AMPAR
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| FB00782 | β-ODAP | 5302-45-4 | β-ODAP is an analog of glutamic acid present in Lathyrus sativus (grass pea) that activates AMPA receptors. |
| FB03932 | ZK200775 | 161605-73-8 | ZK200775 is a highly selective AMPA/kainate antagonist with little activity against NMDA with Ki values of 3.2 nM, 100 nM, and 8.5 μM against quisqualate, kainate, and NMDA, respectively. |
| FB02679 | ZK200775 Hydrate | 1255517-78-2 | ZK200775 is a highly selective AMPA/kainate antagonist with little activity against NMDA and has Ki values of 3.2 nM, 100 nM, and 8.5 μM against quisqualate, kainate, and NMDA, respectively. |
| FB12756 | YM 90K HCl | 154164-30-4 | YM90K hydrochloride is an AMPA receptor antagonist. |
| FB12721 | UBP 282 | 544697-47-4 | UBP-282 is an α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) and kainate receptor antagonist. |
| FB15921 | UBP 310 | 902464-46-4 | UBP 310 is an antagonist of GluK1 (formerly GLUK5) kainate receptor with IC50 of 130 nM. |
| FB15922 | (S)-2-((3-(2-Amino-2-carboxyethyl)-2,6-dioxo-2,3-dihydropyrimidin-1(6H)-yl)methyl)benzoic acid | 745055-91-8 | UBP 302 is a potent and selective GluK1 (formally GluR5)-subunit containing kainate receptor antagonist with KD of 402 nM. |
| FB00184 | Talampanel | 161832-65-1 | Talampanel, a potent and selective AMPA-receptor antagonist, is a potential antiepileptic drug (AED). |
| FB05333 | SYM2206 | 173952-44-8 | SYM2206 is a potent, non-competitive AMPA receptor antagonist (IC50= 2.8 μM). |
| FB11073 | Selurampanel | 912574-69-7 | Selurampanel is a competitive AMPA/kainate receptor antagonist drug for epilepsy. |
| FB00373 | Piracetam | 7491-74-9 | Piracetam is a cyclic derivative of GABA which works as a positive allosteric modulator of the AMPA receptor. |
| FB15611 | Philanthotoxin 74 2HCl | 1227301-51-0 | Philanthotoxin 74 dihydrochloride (PhTx 74) is an AMPAR antagonist; inhibits GluR3 and GluR1 with IC50s of 263 and 296 nM, respectively. |
| FB12073 | PF-4778574 | 1219633-99-4 | PF-4778574 is a positive allosteric modulation of AMPA receptor with EC50 of 45 to 919 nM in differenct cells. |
| FB03180 | PEPA | 141286-78-4 | PEPA is an allosteric modulator of AMPA receptors and binds to the GluA2o and GluA3o LBDs and can be utilized as an indicator of AMPA receptor heterogeneity. |
| FB16766 | PD-161989 | 186268-07-5 | PD-161989 is an AMPA receptor antagonist. |
| FB12499 | NPEC-caged-(S)-AMPA | 1257323-84-4 | NPEC-caged-(S)-AMPA is an agonist at the AMPA receptor. |
| FB09516 | Noopept | 157115-85-0 | Noopept is a potent nootropic that improves cognitive ability. |
| FB11861 | NBQX | 118876-58-7 | NBQX is a potent, selective and competitive AMPAR antagonist, which shows activity of neuroprotective and anticonvulsant. |
| FB12473 | NBQX Disodium Salt | 479347-86-9 | NBQX Disodium Salt is a potent, selective and competitive AMPA receptor antagonist. |
| FB02378 | Naspm | 122306-11-0 | Naspm is a potent and selective Ca2+ permeable AMPA receptor (Ca-perm AMPAR) blocker. |
| FB00408 | Naspm 3HCl | 1049731-36-3 | Naspm 3HCl is a potent and selective Ca2+ permeable AMPA receptor (Ca-perm AMPAR) blocker. |
| FB01586 | LY451395 | 375345-95-2 | LY451395 is a potent and highly selective potentiator of the AMPA receptors. |
| FB08296 | LY450108 | 376594-67-1 | LY450108 is an alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptor potentiator. |
| FB11162 | LY3130481 | 1610802-47-5 | LY3130481 is the the first α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonist that is dependent on the presence of TARP γ-8. LY3130481 is fully protective against pentylenetetrazole-induced convulsions in rats without the motor impairment associated with non-TARP-dependent AMPA receptor antagonists. |
| FB12397 | LY 404187 | 211311-95-4 | LY 404187 is a selective positive allosteric modulator of AMPA receptors with IC50s of 0.15, 0.21, 1.66 and 5.65 μM for GluA2i, GluA4i, GluA3i and GluA1i respectively. |
| FB03374 | Lentinan | 37339-90-5 | Lentinan, a natural product isolated and purified from shiitake mushroom (Lentinus edodes), is an intravenous anti-tumor polysaccharide isolated from the fruit body of shiitake. |
