CAS:198470-84-7Parecoxib

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Synonyms: SC-69124

Parecoxib is a potent and selective COX2 inhibitor.

规格	价格	促销价格	库存

18817579266

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18817579266

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实验数据

技术信息

CAS号

198470-84-7

储存条件

分子式

C19H18N2O4S

运输

蓝冰

分子量

370.42

别名

SC-69124

溶解度

动物实验配方

生物活性

描述Parecoxib is a potent and selective COX-2 inhibitor. Parecoxib ameliorated postischemic mitochondria-mediated neuronal apoptosis induced by focal cerebral ischemia in rats and this neuroprotective potential is involved in phosphorylation of Akt and GSK-3β^[3]. The prodrug Parecoxib as well as its active metabolite val have a specific affinity to the cannabinoid (CB) receptor measured in CB1-expressing HEK 293 cells and rat brain tissue. The analgesic effects of par and its metabolite val in Wistar rats may be at least partially mediated by a direct interaction with the CB1 receptors^[4]. The COX-2 inhibitor parecoxib exerts its analgesic effect on surgical pain through the inhibition of neuronal ERK activation in the spinal cord. COX-2 inhibitor delivery prior to surgery has more potent analgesic effects^[5]. Despite the absence of clinical adverse effects, parecoxib can impair anastomotic and abdominal wound healing on a histopathological level^[6].