| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| FB16046 | PTC596 | 1610964-64-1 | PTC596 is an orally active and selective B-cell-specific Moloney murine leukemia virus integration site 1 (BMI-1) inhibitor. PTC596 targets BMI1 expressed by both tumor cells and cancer stem cells (CSCs), and induces hyper-phosphorylation of BMI1, leading to its degradation. PTC596 downregulates MCL-1 and induces p53-independent mitochondrial apoptosis in acute myeloid leukemia progenitor cells[1][2]. |
| FB12605 | PTC-028 | 1782970-28-8 | PTC-028 can decrease BMI-1 levels by posttranslational modification. |