COX
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| FB08058 | Zaltoprofen | 74711-43-6 | Zaltoprofen is an inhibitor of COX with IC50s of 1.3 and 0.34 μM for COX-1 and COX-2, respectively, can be used for treatment of arthritis. |
| FB11163 | Vitacoxib | 1374128-90-1 | Vitacoxib is an imidazole derivative and a COX-2 selective inhibitor to be marketed for veterinary use as nonsteroidal anti-inflammatory drugs. |
| FB04201 | Triflusal | 322-79-2 | Triflusal inhibits the production of thromboxane-B2 in platelets irreversibly by acetylating cycloxygenase-1. |
| FB00282 | Tolmetin | 26171-23-3 | Tolmetin is a cyclooxygenase inhibitor used as a non-steroidal anti-inflammatory agent. |
| FB12135 | TFAP | 1011244-68-0 | TFAP is a cell-permeable pyridinyl-benzamide compound that acts as a COX-1-selective inhibitor (IC50 = 0.80 and 210 µM against ovine COX-1 and COX-2, respectively). |
| FB09810 | Tetrahydropalmatine HCl | 6024-85-7 | Tetrahydropalmatine inhibits the LPSinduced production of COX-2 protein and mRNA in a dose-dependent manner. |
| FB16118 | Syringaldehyde | 134-96-3 | Syringaldehyde is an organic compound that occurs naturally in trace amounts. It possesses worthy bioactive properties and is, therefore, used in pharmaceuticals, food, cosmetics, textiles, pulp and paper industries, and even in biological control applications. |
| FB09639 | Suprofen | 40828-46-4 | Suprofen is a COX1/2 inhibitor and a non-steroidal anti-inflammatory drug (NSAID). |
| FB15745 | Sulindac sulfone | 59973-80-7 | Sulindac sulfone inhibited K-ras-dependent COX-2 protein expression, which resulted in a decrease in prostaglandin synthase E2 production. |
| FB09207 | SC-560 | 188817-13-2 | SC-560 is a highly selective cyclooxygenase-1 (COX-1) inhibitor (IC50 values are 0.009 and 6.3 μM for COX-1 and COX-2 respectively). It inhibits COX-1-derived platelet thromboxane B2, gastric PGE2 and dermal PDE2 production and significantly reduces ovarian surface epithelial tumor growth in vivo. |
| FB12437 | SC 236 | 170569-86-5 | SC-236 is an orally active inhibitor of COX-2. SC-236 displays anti-inflammatory properties and potent antimetastatic activity against both experimental metastases and spontaneous metastases arising following primary tumor excision. |
| FB03717 | Sanggenon D | 81422-93-7 | Sanggenon D, a natural product isolated and purified from the root bark of Morus alba L. |
| FB08444 | Rutaecarpine | 84-26-4 | Rutaecarpine, a COX-2 inhibitor, is an indolopyridoquinazolinone alkaloid isolated from Evodia rutaecarpa and related herbs. |
| FB05158 | Rofecoxib | 162011-90-7 | Rofecoxib is a potent inhibitor of the COX2-dependent production of PGE2 in human osteosarcoma cells with IC50 of 26±10 nM and Chinese hamster ovary cells expressing human COX-2 with IC50 of 18±7 nM. |
| FB04231 | Roburic Acid | 6812-81-3 | Roburic acid, a natural product isolated and purified from the roots of Gentiana macrophylla, inhibits COX-1 and COX-2. |
| FB16847 | PTUPB | 1287761-01-6 | PTUPB is a novel dual COX2 and sHE (soluble epoxide hydrolase) inhibitor. Treatment with PTUPB reduced body weight, liver weight, liver triglyceride and cholesterol content, and the expression of lipolytic/lipogenic and lipid uptake related genes (Acc, Cd36, and Cidec) in HFD mice. This made it be a promising potential therapy for liver steatosis associated with obesity. |
| FB15455 | Propacetamol HCl | 66532-86-3 | Propacetamol HCl is the hydrochloride form of Propacetamol, which is a prodrug of paracetamol (acetaminophen) with improved water solubility. Propacetamol is an analgesic drug delivered by IV when oral application of NSAID is not appropriate or contradicted. |
