3C-like proteinase is a family of enzymes found in the Coronavirus polyprotein. It cleaves the polyprotein at two self-cleavage sites. It is a cysteine protease under clan PA, MEROPS classification C30. In coronaviruses, it is nonstructural protein number 5 (nsp5).
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| FB01030 | Zanamivir | 139110-80-8 | Zanamivir is the first of two registered neuraminidase inhibitors for the treatment and prophylaxis of influenza. Zanamivir could inhibit SARS-CoV-2 3CLpro main protease. |
| FB16798 | Theaflavin-3,3'-digallate | 30462-35-2 | Theaflavin-3,3'-digallate is a tea extract. Theaflavin-3,3'-digallate inhibited 3CLpro with IC50 value of 9.5μM in a fluorogenic substrate peptide assay. |
| FB09657 | Tanshinone IIB | 17397-93-2 | Tanshinone IIB (TSB), a natural product isolated and purified from the roots of Salvia miltiorrhiza, can significantly inhibit the DNA laddering, cytotoxicity and apoptosis of rat cortical neurons induced by staurosporine in a concentration-dependent manner. Tanshinone IIB showed inhibitory effect on PL(pro) with IC50 value of 10.7μM and less inhibitory effect on 3CLpro with IC50 value of 24.8μM. |
| FB00785 | Tanshinone IIA Sulfonate Sodium | 69659-80-9 | Tanshinone IIA sulfonate sodium is a water-soluble derivative of tanshinone IIA, which acts as an inhibitor of store-operated Ca2+entry (SOCE), and is used to treat cardiovascular disorders. |
| FB03031 | Tanshinone IIA | 568-72-9 | Tanshinone IIA is a naturally occuring cardioprotective agent which can inhibit NF-κB and AP-1 DNA binding and display antioxidant and anti-inflammatory properties. Tanshinone IIA showed inhibitory effect on PL(pro) with IC50 value of 1.6μM and less inhibitory effect on 3CLpro with IC50 value of 89.1μM. |
| FB06333 | Tanshinone I | 568-73-0 | Tanshinone I, an active principle isolated from the roots of Salvia miltiorrhiza (Danshen), is an inhibitor of type IIA human recombinant sPLA2 and rabbit recombinant cPLA2 with IC50s of 11 μM and 82 μM, respectively, is structurally similar to tanshinone IIA and may possess similar cytotoxic effects on tumor cells. Tanshinone I showed inhibitory effect on PL(pro) with IC50 value of 8.8μM and less inhibitory effect on 3CLpro with IC50 value of 38.7μM. |
| FB09201 | Saquinavir Mesylate | 149845-06-7 | Saquinavir mesylate is an HIV Protease inhibitor used in antiretroviral therapy. Saquinavir could inhibit SARS-CoV-2 3CLpro main protease. |
| FB09200 | Saquinavir | 127779-20-8 | Saquinavir is an HIV Protease inhibitor used in antiretroviral therapy. Saquinavir could inhibit SARS-CoV-2 3CLpro main protease. |
| FB16811 | Rupintrivir | 223537-30-2 | Rupintrivir is a novel human Rhinovirus 3C Protease inhibitor and exhibited antiviral activity against HRV clinical isolates and HEV a mean EC50 of 24 nM (range, 3 to 104 nM) and a mean EC50 of 41 nM (range, 7 to 137 nM), respectively, in H1-HeLa cell protection assays. |
| FB16797 | Rosmariquinone | 27210-57-7 | Rosmariquinone showed inhibitory effect on PL(pro) and 3CLpro with IC50 values of 30μM and 21.1μM, respectively. |
| FB02412 | Rhoifolin | 17306-46-6 | Rhoifolin, a natural product isolated and purified from the leaves of Turpinia arguya Seem, hows monolithic proliferation inhibitory activities against Hela, A549 and MCF-7 cell lines, and may be beneficial for diabetic complications through their enhanced adiponectin secretion, tyrosine phosphorylation of insulin receptor-β and GLUT4. It was found to efficiently block the enzymatic activity of SARS-CoV 3CLpro. |
| FB10924 | GS-5734 | 1809249-37-3 | Remdesivir is an nucleotide-analog antiviral prodrug. Remdesivir could inhibit SARS-CoV-2 3CLpro main protease. |
