DNA Methyltransferase
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| FB01051 | Zebularine | 3690-10-6 | Zebularine is a DNA methylation inhibitor which forms a covalent complex with DNA methyltransferases, it also inhibits cytidinedeaminase with Ki of 2 μM. |
| FB08596 | SGI-1027 | 1020149-73-8 | SGI-1027 is a potent and selective inhibitor of DNA methyltransferase (DNMT) with IC50 of 6, 8, 7.5 μM for DNMT1, DNMT3A, and DNMT3B, respectively. |
| FB09097 | RG108 | 48208-26-0 | RG108 is a DNA methyltransferase inhibitor with IC50 of 115 nM. |
| FB04933 | Glucose-conjugated MGMT Inhibitor | 382607-78-5 | O6BTG-C8-βGlu is a glucose-conjugated MGMT inhibitor with IC50 values of 32 nM in vitro and 10 nM on HeLa S3 cell and the parent compound O6BTG's IC50 is 9 nM (in vitro). |
| FB07131 | N-Acetylprocainamide | 32795-44-1 | N-Acetylprocainamide is the N-acetylated metabolite of Procainamide, and is a Class III antiarrhythmic agent. |
| FB08705 | Lomeguatrib | 192441-08-0 | Lomeguatrib, an inhibitor of DNA repair protein O(6)-methylguanine-DNA methyltransferase (MGMT) with IC50 of 0.009 μM in cell-free extracts from HeLa S3 cells, is a modified guanine base. |
| FB07509 | Decitabine | 2353-33-5 | Decitabine is a potent inhibitor of DNA methyltransferase with IC50 of 438 nM and 4.38 nM in HL-60 and KG1a cells, respectively. |
| FB06162 | DC_517 | 500017-70-9 | DC_517 is a selective non-nucleoside inhibitor of DNA methyltransferase 1 (DNMT1) (IC50 = 1.7 μM). |
| FB06900 | DC_05 | 890643-16-0 | DC_05 is a non-nucleoside DNMT1 inhibitor (IC50=10.3 μM) with low micromolar IC50 values and significant selectivity toward other AdoMet-dependent protein methyltransferases. |
| FB00348 | 6-Thioguanine | 154-42-7 | 6-Thioguanine belongs to the thiopurine family of drugs that also include mercaptopurine and azathioprine, which are examples of antimetabolites, and is a purine analogue of the nucleobase guanine. It was found to inhibit SARS-CoV PLpro. |
| FB16716 | 5−Fluoro−2'−deoxycytidine | 10356-76-0 | 5−Fluoro−2'−deoxycytidine is a DNMT inhibitor which forms covalent links with the cysteine residue in the DNMT active site. |
| FB04588 | 5-Azacytidine | 320-67-2 | 5-Azacytidine is a nucleoside analogue of cytidine that specifically inhibits DNA methylation by trapping DNA methyltransferases. |