Alkaloids
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| FB05317 | Zanthobungeanine | 64190-94-9 | Zanthobungeanine, a natural product isolated and purified from the roots of Zanthoxylum nitidum with anti-inflammatory activity, shows the inhibitory action on the development of A549 cell only in high concentration and has no antipersonnel effect on A549 cell, moderate NO production inhibitory activity with an IC50 value of 37.26 mg /L, and obviously inhibitoryactivity to platelet aggregation caused by platelet-activating factor (PAF). |
| FB10724 | Tomatidine | 77-59-8 | Tomatidine, a natural product isolated and purified from the fruits of Lycopersicon esculentum Mill., shows antibiotic activity against small-colony variants of S. aureus, significantly suppresses the activity of ACAT and leads to reduction of atherogenesis. It also inhibits the phosphorylation of ERK, Akt, and the nuclear content of NF-κB. |
| FB00115 | Thermopsine | 486-90-8 | Thermopsine has antibacterial activity. |
| FB04474 | Strictosamide | 23141-25-5 | Strictosamide, a natural product isolated and purified from the herbs of Nauclea latifolia, may have important effects on inflammation and inflammatory pain, shows slightly toxicity to Charles River mouse (LD(50)=723.17 mg/kg), producing CNS depression and kidney toxicity, and has nonsignificant in vitro and in vivo effect on kidney Na(+),K(+)-ATPase activity but produced an in vivo increase of Na(+),K(+)-ATPase activity of brain. |
| FB00960 | Sophocarpine Hydrate | 145572-44-7 | Sophocarpine, a natural product isolated and purified from the herb of Sophora alopecuroidos L., with anti-viral, anti-cachectic and anti-inflammatory effects, can alleviate liver fibrosis mainly by inhibiting the TLR4 pathway, it may be a potential chemotherapeutic agent for chronic liver diseases, ameliorate the ischemic injury induced by transient focal cerebral ischemia in rats and that this neuroprotective effect may be related to the anti-ASIC1 channel and anti-apoptotic action of sophocarpine, and also alleviate hepatocyte steatosis and the potential mechanism may be the activated signaling pathway of AMPK. |
| FB00960 | Sophocarpine Hydrate | 145572-44-7 | Sophocarpine, a natural product isolated and purified from the herb of Sophora alopecuroidos L., with anti-viral, anti-cachectic and anti-inflammatory effects, can alleviate liver fibrosis mainly by inhibiting the TLR4 pathway, it may be a potential chemotherapeutic agent for chronic liver diseases, ameliorate the ischemic injury induced by transient focal cerebral ischemia in rats and that this neuroprotective effect may be related to the anti-ASIC1 channel and anti-apoptotic action of sophocarpine, and also alleviate hepatocyte steatosis and the potential mechanism may be the activated signaling pathway of AMPK. |
| FB11434 | Solasurine | 27028-76-8 | Solasurine is isolated from the herbs of solanum nigrum L.. |
| FB09253 | Securinine | 5610-40-2 | Securinine, a natural product isolated and purified from the leaves and twigs of Securinega suffruticosa with antifungal activity, induces apoptosis in human leukemia HL-60 cells, is a promising monocytic differentiation inducing agent for Acute Myeloid Leukemia (AML). |
| FB05623 | Sambutoxin | 160047-56-3 | Sambutoxin, a natural product isolated and purified from the rotted potato tubers, can cause toxic effects in rats, including body weight loss, feed refusal, hemorrhage in the stomach and intestines, and, finally, death when rats were fed diets supplemented with 0.05 and 0.1% sambutoxin. |
| FB00759 | Rocaglamide | 84573-16-0 | Rocaglamide, a naturally occurring product isolated from the herbs of Aglaia odorata Lour, induces apoptosis through the intrinsic death pathway in various human leukemia cell lines and in acute lymphoblastic leukemia, chronic myeloid leukemia and acute myeloid leukemia cells freshly isolated from patients. |
| FB11100 | Pseudouridimycin | 1566586-52-4 | Pseudouridimycin is a natural product that potently and selectively inhibits bacterial RNAP in vitro, inhibits bacterial growth in culture, and clears infection in a mouse model of Streptococcus pyogenes peritonitis. |
| FB11414 | Protostemotinine | 169534-85-4 | Protostemotinine is an alkaloid purified from the roots and rhizomes of stemona sessilifolia (Miq.). |
| FB11489 | Pingpeimine B | 82851-52-3 | Pingpeimine B is a kind of alkaloid compound. |
| FB09395 | Pingpeimine A | 82841-67-6 | Pingpeimine A is a kind of alkaloid compound. |
| FB04288 | Pellitorine | 18836-52-7 | Pellitorine, a natural product isolated and purified from the herbs of Anacyclus pyrethrum, shows cytotoxic, antiprotozoal and potent antiplatelet aggregation activities against HL60 and MCF-7 cell lines. |
