SPHK
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| FB11289 | SKI-178 | 1259484-97-3 | SKI-178 is an in vivo active non-lipid sphingosine kinase 1 (SphK1) inhibitor (IC50 = 0.1-1.8 μM), which induces CDK1-dependent apoptosis in human acute myeloid leukemia cell lines. |
| FB07501 | SKI II | 312636-16-1 | SKI II is an inhibitor of non ATP-competitive sphingosine kinase (SphK) with IC50 of 0.5 μM. |
| FB03184 | PF-543 | 1415562-82-1 | PF-543 is a cell-permeant inhibitor of SphK1 with a Ki of 3.6 nM, PF-543 is sphingosine-competitive and is more than 100-fold selective for SphK1 over the SphK2 isoform. |
| FB12625 | PF 543 HCl | 1706522-79-3 | PF-543 HCl is a cell-permeant inhibitor of SphK1 with a Ki of 3.6 nM, PF-543 is sphingosine-competitive and is more than 100-fold selective for SphK1 over the SphK2 isoform. |
| FB03185 | PF-543 Citrate | 1415562-83-2 | PF-543 citrate is a cell-permeant inhibitor of SphK1 with a K (i) of 3.6 nM, PF-543 is sphingosine-competitive and is more than 100-fold selective for SphK1 over the SphK2 isoform. |
| FB04092 | MP-A08 | 219832-49-2 | MP-A08 is a highly selective ATP competitive SK inhibitor that targets both SK1 and SK2 with Kivalues of 6.9 ± 0.8 μM and 27 ± 3 μM, respectively. |
| FB02724 | K145 | 1309444-75-4 | K145 is a selective SphK2 inhibitor with an IC50 of 4.30±0.06 μM , while no inhibition of SphK1 at concentrations up to 10 μM. |
| FB03247 | K145 HCl | 1449240-68-9 | K145 HCl is a selective SphK2 inhibitor with an IC50 of 4.30±0.06 μM , while no inhibition of SphK1 at concentrations up to 10 μM. |
| FB15610 | Defensamide | 1104874-94-3 | Defensamide is an activator of SPHK1, and significantly stimulates CAMP mRNA and protein production in KC. |
| FB01081 | ABC294640 | 915385-81-8 | ABC294640 markedly alters the ratio of ceramide/S1P consistent with inhibition of SK activity in MDA-MB-231 cells. |