Flavonoids
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| FB10612 | Tricin | 520-32-1 | Tricin, a natural product isolated and purified from the herb of Avena sativa, is evaluated as a type of tyrosinase inhibitor, exerts anti-inflammatory effect via a mechanism involving the TLR4/NF-κB/STAT signaling cascade, may be beneficial in HSC-targeting therapeutic or chemopreventive applications for hepatic fibrosis, and is with potential anti-HCMV activity and that CXCL11 is one of the chemokines involved in HCMV replication. |
| FB10612 | Tricin | 520-32-1 | Tricin, a natural product isolated and purified from the herb of Avena sativa, is evaluated as a type of tyrosinase inhibitor, exerts anti-inflammatory effect via a mechanism involving the TLR4/NF-κB/STAT signaling cascade, may be beneficial in HSC-targeting therapeutic or chemopreventive applications for hepatic fibrosis, and is with potential anti-HCMV activity and that CXCL11 is one of the chemokines involved in HCMV replication. |
| FB00224 | Tiliroside | 20316-62-5 | Tiliroside, a natural product isolated and purified from the herbs of Agrimonia pilosa Ledeb. |
| FB04341 | Tephrosin | 76-80-2 | Tephrosin, a natural product isolated and purified from the herbs of Derris robusta, may be valuable for augmenting the therapeutic efficacy of 2-Deoxy-D-glucose(DG), has potent antitumor activity by inducing autophagy pathway, internalization and degradation of inactivated EGFR and ErbB2, and exerts antitumor effects by inducing internalization and degradation of inactivated EGFR and ErbB2 in human colon cancer cells. |
| FB05425 | Sanggenol A | 174423-30-4 | Sanggenol A, a natural product isolated and purified from the root bark of Morus alba L., shows protective effect on glutamate-induced cell death in HT22 cells, with EC50 values of 34.03 ± 7.71 uM, and inhibits influenza A viral and pneumococcal neuraminidase (NA), it also disrupts the synergism between influenza A virus and pneumococcal NA in vitro, hence functioning as dual-acting anti-infectives. |
| FB05115 | Salvigenin | 19103-54-9 | Salvigenin, a natural product isolated and purified from the roots of Salvia japonica, with antitumor and immunomodulatory effects, reduces tumor cell growth in RIN cell line, and also inhibits the growth of tumor tissue in vivo. |
| FB11454 | Robustaflavone | 49620-13-5 | Robustaflavone is a naturally occurring biflavanoid isolated from rhus succedanea, it can be act as an inhibitor of hepatitis B virus replication. |
| FB02412 | Rhoifolin | 17306-46-6 | Rhoifolin, a natural product isolated and purified from the leaves of Turpinia arguya Seem, hows monolithic proliferation inhibitory activities against Hela, A549 and MCF-7 cell lines, and may be beneficial for diabetic complications through their enhanced adiponectin secretion, tyrosine phosphorylation of insulin receptor-β and GLUT4. It was found to efficiently block the enzymatic activity of SARS-CoV 3CLpro. |
| FB04142 | Quercitrin | 522-12-3 | Quercitrin, a natural product isolated and purified from the herb of Apocynum venetum L. |
| FB11473 | Quercetin-3-O-beta-D-glucose-7-O-beta-D-gentiobioside | 60778-02-1 | Quercetin-3-O-beta-D-glucose-7-O-beta-D-gentiobioside is a natural product from desurainia sophia. |
| FB08575 | Procyanidin A2 | 41743-41-3 | Procyanidin A2, a natural product isolated and purified from the rhizomes of Belamcanda chinensis (L.) DC., blocks apoptosis pathways, by exerting its effects by promoting rpn-3 expression to enhance the activity of proteasomes and down-regulating egl-1 expression, and has anti-inflammatory mechanism in LPS-activated RAW 264.7 macrophages, by reducing the transcriptional and translational levels of inducible nitric oxide synthase (iNOS) as well as the production of NO. |
| FB08034 | Pinostrobin | 480-37-5 | Pinostrobin, a natural product isolated and purified from the herbs of Cajanus cajan with anti-inflammatory, cytotoxic, anti-hemorrhagic and analgesic activities, exerts a neuroprotective effect against Aβ(25-35)-induced neurotoxicity in PC12 cells, at least in part, via inhibiting oxidative damage and calcium overload, as well as suppressing the mitochondrial pathway of cellular apoptosis, and can inhibit HSV-1 replication with 50% effective concentration (EC(50)) of 22.71 ± 1.72 ug/mL. |
