GABA Receptor
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| FB16903 | ZK 93426 HCl | 1216792-30-1 | ZK 93426 hydrochloride is selective and competitive benzodiazepine receptor antagonist with IC50 values of 0.4 and 0.7 nM for inhibition of [3H]-flunitrazepam binding to rat cerebellum and hippocampus respectively. |
| FB16900 | ZK 93423 HCl | 1216574-52-5 | ZK 93423 hydrochloride is agonist of benzodiazepine receptor with IC50 of 1 nM. It is non-selective between α1-, α2-, α3- and α5-subunit containing GABAA receptors. |
| FB02827 | Vigabatrin HCl | 1391054-02-6 | Vigabatrin HCl is a structural analog of the inhibitory neurotransmitter γ-aminobutyric acid (GABA) that irreversibly inhibits the catabolism of GABA by GABA transaminase. |
| FB10339 | U93631 | 152273-12-6 | U93631 is a ligand of GABAA receptor ligand (IC50 = 100 nM) which can induce a rapid decay of GABA-induced chloride currents. |
| FB02471 | Thymol | 89-83-8 | Thymol, a natural product isolated and purified from the herbs of Thymus serpyllum L., is a positive allosteric modulator of human GABAA receptors and a homo-oligomeric GABA receptor from Drosophila melanogaster. |
| FB11698 | SX-3228 | 156364-04-4 | SX-3228 is a selective benzodiazepine1 (BZ1) receptor agonist with an IC50 of 17 nM. |
| FB11526 | SSD114 HCl | N/A | SSD114 is a GABAB positive allosteric modulator. SSD114 potentiated GABA-stimulated [35S]GTPγS binding to native GABAB receptors, whereas it had no effect when used alone. SSD114, a molecule with a different chemical structure compared to known GABAB PAMs, is a novel GABAB PAM with potential usefulness in the GABAB-receptor research field. |
| FB09253 | Securinine | 5610-40-2 | Securinine, a natural product isolated and purified from the leaves and twigs of Securinega suffruticosa with antifungal activity, induces apoptosis in human leukemia HL-60 cells, is a promising monocytic differentiation inducing agent for Acute Myeloid Leukemia (AML). |
| FB09204 | Sarmazenil | 78771-13-8 | Sarmazenil is a benzodiazepine receptor antagonist. |
| FB03717 | Sanggenon D | 81422-93-7 | Sanggenon D, a natural product isolated and purified from the root bark of Morus alba L. |
| FB15230 | SAGE-217 | 1632051-40-1 | SAGE-217 is an agonist of GABAA receptor with EC50s of 296 nM and 163 nM for α1β2γ2 and α4β3δ respectively. |
| FB16909 | RuBi-GABA | 1028141-88-9 | RuBi-GABA can be excited by visible wavelengths with greater tissue penetration, less phototoxicity, faster photorelease kinetics and better spatial resolution UV light-sensitive caged compounds. |
| FB02139 | RO 4938581 | 883093-10-5 | RO 4938581 is a potent and selective GABAA α5 inverse agonist, with a Ki of 4.6 nM for GABAA α5β3γ2a, and shows a lower affinity at α1β3γ2a, α2β3γ2a, α3β3γ2a (Ki, 174, 185, 80 nM, respectively); RO 4938581 is used in the research of cognitive dysfunction. |
| FB01526 | Ro 48-6791 | 172407-17-9 | Ro 48-6791 is a GABA receptor agonist potentially for the use of anesthesia. |
| FB07522 | Ro 15-3890 | 84378-44-9 | Ro 15-3890 is an antagonist of benzodiazepine receptor. It is a main metabolite of Ro 15-1788 (flumazenil). |
| FB01912 | Remimazolam Benzenesulfonate | 1001415-66-2 | Remimazolam benzenesulfonate is a GABA agonist that acts on GABA receptor, specifically GABA-alpha. |