| FB08038 | Pectolinarin | 28978-02-1 | Pectolinarigenin, a natural product isolated and purified from the herbs of Cirsium japonicum DC., possesses hepatoprotective and anti-inflammatory activity. |
| FB16795 | Methyl tanshinonate | 18887-19-9 | Methyl tanshinonate showed inhibitory effect on PL(pro) with IC50 value of 9.2μM and less inhibitory effect on 3CLpro with IC50 value of 21.1μM. |
| FB02876 | Indinavir | 150378-17-9 | Indinavir is a potent and specific HIV protease inhibitor that appears to have good oral bioavailability. Indinavir could inhibit SARS-CoV-2 3CLpro main protease. |
| FB07587 | Hesperetin | 520-33-2 | Hesperetin is a flavanone extracted from the peel of citrus that exhibits inhibition of PDE4 and UGT. Hesperetin has antioxidative and anti-inflammatory effects as well. Hesperetin dose-dependently inhibited cleavage activity of the 3CLpro with IC50 value of 8.3μM in the cell-based assay. |
| FB02439 | Herbacetin | 527-95-7 | Herbacetin, a natural product isolated and purified from the herbs of Equisetum hyemale L. It was found to efficiently block the enzymatic activity of SARS-CoV 3CLpro. |
| FB16547 | GC376 | 1416992-39-6 | GC376 is a 3CLpro (3C-like protease) inhibitor that shows promise in treating cats with certain presentations of FIP and has opened the door to targeted antiviral drug therapy. |
| FB16820 | FL-166 | 693235-40-4 | FL-166 inhibited SARS-associated 3CLpro with Ki value of 0.04μM. |
| FB16819 | FL-078 | 693235-36-8 | FL-078 inhibited SARS-associated 3CLpro with Ki value of 4.5μM. |
| FB08426 | Disulfiram | 97-77-8 | Disulfiram is a specific inhibitor of aldehyde-dehydrogenase (ALDH1), used for the treatment of chronic alcoholism by producing an acute sensitivity to alcohol. Disulfiram acts as an allosteric inhibitor of MERS-CoV PLpro but as a competitive (or mixed) inhibitor of SARS-CoV PLpro. |
| FB03859 | Dihydrotanshinone I | 87205-99-0 | Dihydrotanshinone I, a natural product isolated and purified from the roots of Salvia miltiorrhiza Bge., exhibits dose-dependent inhibition towards HLM-catalyzed propofol glucuronidation. Dihydrotanshinone I showed inhibitory effect on PL(pro) with IC50 value of 4.9μM and less inhibitory effect on 3CLpro with IC50 value of 14.4μM. |
| FB16816 | Dieckol | 88095-77-6 | Dieckol exhibited SARS-CoV 3CL(pro) trans/cis-cleavage inhibitory effects with IC50 values of 2.7 and 68.1 μM, respectively. It formed extremely strong hydrogen bonds to the catalytic dyad (Cys145 and His41) of the SARS-CoV 3CL(pro). |
| FB06745 | Cryptotanshinone | 35825-57-1 | Cryptotanshinone is a potent STAT3 inhibitor (IC50 =4.6 μM) and inhibits STAT3 Tyr705 phosphorylation in DU145 prostate cancer cells. Cryptotanshinone showed inhibitory effect on PL(pro) with IC50 value of 0.8μM and slight inhibitory effect on 3CLpro with IC50 value of 226.7μM. |
| FB16823 | CE-5 | 1087243-14-8 | CE-5 blocks MERS-CoV 3CLpro activity with EC50 value of ∼12.5 μM. It inhibited SARS 3CLpro activity with IC50 value of 30nM and exhibited antiviral effect with EC50 value of 6.9μM. |
| FB16801 | Cbz-AVLQ-CN | 1421332-36-6 | Cbz-AVLQ-CN is a peptidomimetic inhibitor which has broad-spectrum inhibition against 3CL(pro) from human coronavirus strains 229E, NL63, OC43, HKU1, and infectious bronchitis virus, with IC(50) values ranging from 1.3 to 3.7 μM. |
| FB10456 | Amentoflavone | 1617-53-4 | Amentoflavone is an inhibitor of human UDP-glucuronosyltransferases with anti-inflammatory, antioxidative, and neuroprotective effects and it can be isolated from the seeds of Ginkgo biloba L. Amentoflavone inhibited SARS-CoV 3CL(pro) with IC50 value of 8.3μM. |
