Ser/Thr Protease
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| FB14518 | ZK824859 | 2271122-53-1 | ZK824859 is a new structural class uPA inhibitor with potential effect on treating multiple sclerosis. |
| FB04803 | UKI-1 | 220355-63-5 | UKI-1 is a synthetic inhibitor of the urokinase-type plasminogen activator system. |
| FB11084 | UK-371804 | 256477-09-5 | UK-371804 is a potent and selective urokinase-type plasmogen activator (uPA) inhibitor with excellent enzyme potency (Ki=10 nM) and selectivity profile (4000-fold versus tPA and 2700-fold versus plasmin). |
| FB12887 | UK-371804 HCl | 256476-36-5 | UK-371804 HCl is a potent and selective urokinase-type plasmogen activator (uPA) inhibitor with excellent enzyme potency (Ki=10 nM) and selectivity profile (4000-fold versus tPA and 2700-fold versus plasmin). |
| FB13136 | NSC95682 | 20035-41-0 | NSC95682 is a derivative of bromobenzaldehyde which can inhibit inositol-requiring enzyme 1 α (IRE-1α) with IC50 of 0.08 μM. |
| FB07134 | Nafamostat Mesylate | 82956-11-4 | Nafamostat mesylate is a synthetic inhibitor of serine protease with anticoagulant activity. |
| FB06295 | Nafamostat | 81525-10-2 | Nafamostat is a broad spectrum serine protease inhibitor, kallikrein inhibitor, and inhibits blood coagulation. It is also a possible complement inhibitor. |
| FB06290 | Nafamostat HCl | 80251-32-7 | Nafamostat HCl is a broad spectrum serine protease inhibitor, kallikrein inhibitor, and inhibits blood coagulation. It is also a possible complement inhibitor. |
| FB11232 | hFD Inhibitor C2 | 1386455-76-0 | hFD inhibitor C2 is an orally bioavailable compound and a highly potent and selective small-molecule reversible Factor D inhibitors demonstrating alternative complement pathway inhibition in vivo. |
| FB11527 | GSK'872 | 1346546-69-7 | GSK'872 is an inhibitor of RIPK3 with IC50 of 1.8 nM and kinase activity (IC50 = 1.3 nM). It also exhibits supression of necrosis induced by toll-like receptor 3. |
| FB11575 | GCN2-IN-1 | 1448693-69-3 | GCN2-IN-1 is a potent general control nonderepressible 2 kinase (GCN2) inhibitor with IC50s of <0.3 μM in the enzyme and cell assay. |
| FB02047 | Gabexate Mesylate | 56974-61-9 | Gabexate mesylate could inhibit trypsin, plasmin, plasma kallikrein and thrombin with IC50s of 9.4 μM, 30 μM, 41 μM and 110 μM. It has certain anticoagulant effect. |
| FB11784 | FK-448 Free base | 85858-76-0 | FK-448 Free base is an effective and specific inhibitor of chymotrypsin, with an IC50 of 720 nM. |
| FB10811 | Factor XIa Inhibitor C9 | N/A | Factor XIa inhibitor C9, an alkyl-substituted macrocyclic amide linker, is a Factor XIa inhibitor with improved oral bioavailability. |
| FB10812 | Factor XIa Inhibitor C18 | 1329162-26-6 | Factor XIa inhibitor C18, an alkyl-substituted macrocyclic amide linker, is a Factor XIa inhibitor with improved oral bioavailability. |
| FB16660 | Benzamidine HCl | 1670-14-0 | Benzamidine hydrochloride is an reversible competitive inhibitor of trypsin-like serine proteases, with Kis of 97 µM, 21 µM, 20 µM and 110 µM for uPA, trypsin, tryptase and factor Xa, respectively. |
| FB07801 | Aprotinin | 9087-70-1 | Aprotinin is an inhibitor of serine protease which can inhibit trypsin and chymotrypsin with Ki values of 0.06 pM and 9 nM. |
| FB12928 | 7H-Purin-2-amine | 452-06-2 | 7H-Purin-2-amine, isomer of adenine, is an inhibitor of protein kinase R (PKR) with antimetabolite effect. |
| FB15494 | 3,4-Dichloroisocoumarin | 51050-59-0 | 3,4 Dichloroisocoumarin is a potent, irreversible inhibitor of serine proteases. It reacts with serine proteases to release an acylchloride moiety that can acylate another active site residue. 3,4 Dichloroisocoumarin also inhibits granzymes A, B, and H, cathepsin G, neutrophil elastase, proteinase and blocks apoptotic internucleosomal DNA cleavage in thymocytes without the involvement of endonucleases. 3,4 Dichloroisocoumarin inhibits activation of neutral sphingomyelinase and daunorubicin-triggered apoptosis as well as apoptosis induced by camptothecin in HL-60 cells. 3,4 Dichloroisocoumarin inhibits migration of eosinophils through basement membrane components in vitro. 3,4 Dichloroisocoumarin does not affect thiol proteases and metalloproteases. 3,4 Dichloroisocoumarin does not exhibit any activity towards β-lactamases. 3,4 Dichloroisocoumarin is an inhibitor of Chymotrypsin and Trypsin. |
| FB20247 | Milvexian | 1802425-99-5 |