| FB17230 | Pivagabine | 69542-93-4 | Pivagabine has a highly significant therapeutic potential in clinical conditions characterized by manifestations of psychological distress due to an inadequate management of stressful events. |
| FB00763 | Phenylpiracetam | 77472-70-9 | Phenylpiracetam is a phenylated derivative of the nootropic drug piracetam with anti-amnesic and antidepressant effects that can be used as a stimulant nootropic drug. |
| FB12897 | Phenibut | 1078-21-3 | Phenibut, a GABA analogue, is a central nervous system depressant with anxiolytic and sedative effects. |
| FB07453 | Oxiracetam(Random Configuration) | 62613-82-5 | Oxiracetam is a derivative of gamma-aminobutyric acid (GABA) and used as a nootropic drug to improve memory and learning. |
| FB16780 | ONO-8590580 | 1802661-73-9 | ONO-8590580 is a GABAAα5 negative allosteric modulator which enhances long-term potentiation and improves cognitive deficits in preclinical models. |
| FB13145 | MRX-1024 | 348-67-4 | MRX-1024 can inhibit the activation of GABAA receptor and exhibit relieving effect on hearing loss. It can used as a chemoprotective agent. |
| FB00663 | MK 0343 | 233275-76-8 | MK 0343 is a selective partial agonist of GABAAα3, α1, α5 and α2 with Ki values of 0.21 nM-0.40 nM. It displays anxiolytic activity in rodent and primate models. |
| FB16896 | Midazolam HCl | 59467-96-8 | Midazolam hydrochloride is a sedative/hypnotic agent which can act at the GABAA receptor benzodiazepine modulatory site. |
| FB06942 | Lorediplon | 917393-39-6 | Lorediplon, non-benzodiazepine hypnotic drug, acts as a modulator of GABAA receptor with the effect of promoting sleep. |
| FB02103 | Loreclezole HCl | 2227372-56-5 | Loreclezole HCl is a subtype-selective GABAA receptor modulator. Acts as a positive allosteric modulator of β2 or β3-subunit containing receptors. |
| FB02720 | L-655,708 | 130477-52-0 | L-655708 is a potent α5 subunit-selective GABAA receptor inverse agonist (Ki = 0.45 nM). |
| FB16583 | Isonipecotic acid | 498-94-2 | Isonipecotic acid is a specific GABAA receptor agonist. |
| FB16620 | Ganaxolone | 38398-32-2 | Ganaxolone, also known as CCD 1042 and C1042, is a CNS-selective GABAA modulator that acts on well-characterized targets in the brain known to have anxiolytic and anticonvulsant effects. Ganaxolone protects against seizures in diverse animal models, including the pentylenetetrazol, 6 Hz and amygdala kindling models. Ganaxolone is a positive allosteric modulator of the action of the GABAA receptor and, unlike benzodiazepines, there does not appear to be tolerance to the anticonvulsant effects of ganaxolone. |
| FB09906 | Flutoprazepam | 25967-29-7 | Flutoprazepam is a drug which is a benzodiazepine. |
| FB18050 | FG-7142 | 78538-74-6 | FG 7142 (ZK 39106; LSU-65), a non-selectively benzodiazepine inverse agonist, has high affinity for the α1 subunit-containing GABAA receptor (Ki=91 nM). FG 7142 (ZK 39106; LSU-65) also modulates GABA-induced chloride flux at GABAA receptors expressing the α1 subunit (EC50= 137 nM). FG 7142 (ZK 39106; LSU-65) can increase tyrosine hydroxylation and cause upregulation of β-adrenoceptors in mouse cerebral cortex . |
| FB10816 | EVT-201 | 308239-86-3 | EVT-201 is a benzodiazepine derivative drug and partial positive allosteric modulator of the benzodiazepine site of the GABA receptor. |