| FB07588 | Pranoprofen | 52549-17-4 | Pranoprofen is a non-steroidal COX inhibitor with anti-inflammatory effects, used in treatment of ophthalmology. |
| FB04856 | Paradol | 27113-22-0 | Paradol is an effective inhibitor of tumor promotion in mouse skin carcinogenesis, binds to cyclooxygenase (COX)-2 active site, it's a pungent phenolic substance isolated and purified from ginger and other Zingiberaceae plants. |
| FB07708 | NPPB | 107254-86-4 | NPPB can act as a blocker of the chloride channel with IC50 of 100 nM-100 µM and inhibitor of cyclooxygenase (IC50 = 8 µM). |
| FB18849 | Nitroaspirin | 175033-36-0 | Nitroaspirin is a direct and irreversible COX-1 inhibitor. |
| FB11582 | Naproxen Etemesil | 385800-16-8 | Naproxen etemesil is a lipophilic, non-acidic, inactive prodrug of naproxen that is hydrolysed to pharmacologically active Naproxen once absorbed. Naproxen is a COX-1 and COX-2 inhibitor with IC50s of 2.2 and 1.3 μg/mL, respectively in cell assay. |
| FB06314 | Mofezolac | 78967-07-4 | Mofezolac is a highly selective COX1 inhibitor that counteracts inflammatory state both in vitro and in vivo models of neuroinflammation. |
| FB17956 | Metyrosine | 672-87-7 | Metyrosine is a selective tyrosine hydroxylase enzyme inhibitor. Metyrosine exerts anti-inflammatory and anti-ulcerative effects. Metyrosine significantly inhibits high COX-2 activity. Metyrosine is a very effective agent for blood pressure control. |
| FB16062 | Meclofenamic acid | 644-62-2 | Meclofenamic acid is a balanced COX-1/COX-2 inhibitor and a non-selective gap junction blocker. |
| FB04618 | Mavacoxib | 170569-88-7 | Mavacoxib is a veterinary drug used to treat pain and inflammation in dogs with degenerative joint disease. It acts as a COX-2 inhibitor. |
| FB08388 | Lumiracoxib | 220991-20-8 | Lumiracoxib is a COX2 selective inhibitor and a non-steroidal anti-inflammatory drug (NSAID), which inhibits COX2 with IC50 and Ki values of 0.14 μM and 0.06 μM and inhibits COX1 with Ki of 3 μM. |
| FB13036 | Loxoprofen Sodium | 80382-23-6 | Loxoprofen Sodium is a non-selective cyclooxygenase inhibitor, a nonsteroidal anti-inflammatory drug (NSAID) working by reducing the synthesis of prostaglandins from arachidonic acid. |
| FB09796 | Ketorolac | 74103-06-3 | Ketorolac, a non-selective COX inhibitor with IC50s of 1.23 μM and 3.50 μM for COX1 and COX2, is a non-steroidal anti-inflammatory drug. |
| FB16866 | KBT-3022 | 101001-34-7 | KBT3022 is a COX inhibitor. |
| FB09249 | Indobufen | 63610-08-2 | Indobufen is a platelet aggregation inhibitor and a reversible cyclooxygenase inhibitor. It has been used in studying the supportive care and prevention of Atrial Fibrillation. |
| FB11241 | Imrecoxib | 395683-14-4 | Imrecoxib is a selective COX-2 inhibitor. |
| FB03449 | Iguratimod | 123663-49-0 | Iguratimod is a selective inhibitor of COX2 (IC50 = 20 μM/7.7 μg/mL) and several inflammatory cytokines including interleukin-1 (IL-1), IL-6, IL-8 and tumour necrosis factor, it's an anti-inflammatory agent. |
| FB16586 | Ibuprofen piconol | 64622-45-3 | Ibuprofen piconol is a non-steroidal, anti-inflammatory (NSAID) agent for the topical relief of primary thermal burns and sunburns. |
| FB16531 | FPL 62064 | 103141-09-9 | FLP 62064 is a potent 5-lipoxygenase (5-LOX) and COX-2 dual inhibitor. FLP 62064 has potently anti-inflammatory activity. |
| FB02303 | FK 3311 | 116686-15-8 | FK 3311 is a selective inhibitor of COX-2 and an antiinflammatory agent. |
| FB20310 | (S)-Flurbiprofen | 51543-39-6 | Esflurbiprofen, also known as BTS-24332; SFPP; TT-063, is a cyclooxygenase (COX) inhibitor indicated for the treatment of osteoarthritis pain and inflammation. |
