PDGFR
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| FB16533 | Tyrphostin AG1433 | 168835-90-3 | Tyrphostin AG1433 is a tyrosine kinases inhibitor and also a selective PDGFRβ and VEGFR-2 (Flk-1/KDR) inhibitor with IC50s of 5.0 μM and 9.3 μM, respectively. |
| FB00746 | Tyrphostin A9 | 10537-47-0 | Tyrphostin 9 is a PDGFR inhibitor with IC50 of 0.5 μM EGFR inhibitor with IC50 of 460 μM, it can induce apoptosis in cancer cells, inhibit the growth of vascular smooth cells and block calcium release-dependent phosphorylations. |
| FB11672 | Tyrosine Kinase-IN-1 | 705946-27-6 | Tyrosine kinase-IN-1 is a multi-targeted tyrosine kinase inhibitor with IC50s of 4, 20, 4, 2 nM for KDR, Flt-1, FGFR1 and PDGFRα, respectively. |
| FB10536 | TSU-68 (Random Configuration) | 252916-29-3 | TSU-68 is a multiple receptor tyrosine kinase inhibitor with IC50 of 2.1 μM, 8 nM and 1.2 μM for VEGF-R1, PDGF-Rβ and FGF-R1, respectively and has greatest potency against PDGFR autophosphorylation. |
| FB06809 | Trapidil | 15421-84-8 | Trapidil, a vasodilator and an antiplatelet drug, is also a PDGF antagonist that can inhibit the proliferation of the PDGF-producing glioma cells. |
| FB02101 | Toceranib Phosphate | 874819-74-6 | Toceranib phosphate is a kinase inhibitor with both antitumor and antiangiogenic activity through inhibition of KIT, vascular endothelial growth factor receptor 2, and PDGFRβ. |
| FB08794 | Toceranib | 356068-94-5 | Toceranib is a kinase inhibitor with both antitumor and antiangiogenic activity through inhibition of KIT, vascular endothelial growth factor receptor 2, and PDGFRβ. |
| FB05328 | Sunitinib Malate | 341031-54-7 | Sunitinib Malate is a multi-targeted RTK inhibitor targeting VEGFR2 (Flk-1) and PDGFRβ with IC50 of 80 nM and 2 nM, and also inhibits c-Kit. |
| FB08519 | Sunitinib | 557795-19-4 | Sunitinib is a multi-targeted RTK inhibitor targeting VEGFR2 (Flk-1) and PDGFRβ with IC50 of 80 nM and 2 nM, and also inhibits c-Kit. |
| FB00105 | SU6668 | 210644-62-5 | SU6668 is a cell-permeable indolinone compound that acts as a potent ATP-competitive inhibitor against RTKs (receptor tyrosine kinases) Kit, PDGFRβ, VEGFR2 (Flk-1/KDR), FGFR1 activity in vitro (IC50 = 0.01, 0.1, 3.9, and 3.8 µM, respectively) and PDGF/VEGF/bFGF-mediated angiogenesis and tumor development. Although initially characterized as an RTK inhibitor, SU6668 is now also known to target ser/thr kinases Aurora A, Aurora B, TBK1 (NAK/T2K), and AMPK (IC50 = 0.85, 0.047, 1.4, and 1.8 µM, respectively), as well as non-receptor TKs Lyn and Yes (IC50 = 4.3 and 5.8 µM, respectively). |
| FB12712 | SU 16f | 251356-45-3 | SU16f is a potent and selective platelet-derived growth factor receptor-β (PDGFRβ) inhibitor[1]. |
| FB08298 | SU14813 Maleate | 849643-15-8 | SU14813 maleate is an oral, multitargeted tyrosine kinase inhibitor (TKI) targeting vascular endothelial growth factor receptors (VEGFR), platelet-derived growth factor receptors (PDGFR), Kit, and fms-like tyrosine kinase 3 (FLT-3). |
| FB02484 | SU14813(Random Configuration) | 627908-92-3 | SU14813 is an oral, multitargeted tyrosine kinase inhibitor (TKI) targeting vascular endothelial growth factor receptors (VEGFR), platelet-derived growth factor receptors (PDGFR), Kit, and fms-like tyrosine kinase 3 (FLT-3). |
| FB11072 | SU11652 | 326914-10-7 | SU11652 is a sunitinib analog with anti-tyrosine-kinase activity, also is identified as a potential inhibitor for Leishmania major (Lm) nucleoside diphosphate kinases NDK and structural studies indicated that this molecule binds to the active site of LmNDK in a similar conformation to nucleotides, mimicking natural substrates. |
| FB18291 | Seralutinib | 1619931-27-9 | Seralutinib is a potent and novel inhaled PDGFR inhibitor, used in the study for pulmonary arterial hypertension. |
| FB03921 | Sennoside B | 128-57-4 | Sennoside B inhibits PDGF-stimulated cell proliferation, it's a kind of irritant laxative isolated from rhei rhizome and leaves of Cassia angustifolia.. |
| FB07010 | PP121 | 1092788-83-4 | PP-121 is a multi-targeted inhibitor of PDGFR, Hck, mTOR, VEGFR2, Src and Abl with IC50 of 2 nM, 8 nM, 10 nM, 12 nM, 14 nM and 18 nM, also inhibits DNA-PK with IC50 of 60 nM. |
| FB01966 | Masitinib Mesylate | 1048007-93-7 | Masitinib Mesylate is an inhibitor for Kit and PDGFRα/β with IC50 of 200 nM and 540/800 nM, weak inhibition to ABL and c-Fms. |
| FB01376 | Masitinib | 790299-79-5 | Masitinib is an inhibitor for Kit and PDGFRα/β with IC50 of 200 nM and 540 nM/800 nM, weak inhibition to ABL and c-Fms. |
| FB12190 | DMPQ 2HCl | 1123491-15-5 | DMPQ 2HCl is a potent and selective inhibitor of human vascular β-type platelet derived growth factor receptor tyrosine kinase (PDGFRβ) with IC50 of 80 nM. |
| FB00581 | Crenolanib | 670220-88-9 | Crenolanib is a potent class III RTKs inhibitor with Kd values of 3.2nM, 2.1nM and 0.74nM for PDGFRα, PDGFRβ and FLT3. |
| FB08737 | CP-673451 | 343787-29-1 | CP-673451 is a selective inhibitor of PDGFRα/β with IC50 of 10 nM/1 nM in cell-free assays, exhibits > 450-fold selectivity over other angiogenic receptors, has antiangiogenic and antitumor activity. |
| FB11094 | CGP-53716 | 152459-94-4 | CGP-53716 is a selective tyrosine kinase inhibitor of PDGFR. |
| FB00748 | AG 1296 | 146535-11-7 | AG 1296 is an inhibitor of PDGFR with IC50 of 0.3-0.5 μM, no activity to EGFR. |
| FB02779 | AC710 Mesylate | 1351522-05-8 | AC710 mesylate is a potent, selective PDGFR-family kinases inhibitor with Kd values of 0.6 nM/1.0 nM/1.3 nM/1.0 nM for FLT3/KIT/PDGFRα/PDGFRβ respectively. |
| FB02778 | AC710 | 1351522-04-7 | AC710 is a potent, selective PDGFR-family kinases inhibitor with Kd values of 0.6 nM/1.0 nM/1.3 nM/1.0 nM for FLT3/KIT/PDGFRα/PDGFRβ respectively. |