β-catenin
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| FB18060 | β-catenin-IN-2 | 1458664-10-2 | β-catenin-IN-2 is a potent β-catenin inhibitor that can be used for the study of colorectal cancer. |
| FB02269 | WAY-262611 | 1123231-07-1 | WAY-262611 is an agonist of β-Catenin and can increase bone formation rate with EC50 of 0.63 μM. |
| FB10232 | SKL2001 | 909089-13-0 | SKL2001 is Wnt/β-catenin pathway agonist which interferes in the interaction of Axin/β-catenin. |
| FB11070 | PP2A-β-Catenin Inhibitor CS-11 | N/A | PP2A-β-Catenin inhibitor CS-11 a small molecule inhibitor of PP2A-β-catenin signaling that limits both in vivo tumor growth and metastasis. |
| FB11263 | KY1220 | 292168-79-7 | KY1220 inhibits Wnt/β-catenin pathway with IC50 of 2.1 μM in HEK293 cells and it can destabilize both β-catenin and Ras. |
| FB02489 | ICG-001 | 868774-16-7 | ICG-001 is an inhibitor of β-catenin/cyclic AMP responsive element binding protein binding protein (CBP)-mediated transcription with IC50 of 3 µM. |
| FB11975 | C-82 | 1422253-37-9 | C-82 is an active metabolite of PRI-724 which selectively inhibits the CBP/β-catenin interaction. |
| FB05469 | Boehmenan | 57296-22-7 | Boehmenan, a natural product isolated and purified from the herbs of Euphorbia hirta Linn., exhibits cytotoxicity against both Wnt-dependent (HCT116) and Wnt-independent (RKO) cells, and decreases the expression of full, cytosolic and nuclear β-catenin along with c-myc in STF/293 cells, suggesting that boehmenan may have inhibited the Wnt signal by decreasing β-catenin levels. |
| FB11069 | BC2059 | 1227637-23-1 | beta-Catenin inhibitor BC2059 is efficacious as monotherapy or in combination with proteasome inhibitor bortezomib in multiple myeloma. |
| FB17709 | aStAx 35 | 1418863-14-5 | aStAx 35 is a hydrocarbon-stapled peptide that directly targets β-catenin with kd value of 13nM and interferes with its ability to serve as a transcriptional coactivator for T-cell factor (TCF) proteins. |