| FB17694 | CAY10404 | 340267-36-9 | CAY10404 is a potent and highly selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 1 nM. CAY10404 exhibits no inhibition of COX-1 (IC50>500 µM) . CAY10404 is a potent inhibitor of PKB/Akt and MAPK signalling pathways and induces apoptosis in NSCLC cells. CAY10404, a diarylisoxazole, has good analgesic, anti-inflammatory, and anti-cancer activities . |
| FB09621 | Carprofen | 53716-49-7 | Carprofen reduces inflammation by inhibition of COX-2 with IC50 of 30 nM, does not interfere with COX-1 activity. |
| FB04197 | Bromfenac Sodium | 91714-93-1 | Bromfenac Sodium is a nonsteroidal anti-inflammatory drug (NSAID), which has anti-inflammatory activity and may block prostaglandin synthesis by inhibiting cyclooxygenase 1 and 2. |
| FB08223 | beta-Elemonic acid | 28282-25-9 | Beta-elemonic acid is a triterpene isolated from boswellia that exhibits anticancer activity. |
| FB04742 | alpha-Viniferin | 62218-13-7 | alpha-Viniferin, a natural product isolated and purified from the herb of Carex humilis Leyss., a specific, reversible and noncompetitive AChE inhibitor (IC50 = 2.0 mM), exhibits a dose-dependent inhibition on cyclooxygenase activity, where 50% of inhibition (IC50) was shown at a final concentration of about 7 mM, and has anti-inflammatory activity, down-regulating STAT-1-inducible inflammatory genes via inhibiting ERK-mediated STAT-1 activation in IFN-gamma-stimulated macrophages. |
| FB20371 | 4-Methylamino antipyrine | 519-98-2 | 4-Methylamino antipyrine is an active metabolite of Metamizole. Metamizole is a pyrazolone non-steroidal anti-inflammatory drug (NSAID) and inhibits COX. 4-Methylamino antipyrine has analgesic, antipyretic, and relatively weak anti-inflammatory properties. |
| FB17789 | 3,3'-Diiodo-L-thyronine | 4604-41-5 | 3,3'-Diiodo-L-thyronine (3,3'-T2) is an endogenous metabolite of thyroid hormone. 3,3'-Diiodo-L-thyronine significantly enhances COX activity. |
| FB18005 | 2,6-Dichlorodiphenylamine | 15307-93-4 | 2,6-Dichlorodiphenylamine is an analogue of Diclofenac Sodium (HY-15037) and has anti-Candida albicans activity. Diclofenac Sodium is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells. |
| FB00053 | (±)-Sulfinpyrazone | 57-96-5 | (±)-Sulfinpyrazone is one of the most studied platelet COX inhibitors, also a uricosuric agent that competitively inhibits uric acid reabsorption in kidney proximal tubules. |
| FB00723 | (S)-Ketoprofen | 22161-81-5 | (S)-Ketoprofen is a potent inhibitor of COX with IC50 of 1.9 and 27 nM for COX1 and 2 respectively. |
| FB02040 | (S)-(+)-Ibuprofen | 51146-56-6 | (S)-(+)-Ibuprofen, the S-enantiomer of ibuprofen, is capable of inhibiting cyclooxygenase (COX) at clinically relevant concentrations, R(-)-ibuprofen is not a COX inhibitor. S(+)-Ibuprofen prevents neurodegeneration and cognitive decline in APPswe/PS1dE9 through multiple signaling pathways |
| FB00131 | (R)-(-)-Ibuprofen | 51146-57-7 | (R)-(-)-Ibuprofen, the less active enantiomer of ibuprofen, is an inhibitor of COX1 and 2 with IC50 of 13 and 370 μM respectively, it's a nonsteroidal anti-inflammatory. |
| FB04309 | (-)-Epiafzelechin | 24808-04-6 | (-)-Epiafzelechin, a natural product isolated and purified from the herbs of Celastrus orbiculatus with antioxidant activity, exhibits various modes of action in suppressing HSV-2 multiplication, a dose-dependent inhibition on the COX activity with an IC50 value of 15 µM, and significant anti-inflammatory activity on carrageenin-induced mouse paw edema when the compound (100 mg/kg) was orally administrated at 1 h before carrageenin treatment. |