DHFR
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| FB01654 | Trimethoprim | 738-70-5 | Trimethoprim is a synthetic antibiotic that inhibits dihydrofolate reductase (DHFR) which is necessary for the synthesis of purines, amino acids, and thymidylic acid, with prominent selectivity for bacterial DHFR over mammalian DHFR (IC50s = 5 and 30,000 nM, respectively). Trimethoprim is used mainly in the prophylaxis and treatment of urinary tract infections. |
| FB06434 | Pyrimethamine | 58-14-0 | Pyrimethamine inhibits multidrug and toxin extrusion (MATE) transporter potently, it also inhibits dihydrofolate reductase (DHFR), used for protozoal infections and interferes with tetrahydrofolic acid synthesis from folic acid. |
| FB00185 | Pralatrexate | 146464-95-1 | Pralatrexate is an antifolate, and structurally a folate analog. Its IC50 is < 300 nM in some cell lines. |
| FB08042 | Pemetrexed | 137281-23-3 | Pemetrexed is an antifolate and antimetabolite for TS(thymidylate synthase), DHFR(dihydrofolate reductase) and GARFT(glycinamide ribonucleotide formyltransferase) with Ki of 1.3 nM, 7.2 nM and 65 nM, respectively. |
| FB04589 | Pemetrexed Disodium | 150399-23-8 | Pemetrexed Disodium is an antifolate and antimetabolite for TS, DHFR and GARFT with Ki of 1.3 nM, 7.2 nM and 65 nM, respectively. |
| FB05923 | Pemetrexed Disodium Hydrate | 357166-30-4 | Pemetrexed disodium is an antifolate and antimetabolite for TS, DHFR and GARFT with Ki of 1.3 nM, 7.2 nM and 65 nM, respectively. |
| FB03452 | Pemetrexed Disodium Heptahydrate | 357166-29-1 | Pemetrexed disodium is a guanine-derived antineoplastic agent that functions as a nucleic acid synthesis inhibitor through its binding to, and inhibition of, thymidylate synthase. |
| FB10596 | Methotrexate | 59-05-2 | Methotrexate, an antifolate compound, is a nonspecific inhibitor of the dihydrofolate reductase(DHFR) of bacteria and cancerous cells as well as normal cells. It forms an inactive ternary complex with DHFR and NADPH and can interfere with the growth of certain cells of the body, especially cells that reproduce quickly, such as cancer cells, bone marrow cells, and skin cells. |
| FB12047 | LY309887 | 127228-54-0 | LY309887 is a potent inhibitor of glycinamide ribonucleotide formyltransferase (GARFT), with a Ki of 6.5 nM, and has antitumor activity. |
| FB12045 | LY 222306 | 154446-98-7 | LY 222306 is a glycinamide ribonucleotide formyltransferase (GARFT) inhibitor with a Ki of 0.77 nM. |
| FB00484 | Levomefolic Acid | 31690-09-2 | Levomefolic acid is the natural, active form of folic acid used at the cellular level for DNA reproduction, the cysteine cycle and the regulation of homocysteine among other functions. |
| FB10539 | Levomefolate Calcium | 151533-22-1 | Levomefolate Calcium is an artificial form of folate. |
| FB10518 | Calcium Folinate | 1492-18-8 | Leucovorin calcium is a reduced form of folic acid. |
| FB04159 | Folinic Acid | 58-05-9 | Folinic acid is an adjuvant used in cancer chemotherapy involving the drug methotrexate. |
| FB01906 | Folinic Acid Calcium Pentahydrate | 6035-45-6 | Folinic acid is a reduced folic acid, which is used in combination with other chemotherapy drugs. |
| FB00401 | Diaveridine | 5355-16-8 | Diaveridine is a dihydrofolate reductase (DHFR) inhibitor with Ki of 11.5 nM, also an antibacterial agent. |
| FB12778 | Diaveridine HCl | 2507-23-5 | Diaveridine HCl is a coccidiostat and inhibits dihydrofolate reductase. It can prevente folic acid synthesis in species of Pneumocystis. Diaveridine also has genotoxicity. |
| FB12883 | Cycloguanil HCl | 152-53-4 | Cycloguanil HCl is HCl form of cycloguanil which is a metabolite of proguanil and a dihydrofolate reductase inhibitor. |
| FB10530 | Calcium N5-methyltetrahydrofolate | 26560-38-3 | Calcium N5-methyltetrahydrofolate is the calcium salt of levomefolic acid, which has been proposed for treatment of cardiovascular disease and advanced cancers such as breast and colorectal cancers. |
| FB10463 | Calcium Levofolinate | 80433-71-2 | Calcium levofolinate is the calcium salt of levoleucovorin, which is the enantiomerically active form of folinic acid. |
| FB11954 | AG 2037 | 446022-33-9 | AG 2037 (Pelitrexol) is an inhibitor of glycinamide ribonucleotide formyltransferase (GARFT). |
| FB17225 | 1-(4-Chlorophenyl)biguanide HCl | 4022-81-5 | 1-(4-Chlorophenyl)biguanide is a guanide derivative that can inhibit dihydrofolate reductase (DHFR). |