| FB10494 | Oxysophoridine | 54809-74-4 | Oxysophoridine is a natural product isolated and purified from the herb of Sophora alopecuroidos L. Oxysophoridine inhibited N-methyl-D-aspartate NR1 mRNA and protein expression in the cerebral cortex of mice with cerebral ischemia/reperfusion injury. |
| FB08193 | Berlambine | 549-21-3 | Oxyberberine is isolated from the methanol extract of A. mexicana. It has been used to study the SW480 human colon cancer cell line. |
| FB11466 | Oxoglaucine | 5574-24-3 | Oxoglaucine exerted immunomodulatory effects in vivo in a dose-dependent manner. |
| FB05059 | Neoechinulin A | 51551-29-2 | Neoechinulin A, a natural product isolated and purified from Aspergillus chevalieri with anti-inflammatory effect against LPS-stimulated RAW264.7 macrophages through inhibition of the NF-κB and p38 MAPK pathways, may block the phosphorylation of mitogen-activated protein kinase (MAPK) molecule p38, apoptosis signal-regulating kinase 1 (ASK-1) and nuclear translocation of nuclear factor-κB (NF-κB) p65 and p50 subunits, and ameliorate rotenone toxicity by activating a cytoprotective machinery that requires ATP and antioxidant/anti-nitration activities. |
| FB11554 | N-(3-Methoxybenzyl)palmitamide | 847361-96-0 | N-(3-Methoxybenzyl)palmitamide, found in lepidium meyenii walp., is a promising inhibitor of fatty acid amide hydrolase (FAAH). It could counteract the toxicity produced by Aβ (25-35). |
| FB04398 | Lycobetaine | 2121-12-2 | Lycobetaine, a phenanthridine alkaloid, is minor constituent from the amaryllidaceae family that has shown tumor inhibitory effects. |
| FB16633 | Isoliensinine | 6817-41-0 | Isoliensinine is a bisbenzylisoquinoline alkaloid extracted from the seed embryo of Nelumbo nucifera, with anti-oxidant and anti-inflammatory and anti-cancer activities. Isoliensinine induces apoptosis in triple-negative human breast cancer cells. |
| FB11436 | Isofebrifugine | 32434-44-9 | Isofebrifugine is isolated from the roots of dichroa febrifuga with antimalarial activity. |
| FB05057 | Gelsevirine | 38990-03-3 | Gelsevirine, a natural product isolated and purified from the herbs of Gelsemium elegans with anxiolytic activity, may be via the agonist action of glycine receptor in the brain, and can significantly inhibit the proliferation of human carcinoma cell line SW480 and MGC80-3 in a dose-dependent manner, the 50% inhibiting concentration(IC50)of gelsevirine on SW480 cells and MGC80-3 cells are 1.41±0.06 mM and 1.22±0.11 mM respectively. |
| FB11462 | Evolitrine | 523-66-0 | Evolitrine is one of the major alkaloids present in sri lankan acronychia pedunculata. |
| FB12968 | (±)-Evodiamine | 518-18-3 | Evodiamine, a naturally occurring indole alkaloid, is one of the main bioactive ingredients of Evodiae fructus. It shows effect on cancer, obesity, nociception, inflammation, cardiovascular diseases, Alzheimer's disease, infectious diseases and thermo-regulative effects. |
| FB05097 | Eriocalyxin B | 84745-95-9 | Eriocalyxin B, a natural product isolated and purified from the herbs of Isodon eriocalyx, is a potent NF-kappaB inhibitor, can inhibit the NF-kappaB transcriptional activity but not that of cAMP response element-binding protein. |
| FB17902 | Edpetiline | 32685-93-1 | Edpetiline is a principal alkaloid from P. eduardi. Edpetiline has significant antiinflammatory effects. |
| FB09324 | Dendrobine | 2115-91-5 | Dendrobine, a natural product isolated and purified from the herb of Dendrobium nobile Lindl., is an antagonist of β-alanine, taurine and of presynaptic inhibition in the frog spinal cord, has antitumor activity,can inhibit the growth of A549 cells through inducing apoptosis, which is partially dependent on mitochondrial-mediated pathway, and possesses antiviral activity against influenza A viruses, including A/FM-1/1/47 (H1N1), A/Puerto Rico/8/34 H274Y (H1N1), and A/Aichi/2/68 (H3N2) with IC50 values of 3.39 ± 0.32, 2.16 ± 0.91, 5.32 ± 1.68 ug/mL, respectively. |
| FB11432 | Demethyleneberberine | 25459-91-0 | Demethyleneberberine (DMB), a component of CPC, is reported to treat alcoholic liver disease as a novel natural mitochondria-targeted antioxidant. |
| FB06612 | Demethoxyfumitremorgin C | 111768-16-2 | Demethoxyfumitremorgin C, a natural metabolite isolated and purified from marine fungus Aspergillus fumigatus, inhibits the proliferation of PC3 human prostate cancer cells via the intrinsic (mitochondrial) and extrinsic pathway, followed by downstream events leading to apoptotic cell death, and could therefore serve as a useful agent to treat human advanced prostate cancer. |
