FAK
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| FB00493 | Y15 | 4506-66-5 | Y15 is a small molecule FAK phosphorylation inhibitor which specifically block phosphorylation of Y397-FAK and total phosphorylation of FAK. |
| FB12746 | Y 11 | 1086639-59-9 | Y11 is a small molecule inhibitor targeting Y397 site of FAK. Y11 significantly and specifically decreased FAK autophosphorylation, directly bound to the N-terminal domain of FAK. In addition, Y11 decreased Y397-FAK autophosphorylation, inhibited viability and clonogenicity of colon SW620 and breast BT474 cancer cells and increased detachment and apoptosis in vitro. Moreover, Y11 significantly decreased tumor growth in the colon cancer cell mouse xenograft model. Finally, tumors from the Y11-treated mice demonstrated decreased Y397-FAK autophosphorylation and activation of poly (ADP ribose) polymerase and caspase-3. |
| FB04113 | Solanesol | 13190-97-1 | Solanesol is a C45 isoprenoid alcohol, it is the most abundant lipid in tobacco leaves and may be an important precursor of the tumorigenic polynuclear aromatic hydrocarbons of smoke. |
| FB19578 | PROTAC FAK degrader 1 | 2301916-69-6 | PROTAC FAK degrader 1 is a selective and potent PROTAC targeting on Fak with DC50 value of 3nM. It was generated by linking defactinib and VHL ligand. |
| FB08545 | PND-1186 | 1061353-68-1 | PND-1186 is a potent FAK inhibitor with IC50 of 1.5 nM. |
| FB03332 | PF-573228 | 869288-64-2 | PF-573228 is a potent and selective FAK inhibitor with IC50 of 4 nM for inhibiton of purified recombinant catalytic fragment of FAK and inhibits FAK phosphorylation on Tyr(397) with an IC(50) of 30-100 nM. |
| FB08900 | PF-562271 | 717907-75-0 | PF-562271 is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM, ~10-fold less potent for Pyk2 than FAK and > 100-fold selectivity against other protein kinases, except for some CDKs. |
| FB10179 | PF-562271 HCl | 939791-41-0 | PF-562271 HCl is the HCl salt of PF-562271, which is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM, ~10-fold less potent for Pyk2 than FAK and > 100-fold selectivity against other protein kinases, except for some CDKs. |
| FB06665 | PF-562271 Besylate | 939791-38-5 | PF-562271 besylate is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM, ~10-fold less potent for Pyk2 than FAK and > 100-fold selectivity against other protein kinases, except for some CDKs. |
| FB05131 | PF-431396 | 717906-29-1 | PF-431396 is dual focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (PYK2) inhibitor (IC50 values are 2 and 11 nM respectively), PF-431396 has a Kd value of 445 nM for BRD4. |
| FB02457 | NVP-TAE 226 | 761437-28-9 | NVP-TAE 226 is a potent FAK inhibitor with IC50 of 5.5 nM, modestly potent to Pyk2 (IC50=3.5 nM) and 10- to 100-fold less potent against InsR, IGF-1R, ALK, and c-Met. |
| FB09916 | GSK2256098 | 1224887-10-8 | GSK2256098, is a focal adhesion kinase-1 (FAK) inhibitor with potential antiangiogenic and antineoplastic activities. |
| FB01982 | Defactinib | 1073154-85-4 | Defactinib is a potent FAK phosphorylation inhibitor and overcomes YB-1–mediated paclitaxel resistance by an AKT-dependent pathway. |
| FB01983 | Defactinib HCl | 1073160-26-5 | Defactinib HCl is a potent FAK phosphorylation inhibitor and overcomes YB-1–mediated paclitaxel resistance by an AKT-dependent pathway. |
| FB00383 | CEP-37440 | 1391712-60-9 | CEP-37440 is a potent and selective Dual FAK/ALK inhibitor with IC50 s of 2.3 nM (FAK) and 120 nM (ALK cellular IC50 in 75% human plasma). |