CAS:13710-19-5Tolfenamic Acid

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Tolfenamic acid is a selective COX2 inhibitor with IC50 of 13.49 μM, it's a non-steroidal anti-inflammatory drugs (NSAIDs).

规格	价格	促销价格	库存

18817579266

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18817579266

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实验数据

技术信息

CAS号

13710-19-5

储存条件

分子式

C14H12ClNO2

运输

蓝冰

分子量

261.70

别名

溶解度

动物实验配方

生物活性

描述Tolfenamic Acid is a nonsteroidal antiinflammatory agent, selectively inhibits COX-2, with an IC50 of 13.49 μM (3.53 μg/mL) in LPS-treated (COX-2) canine DH82 monocyte/macrophage cells, but shows no effect on COX-1^[3]. Tolfenamic Acid also acts as a potent Sp protein inhibitor. Tolfenamic acid (TA) inhibits cancer cell proliferation and tumor growth through the degradation of Sp1, Sp3, and Sp4. Tolfenamic Acid (50 mg/kg 3 times/wk, p.o.) inhibits tumor formation and tumor incidence in N-nitrosomethylbenzylamine (NMBA)-induced esophageal tumor model. Tolfenamic Acid also causes decreases in tumor multiplicity and tumor volume in rats treated with NMBA^[4]. Tolfenamic Acid (50 μM) significantly affects gene expression in L3.6pl cells, and downregulates CENPF, KIF20A, LMNB1, MYB, SKP2, CCNE2, and DDIT3^[5]. TA has shown excellent in vitro antibacterial activity against certain ATCC strains of bacteria when complexed with bismuth(III) ^[6].