Secretase
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| FB12116 | β-Secretase Inhibitor IV | 797035-11-1 | β-Secretase Inhibitor IV is a potent, cell-active BACE-1 inhibitor with IC50s of 15.6 and 16.3nM under BACE-1 concentrations of 2 nM and 100 pM, respectively. |
| FB02072 | Z-Ile-Leu-aldehyde | 161710-10-7 | Z-Ile-Leu-aldehyde is a potent gamma-secretase inhibitor and a Notch signaling inhibitor. |
| FB10224 | Verubecestat Trifluoroacetate | 2095432-65-6 | Verubecestat is a potent and selective beta-secretase inhibitor and BACE1 protein inhibitor or Beta-site APP-cleaving enzyme 1 inhibitor with Kis of 2.2 and 0.38 nM for BACE1 and BACE2, respectively. |
| FB09184 | Verubecestat | 1286770-55-5 | Verubecestat is a BACE1 inhibitor. MK-8931 binds significantly to β-secretase. |
| FB00576 | Semagacestat | 425386-60-3 | Semagacestat is an inhibitor of γ-secretase. It inhibits Aβ42, Aβ38, Aβ40 and the Notch signaling with IC50 of 10 nM, 12 nM, 12.1 nM and 14.1 nM. |
| FB08918 | RO4929097 | 847925-91-1 | RO4929097 is an inhibitor of γ secretase, the IC50s of Aβ40 and notch are 14 nM and 5 nM, respectively. |
| FB02709 | PF-3084014 | 1290543-63-3 | PF-3084014 is a reversible inhibitor of γ-secretase with IC50 of 6.2 nM. |
| FB11739 | PF-06751979 | 1818339-66-0 | PF-06751979 is a potent, brain penetrant, β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor with an IC50 of 7.3 nM in BACE1 binding assay. |
| FB15540 | NGP555 | 1304630-27-0 | NGP555 is a γ-secretase modulator. |
| FB15281 | LY900009 | 209984-68-9 | LY900009 is a γ-secretase inhibitor with IC50 value of 10.9−12.1 nM and 14.1 nM for Aβ production and Notch signaling. |
| FB10798 | LY411575 Isomer 3 | 2070009-28-6 | LY411575 isomer 3 is an isomer of LY411575, which is a potent γ-secretase inhibitor with IC50 of 0.078 nM/0.082 nM (membrane/cell-based), also inhibits Notch clevage with withIC50 of 0.39 nM. |
| FB10795 | LY411575 Isomer 2 | 2070009-70-8 | LY411575 isomer 2 is an isomer of LY411575, which is a potent γ-secretase inhibitor with IC50 of 0.078 nM/0.082 nM (membrane/cell-based), also inhibits Notch clevage with with IC50 of 0.39 nM. |
| FB00944 | LY411575 | 209984-57-6 | LY411575 is an inhibitor of γ-secretase with IC50 of 0.078 nM and it can also inhibit Notch clevage (IC50 = 0.39 nM). |
| FB00946 | LY2886721 | 1262036-50-9 | LY2886721 is an BACE inhibitor used for the treatment of Alzheimer's Disease. |
| FB06438 | LY2811376 | 1194044-20-6 | LY2811376 is the first orally available non-peptidic β-secretase (BACE1) inhibitor with IC50 of 239 nM-249 nM, that acts to decrease Aβ secretion with EC50 of 300 nM, and demonstrates to have 10-fold selectivity towards BACE1 over BACE2, and more than 50-fold inhibition over other aspartic proteases including cathepsin D, pepsin, or renin. |
| FB04077 | LY411575 Isomer 1 | 209984-58-7 | LY-411575 isomer 1 is an isomer of LY411575, which is a potent γ-secretase inhibitor with IC50 of 0.078 nM/0.082 nM (membrane/cell-based), also inhibits Notch clevage with with IC50 of 0.39 nM. |
| FB16522 | LY 2886721 hydrochloride | 1262036-49-6 | LY 2886721 hydrochloride is the first oral inhibitor of human β-secretase (BACE-1) with the potential to treat Alzheimer's Disease. |
| FB02621 | L-685,458 | 292632-98-5 | L-685458 is an inhibitor of amyloid β-protein precursor gamma-secretase activity with Ki of 17 nM. |
| FB06975 | gamma-Secretase Modulators | 937812-80-1 | gamma-Secretase modulators is an Amyloid-β production inhibitor, useful for Alzheimer's disease. |
| FB03210 | gamma-Secretase Modulator 3 | 1431697-84-5 | gamma-Secretase modulator 3 is a gamma-secretase modulator. |
| FB02254 | gamma-Secretase Modulator 2 | 1093978-89-2 | gamma-Secretase modulator 2 is a potent and selective γ-secretase modulator for treatment of Alzheimer's disease. |
| FB02305 | gamma-Secretase Modulator 1 | 1172637-87-4 | gamma-Secretase modulator 1 is a gamma-secretase modulator useful for Alzheimer's disease. |
| FB10312 | Epiberberine Chloride | 889665-86-5 | Epiberberine chloride, a natural alkaloid, is a BACE1 inhibitor, which also exhibits inhibition activity on CYP2D6 and aldose reductase, alpha-adrenoceptors, acetylcholinesterase (AChE), butyrylcholinesterase, and b-site amyloid precursor protein cleaving enzyme 1. |
| FB07517 | E-2012 | 870843-42-8 | E 2012 is a potent γ-secretase modulator. |
| FB02462 | YO-01027 | 209984-56-5 | Dibenzazepine is a dipeptidic γ-secretase inhibitor with IC50 of 2.6 nM and 2.9 nM in cell-free assays for APPL and Notch cleavage, respectively. |
| FB01624 | DAPT | 208255-80-5 | DAPT is an inhibitor of γ-secretase and it can reduce the expression of Aβ40 and Aβ42 with IC50 values of 115 nM and 200 nM. |
| FB04200 | CHF5074 | 749269-83-8 | CHF5074 is a γ-secretase modulator, reduces Aβ42 and Aβ40 secretion, with an IC50 of 3.6 and 18.4 μM, respectively. |
| FB20305 | BMS-906024 | 1401066-79-2 | BMS-906024 is a highly potent, selective inhibitor of γ-secretase mediated signaling of Notch1/2/3/4 receptors with IC50 of 1.6/0.7/3.4/2.9 nM, respectively. |
| FB10373 | BMS-299897 | 290315-45-6 | BMS 299897 is an orally active, potent γ-secretase inhibitor (IC50 = 12 nM). |
| FB11849 | BACE1-IN-1 | 1310347-50-2 | BACE1-IN-1 is a potent and highly brain penetrant BACE1 inhibitor with IC50s of 32 and 47 nM for human BACE1 and BACE2, respectively. |
| FB10369 | AZD3839 | 1227163-84-9 | AZD3839 is an inhibitor of BACE1 with IC50 of 23.6 uM. |
| FB01804 | AZD3293 | 1383982-64-6 | AZD3293 is an oral beta-secretase 1 cleaving enzyme (BACE) inhibitor. |
| FB03808 | Avagacestat | 1146699-66-2 | Avagacestat is an inhibitor of γ-secretase Aβ40 and Aβ42 with IC50s of 0.3 nM and 0.27 nM, respectively. |
| FB11239 | 27-Deoxyactein | 264624-38-6 | 27-Deoxyactein, a natural product isolated and purified from Actaea racemosa, has shown stimulation of osteoblast function and inhibits bone resorbing mediators in the treatment of osteoporosis. It is a derivative of actein, a gamma secretase modulators derived from botanicals. It can also protect the pancreatic β-cells against MG-induced cell death. |