Sirtuin
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| FB16407 | UBCS039 | 358721-70-7 | UBCS039 is a specific Sirtuin 6 activator which showed robust activating effects on Sirt6-dependent H3K18ac deacetylation of both full-length histone proteins and complete HeLa nucleosomes. |
| FB11083 | Thiomyristoyl | 1429749-41-6 | Thiomyristoyl is an inhibitor of Sirt2 and Sirt1 with IC50 of 28 nM, 98 μM. |
| FB08331 | SRT1720 HCl | 2060259-60-9 | The maximum activation ratio of SRT1720 versus the closest sirtuin homologues, SIRT2 (EC1.5 = 37 μM) and SIRT3 (EC1.5 > 300 μM) is up to 781%. |
| FB08595 | Tenovin-6 | 1011557-82-6 | Tenovin-6 is the water soluble analog of Tenovin-1 and acts as a potent SIRT1 (IC50=21 μM) and SIRT2 (IC50= 10 μM) inhibitor as well as p53 activator. |
| FB01922 | Tenovin 6 HCl | 1011301-29-3 | Tenovin 6 HCl is the water soluble analog of Tenovin-1 and acts as a potent SIRT1 (IC50=21 μM) and SIRT2 (IC50= 10 μM) inhibitor as well as p53 activator. |
| FB17220 | SRTCX1003 | 1203480-93-6 | SRTCX1003 is a Sirtuin 1 activator. It enhanced deacetylation of cellular p65 protein, which resulted in the suppression of TNFα-induced NF-κB transcriptional activation and reduction of LPS-stimulated TNFα secretion in a SIRT1-dependent manner. |
| FB10248 | SRT3025 HCl | 2070015-26-6 | SRT3025 HCl is an orally available sirtuin modulator. |
| FB10228 | SRT2183 | 1001908-89-9 | SRT2183 is a small-molecule activator of the sirtuin subtype SIRT1. |
| FB02252 | SRT2104 | 1093403-33-8 | SRT2104 is an activator of SIRT1 which is involved in the regulation of energy homeostasis. |
| FB06821 | SRT1720 | 925434-55-5 | SRT1720 is a selective activator of human SIRT1 (EC1.5 = 0.16 μM) versus the closest sirtuin homologues, SIRT2 and SIRT3 (SIRT2: EC1.5 = 37 μM；SIRT3: EC1.5 > 300 μM). |
| FB15749 | SRT1720 2HCl | 1001645-58-4 | SRT1720 2HCl is a selective SIRT1 activator. |
| FB16848 | SRT1460 | 925432-73-1 | SRT1460 is a SIRT1 activator with EC50 value of 2.9μM in an in vitro fluorescence polarization assay. |
| FB10904 | Sirtuin Inhibitor C18 | 1392810-44-4 | Sirtuin inhibitor C18 is a histone deacetylase class III inhibitor of sirtuin 1 and 2 exerting antiproliferative activity against cancer cell lines. |
| FB00371 | Sirtinol | 410536-97-9 | Sirtinol is a specific SIRT1 and SIRT2 inhibitor with IC50 of 131 μM and 38 μM in cell-free assays, respectively. |
| FB19488 | SIRT5 inhibitor 1 | 2166487-21-2 | SIRT5 inhibitor 1 is "drug-like" and potent SIRT5 inhibitor with IC50 value of 0.11μM. |
| FB10203 | SirReal2 | 709002-46-0 | SirReal2 is a potent and selective Sirt2 inhibitor with IC50 of 140 nM. |
| FB10245 | Salermide | 1105698-15-4 | Salermide, a reverse amide, can act as an inhibitor of sirt, especially of sirt2, with the property of inducing apoptosis of tumor cells. |
| FB11925 | Sirt2-PROTAC-1 | 2098487-75-1 | PROTAC Sirt2 Degrader-12 is a PROTAC selectively targeting on Sirt2, consist an isotype-selective Sirt2 inhibitor SirReal as a warhead linked to cereblon ligand thalidomide. |
| FB16668 | OSS_128167 | 887686-02-4 | OSS_128167 is a potent selective sirtuin 6 (SIRT6) inhibitor with IC50s of 89 μM, 1578 μM and 751 μM for SIRT6, SIRT1 and SIRT2, respectively. OSS_128167 has anti-HBV activity that inhibits HBV transcription and replication. OSS_128167 has anti-cancer, anti-inflammation and anti-viral effects. |
| FB20356 | Nicotinamide riboside | 1341-23-7 | Nicotinamide riboside increases NAD[+] levels and activates SIRT1 and SIRT3, culminating in enhanced oxidative metabolism and protection against high fat diet-induced metabolic abnormalities. |
| FB00839 | Nicotinamide | 98-92-0 | Nicotinamide can act as an inhibitor of sirtuins and it is the active component of NAD and NADP. |
| FB08789 | Inauhzin | 309271-94-1 | Inauhzin is a small molecule that effectively reactivates p53 by inhibiting SIRT1 activity, and promotes p53-dependent apoptosis of human cancer cells without causing apparently genotoxic stress (IC50=3 μM, in A549 cell). |
| FB05926 | Fisetin | 528-48-3 | Fisetin is an active flavonol that can be used in the synthesis of pharmaceutical with anti-inflammatory and antiproliferative activities. |
| FB08336 | EX-527 S-Enantiomer | 848193-68-0 | EX-527 S-enantiomer is a potent and selective SIRT1 inhibitor with IC50 of 123 nM, showing no inhibition on SIRT3 and SIRT3. |
| FB08321 | EX-527 R-Enantiomer | 848193-69-1 | EX-527 R-enantiomer is the R-enantiomer of EX-527. EX-527 is a potent and selective SIRT1 inhibitor with IC50 of 38 nM. EX-527 has much lower potency against SIRT2 (IC50, 19.6 μM) or SIRT3 (IC50, 48.7 μM). |
| FB06548 | EX-527 | 49843-98-3 | EX-527 is a potent and selective SIRT1 inhibitor with IC50 of 38 nM, exhibits > 200-fold selectivity against SIRT2 and SIRT3. |
| FB15378 | MDL-800 | 2275619-53-7 | DL-800 is an allosteric and selective SIRT6 activator with EC50 of 10.3μM. |
| FB03410 | AK-7 | 420831-40-9 | AK-7 is a selective and brain-permeable SIRT2 inhibitor and is neuroprotective in Huntington disease mouse models. |
| FB00077 | AK-1 | 330461-64-8 | AK-1 is a cell permeable, benzylsulfonamide that inhibits SIRT2 activity (IC50= 12.5 µM through enzymatic assay) by targeting the SIRT2 nicotinamide binding site, but may also target SIRT1 and SIRT3 (IC50 >40 µM) with much less potency. |
| FB00861 | AGK2 | 304896-28-4 | AGK2 is a potent, and selective SIRT2 inhibitor with IC50 of 3.5 μM that minimally affects either SIRT1 or SIRT3 at 10-fold higher levels. |
| FB02897 | 3-TYP | 120241-79-4 | 3-TYP is a selective inhibitor of SIRT3. |