The linear ubiquitination assembly complex (LUBAC), consisting of HOIL-1L, HOIP, and Sharpin, has been reported to activate NF-κB-mediated transcription in response to receptor signaling by ligating linear ubiquitin chains to Nemo and Rip1.
货号 | 产品名 | CAS号 | 信息 |
---|---|---|---|
FB18850 | JTP-0819958 | 2470242-33-0 | JTP-0819958 is a selective and covalent LUBAC (Linear Ubiquitin Chain Assembly Complex) inhibitor. |