PAK
货号 | 产品名 | CAS号 | 信息 |
---|---|---|---|
FB01139 | PF-3758309 | 898044-15-0 | PF-3758309 is an inhbitor of PAKs with IC50 of 1.3 nM for PAK4, which inhbits tumor growth in HCT116, A549, M24met and other xenograft tumor models. |
FB03961 | KPT-9274 | 1643913-93-2 | PAK4-IN-1 is an inhibitor of p21-activated kinases (PAKs), with IC50 of ≤100 nM in MTT assay. |
FB10897 | NVS-PAK1-1 | 1783816-74-9 | NVS-PAK1-1 is a potent allosteric inhibitor of p21-activated kinase PAK1, a serine-threonine kinase that is upregulated in many cancers. NVS-PAK1-1 has an IC50 value of 5 nM for dephoshorylated PAK1 and 6 nM for phosphorylated PAK1 in an in vitro dephosphorylation assay. |
FB16508 | LCH 7749944 | 796888-12-5 | LCH-7749944 is a novel and potent p21-activated kinase 4 (PAK4) inhibitor that suppresses proliferation and invasion in human gastric cancer cells through downregulation of PAK4/c-Src/EGFR/cyclin D1 pathway and causes successful inhibition of EGFR activity. |
FB04949 | IPA-3 | 42521-82-4 | IPA-3 is a selective non-ATP competitive PAK1 inhibitor with IC50 of 2.5 μM, no inhibition to group II PAKs (PAKs 4-6). |
FB03965 | G-5555 | 1648863-90-4 | G-5555 is a selective PAK1 inhibitor (Ki=3.7 nM). |
FB08328 | FRAX597 | 1286739-19-2 | FRAX597, a small-molecule pyridopyrimidinone, is a potent and ATP competitive inhibitor of the group I PAKs (PAK1 IC50= 8 nM, PAK2 IC50= 13 nM, PAK3 IC50= 19 nM). |
FB02389 | FRAX486 | 1232030-35-1 | FRAX486 is a selective inhibitor of group I PAKs with IC50s of 8.25/39.5, /55.3 nM for PAK1/PAK2/PAK3 respectivelt and less potent for PAK4 (IC50=779 nM). |
FB03220 | FRAX1036 | 1432908-05-8 | FRAX-1036 is a potent and selective PAK1 inhibitor. |
FB06938 | APTO-253 | 916151-99-0 | APTO-253 is a small molecule with potent anti-tumor activity in cancer cells via induction of the gene that expresses the Kruppel-like factor 4 (KLF4) master transcription factor, leading to cell cycle inhibition and programmed cell death. |
FB06430 | Alpiniaterpene A | 1448667-05-7 | Alpiniaterpene A is a p21-activated kinase 1 (PAK1) inhibitors isolated from different parts of alpinia zerumbethas has a hair growth promoting and anticancer effects. |