CAS:53-86-1Indomethacin

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Indomethacin 吲哚美辛 Cat No. FB03453Cas No. 53-86-1

Synonyms: Indocin

Indomethacin is a nonselective COX1 and COX2 inhibitor with IC50 of 0.1 μg/mL and 5 μg/mL, respectively, used to reduce fever, pain, stiffness, and swelling.

规格	价格	促销价格	库存

18817579266

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18817579266

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实验数据

储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.7950 mL
- 13.9748 mL
- 27.9495 mL
- 5 mM
- 0.5590 mL
- 2.7950 mL
- 5.5899 mL
- 10 mM
- 0.2795 mL
- 1.3975 mL
- 2.7950 mL
计算器摩尔计算器总药量计算器工作液计算器

技术信息

CAS号

53-86-1

储存条件

粉末: -20°C 3 年

液体: -80°C 12 月

分子式

C19H16ClNO4

运输

蓝冰

分子量

357.79

别名

Indocin

溶解度

DMSO	71.0 mg/mL (198.4 mM)
Water	Insoluble
Ethanol	24.0 mg/mL (67.1 mM)

动物实验配方

5% DMSO+30% PEG 300+5% Tween 80+water

2 mg/mL

靶点数据

生物活性

描述Indomethacin is a potent and nonselective inhibitor of COX1 and COX2, with IC50s of 18 nM and 26 nM for human COX-1 and COX-2, respectively, in CHO cells^[3]. Indomethacin disrupts autophagic flux by disturbing the normal functioning of lysosomes and, by doing so, increases the sensitivity of gastric cancer cells to cytotoxic agents, an effect that could be used to overcome cancer cell resistance to antineoplastic regimes^[4]. Concomitant administration of indomethacin (30 mg/kg) and curcumin resulted in a significantly reduced gastric damage compared to indomethacin alone^[5]. Indomethacin treatment (i.p.) modulates microglia activation, contributing to increased neuroblast proliferation in the SVZ (subventricular zone) and migration to the ischaemic striatum following stroke^[6].