| FB10427 | Orobol | 480-23-9 | Orobol, a natural product isolated and purified from the herb of Wisteria sinensis, has sensitization effect may be by mitochondrial alterations in these cells, produces cisplatin sensitivity in human ovarian carcinoma cells by inducing apoptosis through the MT-dependent signaling pathway, and regulate PX sensitivity by reciprocally altering the proportion of tubulin isotype expression and PX-induced apoptotic signaling. |
| FB07897 | Orientin | 28608-75-5 | Orientin, a natural product isolated and purified from the herbs of Polygonum orientale Linn., is a candidate therapeutic agent for treatment of vascular inflammatory diseases via inhibition of the HMGB1 signaling pathway, protects vascular barrier integrity by inhibiting hyperpermeability, expression of CAMs, and adhesion and migration of leukocytes, thereby endorsing its usefulness as a therapy for vascular inflammatory diseases, has neuroprotection effect by the intracellular mediation of caspase activity and may alleviate cognitive deficits and oxidative stress in AD mice and can exert antidepressant-like effects on CUMS mice, specifically by improving central oxidative stress, neurotransmission, and neuroplasticity. |
| FB11467 | Nepitrin | 569-90-4 | Nepitrin is isolated from salvia plebeia R.Br. with antioxidant activity. |
| FB10767 | Quercetin-3-O-glucuronide | 22688-79-5 | Miquelianinis a metabolite of quercetin and a type of natural flavonoid which blocks β2-adrenergic signaling. |
| FB11511 | Methylophiopogonone B | 74805-89-3 | Methylophiopogonone B is a natural product from ophiopogon japonicus. |
| FB04743 | Medicarpin | 32383-76-9 | Medicarpin, a natural product isolated and purified from the herb of Hedysarum polybotrys Hand. |
| FB04659 | Licoricidin | 30508-27-1 | Licoricidin, a natural product isolated and purified from the roots of Glycyrrhiza uralensis., inhibits lung metastasis of 4T1 mammary carcinoma cells, which may be mediated via inhibition of cancer cell migration, tumor angiogenesis, and lymphangiogenesis., and also blocks UVA-induced photoaging via ROS scavenging,this activity converges to limit the activity of MMP-1, suggests that licoricidin may be considered as an active ingredient in topically applied anti-ageing formulations. |
| FB10760 | Kuwanon A | 62949-77-3 | Kuwanon A is a flavone derivative isolated from the root barks of the mulberry tree (Morus alba L.) and inhibits nitric oxide production with IC50 of 10.5 μM. |
| FB11503 | Flemiphilippinin D | 99119-72-9 | Kushenol E can be found in the roots of sophora flavescens Ait. With significant antioxidant potentials. |
| FB03804 | Kaempferol 3-O-Arabinoside | 5041-67-8 | Kaempferol 3-O-arabinoside is a natural product isolated and purified from the roots of Ligusticum jeholense Nakai et Kitag displaying cytotoxic and high antioxidant activity. |
| FB03804 | Kaempferol 3-O-Arabinoside | 5041-67-8 | Kaempferol 3-O-arabinoside is a natural product isolated and purified from the roots of Ligusticum jeholense Nakai et Kitag displaying cytotoxic and high antioxidant activity. |
| FB04655 | Juglanin | 5041-67-8 | Juglanin, a natural product isolated and purified from the herbs of Phymatopteris hastate with antioxidant activity, shows protective effects on fructose-induced hepatitis by inhibiting inflammation and apoptosis through TLR4 and JAK2/STAT3 signaling pathways in fructose-fed rats, and can lead to G2/M phase arrest, induce apoptosis as well as autophagy through the ROS/JNK signaling pathway in human breast cancer cells, it may be a promising candidate for development of anti-tumor drugs targeting breast cancer. |
| FB04655 | Juglanin | 5041-67-8 | Juglanin, a natural product isolated and purified from the herbs of Phymatopteris hastate with antioxidant activity, shows protective effects on fructose-induced hepatitis by inhibiting inflammation and apoptosis through TLR4 and JAK2/STAT3 signaling pathways in fructose-fed rats, and can lead to G2/M phase arrest, induce apoptosis as well as autophagy through the ROS/JNK signaling pathway in human breast cancer cells, it may be a promising candidate for development of anti-tumor drugs targeting breast cancer. |
| FB05752 | Isoerysenegalensein E | 478158-77-9 | Isoerysenegalensein E is a natural product isolated and purified from the herbs of Erythrina indica, showing significant cytotoxicity against HL-60 cells, it induces apoptosis in HL-60 cells through activation of the caspase-9/caspase-3 pathway, which is triggered by mitochondrial dysfunction, and anti-estrogenic activity comparable to that of 4-hydroxytamoxifen, a typical estrogen receptor antagonist. |
