E1/E2/E3 Enzyme
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| FB15273 | VL285 | 1448188-57-5 | VL285 is a potent VHL ligand, degrading HaloTag7 fusion proteins. |
| FB11278 | VH-298 | 2097381-85-4 | VH-298 is a highly affinity inhibitor of E3 ubiquitin ligase VHL inhibitor (Kd = 80-90 nM) which can block the interaction of VHL and HIF-α, thus initiating hypoxic response. |
| FB10825 | UbcH5c Inhibitor C6d | N/A | UbcH5c inhibitor C6d exhibits potent anti-inflammatory activity against complete Freund's adjuvant-induced adjuvant arthritis in vivo and is a promising lead compound for the development of anti-rheumatoid arthritis (RA) agent. |
| FB01914 | TZ9 | 1002789-86-7 | TZ9 is an inhibitor of Rad6 ubiquitin conjugating enzyme (E2 enzyme) and inhibits MDA-MB-231 cell proliferation with IC50 of ~6 μM. |
| FB11889 | E3 Ligand-Linker Conjugate 10 | 1957236-22-4 | Thalidomide-O-amido-PEG4-C2-Amine is a PROTAC block consist of Thalidomide and a linker with Amine functional group for conjugation reactions. |
| FB11892 | E3 Ligand-Linker Conjugate 9 | 1957236-20-2 | Thalidomide-O-amido-PEG3-C2-Amine is a PROTAC block consist of Thalidomide and a linker with an Amine functional group for conjugation reactions. |
| FB11893 | E3 Ligand-Linker Conjugate 8 | 1957235-74-3 | Thalidomide-O-amido-PEG2-C2-Amine is a PROTAC block consist of Thalidomide and a linker with Amine functional group for conjugation reactions. |
| FB11894 | E3 Ligand-Linker Conjugate 7 | 2022182-59-6 | Thalidomide-O-amido-PEG-C2-Amine is a PROTAC block consist of Thalidomide and a linker with Amine functional group for conjugation reactions. |
| FB11891 | E3 Ligand-Linker Conjugate 1 | 2098488-36-7 | Thalidomide-O-amido-C4-Azide is a PROTAC block consist of Thalidomide linked to alkyl with an Azide functional group for conjugation reactions. |
| FB11897 | E3 Ligand-Linker Conjugate 3 | 1799711-24-2 | Thalidomide-O-amido-C4-Amine is a PROTAC block consist of Thalidomide linked to alkyl with Amine functional group for conjugation reactions. |
| FB11895 | E3 Ligand-Linker Conjugate 6 | 2022182-57-4 | Thalidomide-O-amido-C3-Amine is a PROTAC block consist of Thalidomide linked to alkyl with Amine functional group for conjugation reactions. |
| FB18837 | Thalidomide-NH-C4-NH-Boc | 2093388-52-2 | Thalidomide-NH-C4-NH-Boc is a PROTAC block consist of Thalidomide with a Boc functional group for conjugation reactions. |
| FB16025 | Thalidomide-linker 2 | 2245697-85-0 | Thalidomide-linker 2 is a PROTAC block consist of Thalidomide and a linker with Amine functional group for conjugation reactions. |
| FB12099 | Teslexivir | 1075798-37-6 | Teslexivir is a topical antiviral agent that is a potent and selective inhibitor of the interaction between two essential viral proteins, E1 and E2, an interaction that is a necessary step for Human Papilloma Virus (HPV) 6 and 11 DNA replication and thus viral production. |
| FB11370 | E3 ligase Ligand 3 | 1061605-21-7 | TC E3 5031 is a thalidomide derivate for conjugation reactions of PROTAC, which can hijack cereblon as the E3 ubiquitin ligase component. |
| FB15606 | TAK-981 | 1858276-04-6 | TAK-981 is a first in class and selective inhibitor of the SUMOylation enzymatic cascade, with potential immune-activating and antineoplastic activities. |
| FB11530 | TAK-243 | 1450833-55-2 | TAK-243, also known as MLN7243 and AOB87172, is a small molecule inhibitor of ubiquitin-activating enzyme (UAE), with potential antineoplastic activity. |
| FB00654 | SZL P1-41 | 222716-34-9 | SZL P1-41 is Skp2 inhibitor, selectively suppresses Skp2 E3 ligase activity, but not activity of other SCF complexes. |
| FB15542 | Smurf1-IN-A01 | 1007647-73-5 | Smurf1-IN-A01 is an inhibitor of negatively regulatory factor Smurf1 for promoting bone formation. |
| FB17159 | SMER 3 | 67200-34-4 | SMER 3 is a selective inhibitor of yeast SCF family E3 ubiquitin ligase (SCFMet30) in vitro and in vivo. |
| FB01639 | PYZD-4409 | 423148-78-1 | PYZD-4409 is a small molecule inhibitor of Ubiquitin-activating enzyme UBA1/E1 enzyme with an IC50 of 20 μM (cell-free enzymatic assay). |
| FB08805 | PYR-41 | 418805-02-4 | PYR-41 (50 μM) inhibits activity of ubiquitin-activating enzyme E1 by over 90%. |