| FB11478 | Deltaline | 6836-11-9 | Deltaline is extracted from roots of aconitum carmichaeli debx. |
| FB06629 | Daurisoline | 70553-76-3 | Daurisoline, a natural product isolated and purified from the roots of Menispermum dauricu with antiarrhythmic effects, exerts a blocking effect on hERG at concentrations below 30 uM, but does not affect the expression and function of the hERG channel. |
| FB06629 | Daurisoline | 70553-76-3 | Daurisoline, a natural product isolated and purified from the roots of Menispermum dauricu with antiarrhythmic effects, exerts a blocking effect on hERG at concentrations below 30 uM, but does not affect the expression and function of the hERG channel. |
| FB04464 | Crebanine | 25127-29-1 | Crebanine, a natural product isolated and purified from the herbs of Stephania yunnanensis, can eonvert BaCl_2-induced arrhythmia into sinus rhythm in rats, decrease the incidence of VF and CA by CaCl_2 in rats and by chloroform in mice, but has no proteetive effects on ouahain-indueed arrhythmias in guinea pigs. |
| FB11461 | Corytuberine | 517-56-6 | Corytuberine is antipsychotic that exerts naloxone-reversible antinociceptive activity. |
| FB07344 | (+)-Corypalmine | 6018-39-9 | Corypalmine is an alkaloid which has been isolated from the crude base fraction of Corydalis chaerophylla and can inhibit prolyl oligopeptidase. |
| FB06699 | Coixol | 532-91-2 | Coixol is a natural product isolated and purifed from the seeds of Coix lacryma-jobi L. |
| FB05150 | Bullatine A | 1354-84-3 | Bullatine A (BLA) is a diterpenoid alkaloid of the genus Aconitum with anti-rheumatic, anti-inflammatory and anti-nociceptive effects. |
| FB05307 | Akuammigine | 642-17-1 | Akuammidine, a natural product isolated and purified from the herbs of Picralima nitida with in vitro antimalarial activity, shows a preference for mu-opioid binding sites with Ki values of 0.6, 2.4 and 8.6 mM at mu-, delta- and kappa-opioid binding sites, respectively and the agonist actions of akuammidine in the mouse-isolated vas deferens were antagonised by naloxone and the mu-opioid receptor selective antagonist D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2 (CTOP) confirming an action at mu-opioid receptors, and competitively antagonizes the effect of noradrenaline on postsynaptic alpha-adrenoceptors, yielding pA2 values of 4.68. |
| FB11419 | 8-Oxycoptisine | 19716-61-1 | 8-Oxycoptisine is purified from the herbs of hypecoum erectum L. with significant antiulcerative colitis efficacy. |
| FB11408 | 6- Methoxydihydrosanguinarine | 151890-26-5 | 6-Methoxydihydrosanguinarine is a benzophenanthridine alkaloid derived from the methanol extracts of Hylomecon hylomeconoides. |
| FB05062 | 5-Hydroxy-4-Methoxycanthin-6-One | 18110-86-6 | 5-Hydroxy-4-methoxycanthin-6-one, a natural product isolated and purified from the barks of Picrasma quassioides (D.Don) Benn with anti-inflammatory effect and protective effect on dextran sulfate sodium -induced rat colitis, exhibits significant cytotoxic activity against CNE2 cell line, reduces the development of carrageenan-induced paw edema and complete Freund's adjuvant (CFA)-induced chronic arthritis in rats. |
| FB07499 | 9-Methoxycamptothecin | 19685-10-0 | 10-Methoxycamptothecin is isolated from the barks of camptotheca acuminata decne which possesses high anti-cancer activity. |
| FB04467 | 1-Hydroxyrutaecarpine | 53600-24-1 | 1-Hydroxyrutaecarpine, a natural product isolated and purified from the fruits of Evodia rutaecarpa (Juss.) Benth., exhibits cytotoxicities (ED50 values < 4 mg/mL) against P-388 or HT-29 cell lines in vitro and antiplatelet activity induced by AA and shows an IC50 value of ca.1-2 mg/mL. |
| FB11422 | (R)-Coclaurine | 2196-60-3 | (R)-Coclaurine is a compound contained in the dried buds of magnolia salicifolia MAXIM. It showed negative inotropic effects. |
| FB11497 | (9Z)-N-[(3-Methoxyphenyl)methyl]-9-octadecenamide | 883715-21-7 | (9Z)-N-[(3-Methoxyphenyl)methyl]-9-octadecenamide has pharmaceutical property against exercise-induced fatigue via by modulating energy metabolism and improving antioxidant status. |
| FB11479 | (-)-Lotusine | 6871-67-6 | (-)-Lotusine is a new cyclopeptide alkaloid from zizyphus lotus with antihypertension and antibacterial activities. |
| FB00023 | (-)-Curine | 436-05-5 | (-)-Curine, an alkaloid isolated from chondrodendron platyphyllum, can inhibit viability of hepatocellular carcinoma cells in regardless of p53 status. |
| FB11443 | (-)-Cephaeline HCl | 3738-70-3 | (-)-Cephaeline HCl, an acidic salt of cephaeline, is an emetic and expectorant. Cephaeline is an alkaloid that is found in cephaelis ipecacuanha and other plant species. |