| FB06180 | Etomidate HCl | 53188-20-8 | Etomidate HCl is a GABAA receptors agonist, which is a short acting intravenous anaesthetic agent used for the induction of general anaesthesia. |
| FB06195 | Etifoxine HCl | 56776-32-0 | Etifoxine HCl is a potentiator of β2 or β3 subunit-containing GABAA receptor that promotes axonal regeneration. It shows anxiolytic activity with no effects. |
| FB16897 | CL 218872 | 66548-69-4 | CL 218872 is an agonist of benzodiazepine which displaying selectivity for α1 subunit-containing GABAA receptors with Ki values are 130, 1820, 1530, > 10000, 490 and > 10000 nM for α1, α2, α3, α4, α5 and α6-subunit containing receptors respectively. |
| FB02580 | CGS-9896 | 77779-36-3 | CGS-9896 is an anxiolytic drug used in scientific research. |
| FB16904 | CGS 20625 | 111205-55-1 | CGS 20625 is selective and partial agonist for the benzodiazepine binding site of the GABAA receptor. It has anxiolytic activity. |
| FB11574 | CGP52432 | 139667-74-6 | CGP52432 is an antagonist of GABAB receptor with an IC50 of 85 nM. |
| FB10884 | Broflanilide | 1207727-04-5 | Broflanilide is a potential insecticide and metabolized to desmethyl-broflanilide, which is a potent antagonist at the insect resistant-to-dieldrin (RDL) GABA receptor, and inhibits S. litura RDL GABAR, with an IC50 value of 1.3 nM. |
| FB17201 | Brexanolone | 516-54-1 | Brexanolone, a GABAA receptor positive allosteric modulator, is used for treating neurological diseases such as post-partum depression, epilepsy, Alzheimer disease, and so on. |
| FB07275 | Bemegride | 64-65-3 | Bemegride can stimulate central nervous system and release barbiturate poisoning. |
| FB10342 | Basmisanil | 1159600-41-5 | Basmisanil is a selective modulator of GABAAα5 with negative allosteric regulation. |
| FB16468 | AZD7325 | 942437-37-8 | AZD-7325 is a GABA-Aα2,3 selective receptor modulator. |
| FB07136 | 3β-Hydroxypregnan-20-one | 4406-37-5 | Allopregnanolone, a GABAA receptor positive allosteric modulator, is used for treating neurological diseases such as post-partum depression, epilepsy, Alzheimer disease, and so on. |
| FB12920 | 6-Methyl-2-phenyl-4H-chromen-4-one | 29976-75-8 | 6-Methylflavone is an activator of α1β2γ2L and α1β2 GABAA receptors. |
| FB12881 | 6-Hydroxyflavone | 6665-83-4 | 6-Hydroxyflavone is a naturally occurring flavone, with anti-inflammatory activity. 6-Hydroxyflavone exhibits inhibitory effect towards bovine hemoglobin (BHb) glycation. 6-Hydroxyflavone can activate AKT, ERK 1/2, and JNK signaling pathways to effectively promote osteoblastic differentiation. 6-Hydroxyflavone inhibits the LPS-induced NO production[1] [2]. |
| FB12880 | 5-methoxyflavone | 42079-78-7 | 5-Methoxyflavone, belonged to Flavonoid family, is a DNA polymerase-beta inhibitor and neuroprotective agent against beta-amyloid toxicity. possess central nervous system (CNS) depressant effect mediated through the ionotropic GABAA receptors. |
| FB16150 | 3,4,5-Trimethoxycinnamic acid | 90-50-6 | 3,4,5-Trimethoxycinnamic acid (TMCA) is one of the constituents of Polygalae Radix and may exert anti-seizure activity by acting at the GABAA/BZ receptor complex. |
| FB13126 | L-Glutamic Acid | 56-86-0 | (S)-Glutamic acid acts as an excitatory neurotransmitter in the central nervous system. |
| FB18178 | GABAA receptor agent 1 | 1571-87-5 |