CAS:71125-38-7Meloxicam

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Meloxicam 美洛昔康 Cat No. FB08867Cas No. 71125-38-7

Synonyms: UH-AC 62XX

Meloxicam is a nonsteroidal anti-inflammatory agent with selectivity for COX2 (IC50 = 11.8 μM) over COX1 (IC50 = 143 μM) in in vitro assays. It shows potent anti-inflammatory, antipyretic, and analgesic effects with low gastrointestinal toxicity.

规格	价格	促销价格	库存

18817579266

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18817579266

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实验数据

储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.8458 mL
- 14.2288 mL
- 28.4575 mL
- 5 mM
- 0.5692 mL
- 2.8458 mL
- 5.6915 mL
- 10 mM
- 0.2846 mL
- 1.4229 mL
- 2.8458 mL
计算器摩尔计算器总药量计算器工作液计算器

技术信息

CAS号

71125-38-7

储存条件

粉末: -20°C 3 年

液体: -80°C 12 月

分子式

C14H13N3O4S2

运输

蓝冰

分子量

351.40

别名

UH-AC 62XX

溶解度

DMSO	29.0 mg/mL (82.5 mM)
Water	Insoluble
Ethanol	Insoluble

动物实验配方

靶点数据

生物活性

描述Meloxicam is a non-steroidal antiinflammatory agent, inhibits COX activity, with IC50s of 0.49 µM and 36.6 µM for COX-2 and COX-1, respectively^[3]. Meloxicam (0.25 µg/mL) decreases CF41.Mg cell migration and invasion, induces decrease in MMP-2 expression, and increases β-catenin phophorylation in CF41.Mg cells, but does not affect the CF41.Mg cell apoptosis. Meloxicam inhibits COX+ tumor cells, but shows no cytotoxicity on CF41.Mg or MDCK cells at 0.25-25 µg/mL. Furthermore, Meloxicam in combination with doxorubicin, has no synergistic effect on CF41.Mg cells^[4]. Meloxicam (10 mg/kg) alone or in combination with rutin significantly decreases paw liking time on 1st day by 55% and 49% compared with the formalin-treated group, respectively, however the combination reduces time non-significantly on 3rd day in mice. Meloxicam alone or in combination with rutin also decreases relative liver weights, reduces MDA contents, induces liver SOD activities, hampers IL-1β content, and significantly reduces the number of positive caspase-3 immunoreactive cells in mice^[5].