Ack1
货号 | 产品名 | CAS号 | 信息 |
---|---|---|---|
FB10075 | XMD8-87 | 1234480-46-6 | XMD8-87 is a tyrosine kinase nonreceptor 2 (TNK2) inhibitor with IC50s of 38 nmol/L and 113 nmol/L for the D163E and R806Q mutations. |
FB10076 | XMD16-5 | 1345098-78-3 | XMD16-5 is an inhibitor of TNK2 with IC50 value of 0.38µM, potently inhibiting phosphorylation of TNK2 truncation mutations found in solid tumor types. |
FB03261 | KRCA-0008 | 1472795-20-2 | KRCA-0008 is a potent and selective ALK/Ack1 inhibitor with IC50 of 12 nM/4 nM for ALK and Ack1 respectively and displays drug-like properties without hERG liability. |
FB01234 | AIM-100 | 873305-35-2 | AIM-100 is a potent and selective Ack1 (TNK2) inhibitor with IC50 value of 22nM, showing suppression phosphorylation of Tyr267 of the androgen receptor in prostate cancer cells. |