CAS:22204-53-1Naproxen

Synonyms: (S)-Naproxen

Naproxen is a COX inhibitor for COX1/2 with IC50 of 8.7 and 5.2 μM, respectively.

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18817579266

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实验数据

技术信息

CAS号

22204-53-1

储存条件

分子式

C14H14O3

运输

蓝冰

分子量

230.26

别名

(S)-Naproxen

溶解度

DMSO	100.0 mg/mL (434.3 mM) warming
Water	insoluble

动物实验配方

IP	2% DMSO+2% Tween80+40% PEG300+water	10 mg/mL	clear
PO	0.5% CMC-Na	56 mg/mL	suspension

生物活性

靶点 COX2

IC50:5.2μM COX1

IC50:8.7μM
描述Naproxen is a well known nonsteroidal anti-inflammatory drug. Naproxen is approximately equipotent inhibitor of COX-1 and COX-2 in intact cells with IC50s of 2.2 μg/mL and 1.3 μg/mL, respectively^[3]. Both JNJ7777120 and naproxen exert an anti-inflammatory and antifibrotic effect that is increased by their combination, which could be an effective therapeutic strategy in the treatment of pulmonary fibrosis^[4]. The IC(50) values (95% CI) of naproxen for analgesia (27 (0-130) μM), antipyretics (40 (30-65) μM) and inhibition of PGE(2) (13 (6-45) μM) were in similar range, whereas inhibition of TXB(2) (5 (4-8) μM) was observed at lower concentrations. Variability in the behavioral measurement of analgesia was larger than for the other endpoints^[3]. Moreover, success rate on the treatment of neoplastic fever using naproxen was 94.1% (95% CI: 87.6%-97.3%). The success rate of the suspected neoplastic fever was 79.8%; for fever of unknown origin, it also reached 67.7%. Besides, a small dose of 125 mg naproxen, 375 mg twice a day and 250 mg 3 times a day were also useful^[5].

靶点	Description	IC50
COX2		IC50:5.2μM
COX1		IC50:8.7μM