| FB09431 | Aloe-Emodine | 481-72-1 | Aloe-emodin, a natural product isolated and purified from the root of Rheum palmatum L. with a specific in vitro and in vivo anti-neuroectodermal tumor activity, reduces the toxicity and ROS induced by both monomeric and oligomeric Aβ species, appears to have some protective effect not only against hepatocyte death but also on the inflammatory response subsequent to lipid peroxidation and has a strong non-carcinogenic stimulant-laxative action when applied to the skin, although it may increase the carcinogenicity of some kind of radiation. Aloe-Emodine dose-dependently inhibited cleavage activity of the 3CLpro with IC50 value of 366μM in the cell-based assay. |
| FB16807 | AcNSTSQ-H | N/A | AcNSTSQ-H is a SARS-CoV 3CLpro inhibitor with IC50 value of 7.5μM. |
| FB16808 | AcESTLQ-H | N/A | AcESTLQ-H is a SARS-CoV 3CLpro inhibitor with IC50 value of 7.5μM. |
| FB16806 | A38120 | 393540-75-5 | A38120 is a 3CLpro inhibitor with IC50 values of 2 ± 0.4μM and 11.9 ± 3.5μM for 3CLpro of SARS and TGEV, respectively. |
| FB16810 | 3CLpro inhibitor 12d | 1348639-12-2 | 3CLpro inhibitor 12d inhibited SARS 3CLpro with IC50 value of 28μM. |
| FB16809 | 3CLpro inhibitor 11d | 1349571-70-5 | 3CLpro inhibitor 11d inhibited SARS 3CLpro with IC50 value of 13μM. |
| FB16799 | 3CLpro inhibitor 13b | 2412965-59-2 | 3CLpro inhibitor compound 13b inhibited the purified recombinant SARS-CoV2 3CLpro with IC50 value of 0.67 ± 0.18μM. Also it inhibitied the SARS-CoV 3CLpro and the MERS-CoV 3CLpro with IC50 values of 0.90 ± 0.29μM and 0.58 ± 0.22μM, respectively. It binds the substrate-binding cleft of 3CLpro. |
| FB16824 | 3CLpro inhibitor 9 | 489464-52-0 | 3CLpro inhibitor 9 is a 3CLpro inhibitor with IC50 value of 18.2 ± 4.9μM (SARS‐CoV 3CLpro). It binds to the active site of 3CLpro. |
| FB16804 | 3CLpro inhibitor 8k1 | 1529815-13-1 | 3CLpro inhibitor 8k1 is an isatin-derived SARS-CoV 3CL(pro) inhibitor with IC50 value of 1.04μM measued by in vitro protease assay using fluorogenic substrate peptide. |
| FB16805 | 3CLpro inhibitor 7 | 384369-45-3 | 3CLpro inhibitor 7 is a competitive inhibitor of 3CLpro with Ki value of 9.93 ± 0.44μM. It interacts with amino acid residues in the active site of 3CLpro through hydrophobic and hydrogen bond. |
| FB16826 | 3CLpro inhibitor 6d | 1065478-52-5 | 3CLpro inhibitor 6d is a peptidomimetic inhibitor of enterovirus 3Cpro. It also inhibited MERS-CoV 3CLpro and SARS-CoV 3CLpro with IC50 values ranging from 1.7 to 4.7 μM and from 0.2 to 0.7 μM, respectively. |
| FB16803 | 3CLpro inhibitor 6 | 324566-35-0 | 3CLpro inhibitor 6 is a competitive inhibitor of 3CLpro with Ki value of 9.11± 1.61μM. It interacts with amino acid residues in the active site of 3CLpro through hydrophobic and hydrogen bond. |
| FB16817 | 3CLpro inhibitor 3g | 1945974-05-9 | 3CLpro inhibitor 3g could inhibit H5N1 neuraminidase with IC50 of 2.9μM, as well as inhibited SARS 3CLpro and MERS 3CLpro with IC50 values of 20.2 ± 0.3μM and 10.1 ± 1.8μM, respectively. |
| FB16818 | 3CLpro inhibitor 3f | 1945974-03-7 | 3CLpro inhibitor 3f could inhibit H5N1 neuraminidase with IC50 of 2.8μM, as well as inhibited SARS 3CLpro and MERS 3CLpro with IC50 values of 16.4 ± 0.7μM and 12.2 ± 2.2μM, respectively. |
| FB16815 | 3CLpro inhibitor 14 | 2993-05-7 | 3CLpro inhibitor 14 is a 3CLpro inhibitor with IC50 value of 13.9 ± 2.2μM (SARS‐CoV 3CLpro). |
| FB16802 | 3-isotheaflavin-3-gallate | 220473-67-6 | 3-isotheaflavin-3-gallate is a tea extract. It inhibited 3CLpro with IC50 value of 7μM in a fluorogenic substrate peptide assay. |
| FB16800 | 16-(R)-ML188 | 1417700-13-0 | 16-(R)-ML188 is a non-covalent SARS-CoV 3CLpro inhibitor with good enzyme and antiviral inhibitory activity. |
| FB18304 | 16-(S)-ML188 | 1417700-12-9 |