterial DNA replication via inhibiting DNA gyrase or topoisomerse. |
| FB16488 | NSC745887 | 54490-26-5 | NSC745887 can effectively inhibit the proliferation of various cancers by trapping DNA-topoisomerase cleavage. NSC745887 reduced the cell survival rate and increased the sub-G1 population in dose- and time-dependent manners in GBM cells. Moreover, NSC745887 increased expression of γH2AX and caused DNA fragmentation leading to DNA damage.NSC745887 caused apoptosis by the caspase-8/9-caspase-3-poly(ADP-ribose) polymerase cascade. |
| FB10869 | NISC-6 | 2097636-49-0 | NISC-6 is a napthalamide-isoselenocyanate compound which acts as a dual Topoisomerase-IIα and Akt pathway inhibitor. |
| FB17796 | Nalidixic acid sodium salt | 3374-05-8 | Nalidixic acid sodium salt, a quinolone antibiotic, is effective against both gram-positive and gram-negative bacteria. Nalidixic acid acts in a bacteriostatic manner in lower concentrations and is bactericidal in higher concentrations. Nalidixic acid inhibits a subunit of DNA gyrase and topoisomerase IV and reversibly blocks DNA replication in susceptible bacteria. |
| FB03450 | Nadifloxacin | 124858-35-1 | Nadifloxacin is a fluoroquinolone broad-spectrum antibacterial, working by inhibiting the enzyme DNA gyrase and thus inhibiting the bacterial multiplication. |
| FB10548 | Moxifloxacin HCl | 186826-86-8 | Moxifloxacin HCl is a fluoroquinolone antibiotic agent. |
| FB12886 | Levofloxacin HCl | 177325-13-2 | Levofloxacin HCl, a fluoroquinolone antibiotic, is an inhibitor of DNA gyrase and topoisomerase IV. |
| FB07674 | Irinotecan | 97682-44-5 | Irinotecan is a camptothecin analog prevents DNA from unwinding by inhibition of topoisomerase 1. |
| FB07698 | Irinotecan HCl | 100286-90-6 | Irinotecan HCl is an inhibitor of topoisomerase 1 that prevents DNA from unwinding. |
| FB02799 | INNO-206 | 1361644-26-9 | INNO-206 is the 6-maleimidocaproyl hydrazone derivative prodrug of the anthracycline antibiotic doxorubicin (DOXO-EMCH) with antineoplastic activity. |
| FB12027 | Indotecan | 915303-09-2 | Indotecan is a potent topoisomerase 1(Top1) inhibitor with IC50 values of 300, 1200, 560 nM for P388, HCT116, MCF-7 cell lines, respectively. |
| FB06650 | Idarubicin | 58957-92-9 | Idarubicin is a semisynthetic 4-demethoxy analogue of the antineoplastic anthracycline antibiotic daunorubicin. |
| FB08592 | Idarubicin HCl | 57852-57-0 | Idarubicin HCl is a HCl salt form of idarubicin which is an anthracycline antibiotic and a DNA topoisomerase II (topo II) inhibitor for MCF-7 cells with IC50 of 3.3 ng/mL in a cell-free assay. |
| FB07787 | Gepotidacin | 1075236-89-3 | Gepotidacin is a first in class triazaacenaphthylene antibiotic that inhibits bacterial type II DNA replication by inhibiting the activity of bacterial topoisomerase and has in vitro activity against susceptible and drug-resistant pathogens. |
| FB06178 | Genz-644282 | 529488-28-6 | Genz-644282 is a non-camptothecin inhibitor of topoisomerase I with potential antineoplastic activity (IC50=1.2 nM). |
| FB11205 | F14512 | 866874-63-7 | F14512 is a DNA topoisomerase II inhibitor potentially for the treatment of acute myeloid leukemia. |
| FB03976 | Exatecan Mesylate | 169869-90-3 | Exatecan mesylate is a totally synthetic analogue of the topoisomerase I-inhibitor camptothecin, which was synthesised to impart increased aqueous solubility, greater tumour efficacy, and less toxicity than camptothecin itself. |
| FB08428 | Exatecan | 171335-80-1 | Exatecan is a totally synthetic analogue of the topoisomerase I-inhibitor camptothecin, which was synthesised to impart increased aqueous solubility, greater tumour efficacy, and less toxicity than camptothecin itself. |