| FB04881 | PRT4165 | 31083-55-3 | PRT4165, an inhibitor of bim1 and ring1A, could block PRC1 (Polycomb-repressive complex 1)-mediated H2A ubiquitylation. |
| FB12077 | PROTAC Linker 1 | 1835705-53-7 | PROTAC Linker 1 is a linker used to link the warhead and the E3 ligase ligand. |
| FB09268 | PK11195 | 85532-75-8 | PK11195 is a 2‑Phenylindolylglyoxylyldipeptide Murine Double Minute2 (MDM2)/Translocator Protein (TSPO)/Human Constitutive Androstane Receptor (hCAR) Inhibitor, and is potentially useful for the Treatment of Gliomas. |
| FB08868 | NSC 697923 | 343351-67-7 | NSC 697923 is a cell-permeable and selective inhibitor of the Ub-conjugating enzyme (E2) complex Ubc13-Uev1A. |
| FB17160 | N106 | 862974-25-2 | N106 is an activator of SUMO-activating enzyme E1 ligase. It can increase SERCA2a SUMOylation and activity and enhance contractility in rat cardiomyocytes in vitro. |
| FB11288 | ML-792 | 1644342-14-2 | ML-792 is a mechanism-based SUMO-activating enzyme (SAE) inhibitor with nanomolar potency in cellular assays, which selectively blocks SAE enzyme activity and total SUMOylation, thus decreasing cancer cell proliferation. |
| FB18234 | MID-1 | 312608-54-1 | MID-1 is a MG53-IRS-1 interaction disruptor. It abolished MG53-mediated IRS-1 ubiquitination and degradation, as well as sensitized insulin signaling and increased insulin-elicited glucose uptake with an elevated level of IRS-1 in C2C12 myotubes. |
| FB02643 | MDK7526 | 1448297-52-6 | MDK7526 is a ligand of Von Hippel–Lindau protein, that can be used for making proteolysis targeting chimeras (PROTACs). |
| FB17746 | LS-102 | 1456891-34-1 | LS-102 is a selective inhibitor of E3 ubiquitin ligase synoviolin (Syvn1). LS-102 inhibits the autoubiquitination of synoviolin with an IC50 of 35 μM. LS-102 has the potential for rheumatoid arthritis treatment. |
| FB11896 | E3 Ligand-Linker Conjugate 4 | 2093388-45-3 | Lenalidomide-C5-Amine is a PROTAC block consist of Lenalidomide linked to alkyl with Amine functional group for conjugation reactions. |
| FB11890 | E3 Ligand-Linker Conjugate 5 | 2093388-69-1 | Lenalidomide-C4-Amine is a PROTAC block consist of Lenalidomide linked to alkyl with Amine functional group for conjugation reactions. |
| FB12025 | HaloPROTAC 1 | 1799506-06-1 | HaloPROTAC 2 is a PROTAC block consist of VH032 and a linker with chlorine functional group for conjugation reactions. |
| FB11632 | E3 Ligase Ligand 6 | 1631137-51-3 | E3 Ligase Ligand 6 is used for conjugation reactions of PROTAC, which can hijack VHL as the E3 ubiquitin ligase component. |
| FB11378 | E3 ligase Ligand 2 | 5054-59-1 | E3 ligase Ligand 2 is a thalidomide derivate for conjugation reactions of PROTAC, which can hijack cereblon as the E3 ubiquitin ligase component. |
| FB11646 | E3 Ligase Ligand 1A | 1948273-02-6 | E3 ligase Ligand 1A is a VH032 derivate for conjugation reactions of PROTAC, which can hijack VHL as the E3 ubiquitin ligase component. |
| FB11898 | E3 Ligand-Linker Conjugate 2 | 2098492-26-1 | E3 Ligand-Linker Conjugate 2 is a PROTAC block consist of E3 ligase ligand and a linker. |
| FB15391 | COH000 | 1534358-79-6 | COH000 is an irreversible inhibitor of ubiquitin-like 1-activating enzyme (SUMO-activating enzyme) with IC50 of 0.2 μM for SUMOylation in vitro. |
| FB02738 | CC0651 | 1319207-44-7 | CC0651 is an allosteric inhibitor of the human cdc34 ubiquitin-conjugating enzyme that potently (IC50 = 1.72 μM) inhibited the ubiquitination of p27 Kip1. |
| FB17654 | CC-92480 | 2259648-80-9 | CC-92480 is a cereblon E3 ubiquitin ligase modulating drug (CELMoD). CC-92480 shows high affinity to cereblon, resulting in potent antimyeloma activity . |
| FB11867 | CC-885 | 1010100-07-8 | CC-885 is a cereblon (CRBN) modulator with potent anti-tumour activity. |
| FB10946 | CC-220 | 1323403-33-3 | CC-220 is a modulator of cereblon that is potential to treat systemic lupus erythematosis and multiple myeloma. |
| FB08498 | CC-122 | 1015474-32-4 | CC-122, also known as avadomide, binds to CRBN and induces degradation of aiolos and ikaros that result in cell apoptosis. It is a antitumor and immunomodulatory agent used to treat DLBCL. |