| FB05178 | Isoangustone A | 129280-34-8 | Isoangustone A, a natural product isolated and purified from the roots of Licorice with antitumor activity, induces G1 cycle arrest in DU145 human prostate and 4T1 murine mammary cancer cells, dampens mesangial sclerosis associated with inflammation in response to high glucose through hindering TGF-β and NF-κB signaling, inhibits cell proliferation by targeting PI3K, MKK4, and MKK7 in human melanoma and shows strong ferric reducing activities and effectively scavenged DPPH, ABTS(+), and singlet oxygen radicals. |
| FB07587 | Hesperetin | 520-33-2 | Hesperetin is a flavanone extracted from the peel of citrus that exhibits inhibition of PDE4 and UGT. Hesperetin has antioxidative and anti-inflammatory effects as well. Hesperetin dose-dependently inhibited cleavage activity of the 3CLpro with IC50 value of 8.3μM in the cell-based assay. |
| FB02439 | Herbacetin | 527-95-7 | Herbacetin, a natural product isolated and purified from the herbs of Equisetum hyemale L. It was found to efficiently block the enzymatic activity of SARS-CoV 3CLpro. |
| FB05176 | Glabrene | 60008-03-9 | Glabrene, a natural product isolated and purified from the roots of Glycyrrhiza uralensis with estrogen-like activity, can stimulate DNA synthesis in human endothelial cells (ECV-304; E304) and has a bi-phasic effect on proliferation of human vascular smooth muscle cells (VSMC), exerts varying degrees of inhibition on tyrosinase-dependent melanin biosynthesis, suggesting that it may serve as candidates for skin-lightening agents. |
| FB05176 | Glabrene | 60008-03-9 | Glabrene, a natural product isolated and purified from the roots of Glycyrrhiza uralensis with estrogen-like activity, can stimulate DNA synthesis in human endothelial cells (ECV-304; E304) and has a bi-phasic effect on proliferation of human vascular smooth muscle cells (VSMC), exerts varying degrees of inhibition on tyrosinase-dependent melanin biosynthesis, suggesting that it may serve as candidates for skin-lightening agents. |
| FB06618 | Gallocatechin Gallate | 5127-64-0 | Gallocatechin gallate is a natural product isolated and purified from the herbs of Celastrus orbiculatus with strong antioxidative activity, can decrease osteoclastogenesis at 20 mM, it has positive effects on bone metabolism through a double process of promoting osteoblastic activity and inhibiting osteoclast differentiations, have anti-diabetic effects by increasing sensitivity of insulin, and gallocatechin gallate is more active than epigallocatechin gallate. |
| FB05719 | Ficusin A | 173429-83-9 | Ficusin A is a natural product isolated and purified from the seeds of Psoralea corylifolia Linn. |
| FB05736 | Farrerol | 24211-30-1 | Farrerol is a natural product isolated and purified from the leaves of Rhododendron dauricum L. |
| FB10433 | Eupatorin | 855-96-9 | Eupatorin, a natural product isolated and purified from the herbs of Eupatorium semiserratum, inhibits cell proliferation in human tumor cells, has meaningful anti-inflammatory property which may be utilized in the development of anti-inflammatory treatments, and induces cell death imediated by both the extrinsic and the intrinsic apoptotic pathways and through a mechanism dependent on reactive oxygen species generation. |
| FB04640 | Dalbergioidin | 30368-42-4 | Dalbergioidin, a natural product isolated and purified from the roots of Parochetus communis with tyrosinase inhibitory activity with an IC50 of 20 mM, shows a melanin biosynthesis inhibition zone in the culture plate of Streptomyces bikiniensis that has commonly been used as an indicator organism, protects MC3T3-E1 osteoblastic cells against H2O2-induced cell damage through activation of the PI3K/AKT/SMAD1 pathway, and ameliorates doxorubicin-induced renal fibrosis by suppressing the TGF-β signal pathway. |
| FB06099 | Cycloheterophyllin | 36545-53-6 | Cycloheterophyllin, a natural product isolated and purified from the herbs of Artocarpus heterophyllus, exerts a concentration-dependent inhibition of neutrophil cytosolic protein kinase C (PKC) and rat brain PKC by the O2- generation in rat neutrophils, but has no effect on porcine heart protein kinase A (PKA). |