| FB02434 | Etoposide | 33419-42-0 | Etoposide inhibits DNA synthesis by inhibiting topoisomerase II (IC50 = 60.3 μM). |
| FB08260 | Epirubicin HCl | 56390-09-1 | Epirubicin HCl, a L-arabino derivative of doxorubicin, can inhibit topoisomerase and used as antineoplastic agent. |
| FB10052 | Ellipticine HCl | 5081-48-1 | Ellipticine HCl is a potent antineoplastic agent and inhibits DNA topoisomerase II activities. |
| FB00905 | Doxorubicin HCl | 25316-40-9 | Doxorubicin HCl is an antibiotic agent that inhibits DNA topoisomerase II and induces DNA damage and apoptosis in tumor cells. |
| FB03275 | DOXO-EMCH | 151038-96-9 | DOXO-EMCH is a 6-maleimidocaproyl hydrazone derivative of Doxorubicin, is an albumin binding prodrug. |
| FB07032 | Daunorubicin HCl | 23541-50-6 | Daunorubicin HCl can inhibit both DNA synthesis (Ki = 0.02 μM) and RNA synthesis. |
| FB06137 | Daun02 | 290304-24-4 | Daun02 is converted by β-galactosidase to Daunorubicin, which is a topoisomerase inhibitor, and alsois a daunorubicin b-galactoside prodrug for use in conjunction. |
| FB09776 | Coralyne | 6872-73-7 | Coralyne is a cytotoxic agent trageting topoisoerase I, used in combinational chemotherapy to improve the effectiveness in combating proliferation of cancer cells. |
| FB08926 | Ciprofloxacin HCl H2O | 86393-32-0 | Ciprofloxacin HCl is an antibiotic agent and used to treat bacterial infections. |
| FB19554 | Chrysomycin B | 83852-56-6 | Chrysomycin B is an antibiotic isolated from a strain of Streptomyces. It inhibits topoisomerase II and causes DNA damage in A549 cell line. |
| FB08157 | Campathecin | 7689-03-4 | Camptothecin is a potent DNA enzyme topoisomerase I (topo I) inhibitor with an IC50 and IC70 of 50 nM and 0.225 μM for breast cancer cell line MDA-MB-231. |
| FB11748 | BNP 1350 | 203923-89-1 | BNP 1350 is a topoisomerase I inhibitor, with potent anti-cancer activity. |
| FB06171 | Amsacrine | 51264-14-3 | Amsacrine can intercalate into the DNA of tumor cells with antineoplastic activity. |
| FB02258 | Amrubicin HCl | 110311-30-3 | Amrubicin HCl is a topoisomerase II inhibitor used in the treatment of lung cancer. |
| FB03871 | Alternariol | 641-38-3 | Alternariol is a mycotoxin, topoisomerase I and II inhibitor and potential ER agonist found in Alternaria. |
| FB11136 | AEZS-108 | 139570-93-7 | AEZS-108 is a peptide agonist of the gonadotropin releasing hormone-1 receptor (GnRH-1R). |
| FB07330 | Aclarubicin | 57576-44-0 | Aclarubicin is an oligosaccharide anthracycline antineoplastic antibiotic isolated from the bacterium Streptomyces galilaeus. |
| FB11135 | Aclarubicin HCl | 75443-99-1 | Aclarubicin HCl is the HCl salt of aclarubicin, an oligosaccharide anthracycline antineoplastic antibiotic isolated from the bacterium Streptomyces galilaeus. |
| FB16109 | 1,4-Naphthoquinone | 130-15-4 | A choleretic. |
| FB05893 | 3-O-trans-p-Coumaroyltormentic Acid | 121064-78-6 | 3-O-trans-p-Coumaroyltormentic acid, a natural product isolated and purified from the leaves of Eriobotrya japonica calli, induces apoptotic cell death in human leukemia (HL60) via mainly mitochondrial pathway by, at least in part, Topo I inhibition, and may be promising lead compound for developing an effective drug for treatment of leukemia. |
| FB10669 | 10-Hydroxycamptothecin | 64439-81-2 | (±)-10-Hydroxycamptothecin is an inhibitor of topoisomerase I and can affect phosphorylation of histone H1 and H3 with anticancer activity. It can be isolated from camptotheca acuminate. |