Guanylate Cyclase
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| FB07071 | Vericiguat | 1350653-20-1 | Vericiguat targets soluble guanylate cyclase (sGC) and is used for treating heart failure. |
| FB07226 | Riociguat | 625115-55-1 | Riociguat acts as stimulator of soluble guanylate cyclase (sGC) that is used to treat ipulmonary hypertension. |
| FB16862 | Praliciguat | 1628730-49-3 | Praliciguat is a novel, orally available sGC stimulator. It suppresses stellate cell fibrotic transformation and inhibits fibrosis and inflammation in models of NASH. |
| FB11563 | Plecanatide | 467426-54-6 | Plecanatide is an oral guanylate cyclase C agonist acting locally in the gastrointestinal tract, it is approved in January 2017 by the FDA for the treatment of chronic idiopathic constipation (CIC). |
| FB08921 | Linaclotide | 851199-59-2 | Linaclotide is a 14-amino acid peptide indicated for the treatment of adults with CC and IBS-C and an agonist of guanylate cyclase C |
| FB00937 | YC-1 | 170632-47-0 | Lificiguat is an acivator of guanylyl cyclase (sGC) and can bind to the heme-containing domain of the β subunit with Kd of 0.6 μM - 1.1 μM. |
| FB04899 | Cinaciguat | 329773-35-5 | Cinaciguat is the first of a class of soluble guanylate cyclase (sGC) activators in clinical development for acute decompensated heart failure. |
| FB10291 | Cinaciguat HCl | 646995-35-9 | Cinaciguat HCl is a potent soluble guanylate cyclase (GC) activator with EC50 of 15 nM in platelets. |
| FB11687 | BM121307 | 137213-91-3 | BM121307 is a guanylate cyclase activator that was in phase I development for the treatment of ischaemic heart disorders. The research has been discontinued. |
| FB07227 | BAY 41-2272 | 256376-24-6 | BAY 41-2272 is an activator of guanylate cyclases (sGC). |
| FB02004 | Ataciguat | 254877-67-3 | Ataciguat is a potent guanylate cyclase activator potentially for the treatment of aortic valve stenosis. |