| FB11401 | Camelliaside A | 135095-52-2 | Camelliaside A is a flavonol triglycoside isolated from seeds of Camellia sinensis. |
| FB05436 | Boeravinone B | 114567-34-9 | Boeravinone B is a natural product isolated and purified from the roots of Boerhaavia coccinea, exhibits significant anti-inflammatory activity (56.6% at 50 mg/kg) when evaluated in an in vivo carrageenan-induced rat paw model ,and is an efflux pump inhibitor, apart from inhibiting the MdeA mediated efflux, also significantly inhibit the biofilm formation of S. |
| FB10456 | Amentoflavone | 1617-53-4 | Amentoflavone is an inhibitor of human UDP-glucuronosyltransferases with anti-inflammatory, antioxidative, and neuroprotective effects and it can be isolated from the seeds of Ginkgo biloba L. Amentoflavone inhibited SARS-CoV 3CL(pro) with IC50 value of 8.3μM. |
| FB03090 | Afzelin | 482-39-3 | Afzelin is a natural product isolated and purified from the herbs of thesium chinense Turcz. |
| FB04342 | 8-Prenylnaringenin | 53846-50-7 | 8-Prenylnaringenin is a phytoestrogen isolated and purified from the herbs of Humulus lupulus with the highest estrogenic activity, shows slight activity in this assay but significant activity by immunostaining, improves mitochondrial function, whereas a high dose of XN (5 µM) worsens the functionality of this organelle, and has more potent effects on promoting osteoblastic bone formation and inhibiting osteoclastic bone resorption by ERα instead of ERβ than the two classic phytoestrogens: genistein and daidzein. |
| FB04649 | 8-Prenylkaempferol | 28610-31-3 | 8-Prenylkaempferol, a natural product isolated and purified from the roots of Sophora flavescens, is an effective agent for attenuating pro-inflammatory NO induction, induces differentiation/maturation of MC3T3-E1 osteoblasts by BMP-2/p38/Runx2 pathways, and may be an anti-inflammatory agent for suppressing influenza A virus-induced RANTES production acts by blocking PI3K-mediated transcriptional activation of NF-κB and IRF-3 and in part by interfering with IκB degradation which subsequently decreases NF-κB translocation. |
| FB11446 | 8-Hydroxyapigenin | 41440-05-5 | 8-Hydroxyapigenin is a flavone found in cupuaçu (Theobroma grandiflorum) and in the liverwort marchantia berteroana. |
| FB16149 | 7-Hydroxyflavone | 6665-86-7 | 7-Hydroxyflavone is a flavonoid isolated from M. indica, with anti-inflammatory activity. 7-Hydroxyflavone protects renal cells from nicotine (NIC)-associated cytotoxicity via the ERK/Nrf2/HO-1 pathway . |
| FB01010 | 5,7-Dihydroxychromone | 31721-94-5 | 5,7-Dihydroxychromone, a natural product isolated and purified from the bark of Garcinia cambogia., exerts neuroprotective effect against 6-OHDA-induced oxidative stress and apoptosis by activating Nrf2/ARE signal, and induces the translocation of Nrf2 to the nucleus and increases Nrf2/ARE binding activity which results in the up-regulation of the expression of Nrf2-dependent antioxidant genes, including HO-1, NQO1, and GCLc. |
| FB06101 | 5,7,3',4'-Tetrahydroxy-3-Methoxy-8,5'-Diprenylflavone | 1353676-65-9 | 5,7,3',4'Tetrahydroxy-3-methoxy-8,5'diprenylflavone, a natural product isolated and purified from the barks of Broussonetia papyrifera, shows potent anti-proliferation effects on ER-positive breast cancer MCF-7 cells in vitro, with the IC50 value of 4.41 uM, and can strongly down-regulate expression concentrations of estrogen receptor-α (ER-α) and is able to inhibit tumor growth in a xenograft model of the human breast cancer line BCAP-37 in vivo. |
| FB01328 | 2'-Hydroxygenistein | 1156-78-1 | 2'-hydroxygenistein, a natural product isolated and purified from the roots of Lupinus mutabilis with antifungal activity, exhibits greater antiproliferative effects in MCF-7 human breast cancer cells than does genistein, and shows significant concentration-dependent inhibitory effects on the release of beta-glucuronidase and lysozyme from rat neutrophils in response to formyl-Met-Leu-Phe/cytochalasin B. |
| FB03703 | 2'-Hydroxydaidzein | 7678-85-5 | 2'-Hydroxydaidzein is an isoflavonoid phytoalexin isolated and purified from the herbs of Crotalaria pallida. |
| FB03710 | 2',3,5,6',7-Pentahydroxyflavanone | 80366-15-0 | 2',3,5,6',7-Pentahydroxyflavanone is a natural product isolated and purified from the roots of Scutellaria baicalensis Georgi which can inhibit the histamine release from rat mast cells induced by compound 48/80. |