| FB16646 | Lentinan | 37339-90-5 | Lentinan, a natural product isolated and purified from shiitake mushroom (Lentinus edodes), is an intravenous anti-tumor polysaccharide isolated from the fruit body of shiitake. |
| FB03374 | Lentinan | 37339-90-5 | Lentinan, a natural product isolated and purified from shiitake mushroom (Lentinus edodes), is an intravenous anti-tumor polysaccharide isolated from the fruit body of shiitake. |
| FB16646 | Lentinan | 37339-90-5 | Lentinan, a natural product isolated and purified from shiitake mushroom (Lentinus edodes), is an intravenous anti-tumor polysaccharide isolated from the fruit body of shiitake. |
| FB00609 | L-Theanine | 3081-61-6 | L-theanine is an amino acid found most commonly in tea leaves and binds to ionotropic glutamate receptors in the micromolar range, including the AMPA and kainate receptors and, to a lesser extent, the NMDA receptor. |
| FB15551 | JNJ-61432059 | 2035814-50-5 | JNJ-61432059 is an oral active and selective negative modulator of AMPAR associated with trans-membrane AMPAR regulatory protein (TARP) γ-8, with a pIC50 of 9.7 for GluA1/γ-8. Exhibits time- and dose-dependent AMPAR/γ-8 receptor occupancy in mouse hippocampus, resulting in robust seizure protection in corneal kindling and pentylenetetrazole (PTZ) anticonvulsant models[1]. |
| FB12253 | JNJ 55511118 | 2036081-86-2 | JNJ 55511118 is a high affinity and selective negative modulator of AMPA receptors containing TARP-γ8 with Ki of 26 nM. |
| FB16569 | IDRA 21 | 22503-72-6 | IDRA-21 is a positive AMPA receptor modulator. IDRA-21 inhibits synaptic and extrasynaptic NMDA receptor mediated events in cultured cerebellar granule cells. IDRA 21 enhances ischemic hippocampal neuron injury. |
| FB12591 | GYKI 52466 2HCl | 102771-26-6 | GYKI 52466 2HCl is a selective non-competitive AMPA receptor antagonist with IC50 of 10-20 μM. |
| FB08962 | L-Quisqualic Acid | 52809-07-1 | Glutamate receptor agonist acting at AMPA receptors and metabotropic glutamate receptors positively linked to phosphoinositide hydrolysis. Sensitizes neurons in hippocampus to depolarization by L-AP6 (the so called 'quis' effect). |
| FB17966 | Farampator | 211735-76-1 | Farampator (CX-691;Org24448) is an AMPA receptor positive modulator. |
| FB02482 | CX-546 | 215923-54-9 | CX-546 is a AMPAR potentiator which can destabilize the desensitized receptor conformation. |
| FB12577 | CX 614 | 191744-13-5 | CX 614 is a positive allosteric modulator of AMPA receptors. |
| FB09744 | CP 465022 | 199655-36-2 | CP 465022 HCl is a selective, non-competitive AMPA receptor antagonist (IC50 = 25 nM in rat cortical neurons) that displays potent anticonvulsant activity. |
| FB12552 | CNQX | 115066-14-3 | CNQX is a potent and selective non-NMDA iGluR antagonist. |
| FB12204 | CNQX Disodium Salt | 479347-85-8 | CNQX Disodium Salt is a AMPA/kainate antagonist and also available as part of the Kainate Receptor. |
| FB04932 | CMPDA | 380607-77-2 | CMPDA is a positive allosteric modulator of AMPA receptors with EC50s of 45.4 ± 4.2 nM/63.4 ± 5.6 nM for GluA2i/GluA2o receptor. |
| FB08066 | CFM-2 | 178616-26-7 | CFM-2 is a selective non-competitive AMPAR antagonist. |
| FB15930 | ATPA | 140158-50-5 | ATPA is a selective and potent GluK1 kainate receptor agonist with Ki of 4.3 nM. |
| FB16470 | 1-BCP | 34023-62-6 | 1-BCP is can modulate AMPA receptor gated currents and enhence memory. |
| FB09136 | (S)-Willardiine | 21416-43-3 | (S)-Willardiine is a potent agonist of AMPA/kainate receptors with EC50 of 44.8 μM. |
| FB13126 | L-Glutamic Acid | 56-86-0 | (S)-Glutamic acid acts as an excitatory neurotransmitter in the central nervous system. |
| FB12572 | (S)-AMPA | 83643-88-3 | (S)-AMPA is a selective AMPA agonist. |
| FB00578 | (S)-(-)-5-Fluorowillardiine | 140187-23-1 | (S)-(-)-5-Fluorowillardiine is a potent and specific AMPAR agonist. |
| FB02739 | (S)-(-)-5-Fluorowillardiine HCl | 1321546-70-6 | (S)-(-)-5-Fluorowillardiine HCl is a potent and specific AMPAR agonist. |