Microtubule/Tubulin
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| FB10883 | Zampanolide | 179730-36-0 | Zampanolide, discovered in a sponge extract, is a microtubule-stabilizing agent in 2009, is a covalent binding secondary metabolite with potent, low nanomolar activity in mammalian cells. Zampanolide was not susceptible to single amino acid mutations at the taxoid site of β-tubulin in human ovarian cancer 1A9 cells, despite evidence that it selectively binds to the taxoid site. |
| FB11019 | WX-132-18B | 1415262-07-5 | WX-132-18B is a microtubule inhibitor, exhibits promising anti-tumor effects. |
| FB00896 | Vinorelbine Ditartrate | 125317-39-7 | Vinorelbine inhibits microtubule assembly by inducing tubulin aggregation into spirals and paracrystals. |
| FB00579 | Leurocristine Sulfate | 2068-78-2 | Vincristine sulfate is an inhibitor of polymerization of microtubules by binding to tubulin with IC50 of 32 μM. |
| FB15340 | Vincristine | 57-22-7 | Vincristine (Leurocristine) is a microtubule-destabilizing agent (MDA). Vincristine (Leurocristine) binds to tubulin and inhibits the formation of microtubules, thereby inhibiting mitosis of the cancer cell. Vincristine (Leurocristine) is used to treat hematologic cancers, such as leukemia and lymphoma, and childhood sarcomas[1][2]. |
| FB10990 | Tubulysin M | 936691-46-2 | Tubulysin M is a myxobacterial product that can function as an antiangiogenic agent in many in vitro assays with anti-microtubule, anti-mitotic, an apoptosis inducer, anticancer, anti-angiogenic, and antiproliferative activity. |
| FB00598 | Tubulysin B | 205304-87-6 | Tubulysin B is a myxobacterial product that can function as an antiangiogenic agent in many in vitro assays with anti-microtubule, anti-mitotic, an apoptosis inducer, anticancer, anti-angiogenic, and antiproliferative activity. |
| FB04821 | Taltobulin Trifluoroacetate | 228266-41-9 | Taltobulin trifluoroacetat is an analogue of hemiasterlin. It is a potent tubulin inhibitor and an ADCs cytotoxin. |
| FB04820 | Taltobulin | 228266-40-8 | Taltobulin is an analogue of hemiasterlin. It is a potent tubulin inhibitor and an ADCs cytotoxin. |
| FB10010 | Taltobulin HCl | N/A | Taltobulin HCl is an cytotoxin, an analogue of hemiasterlin, and a potent tubulin inhibitor. |
| FB10186 | TAI-1 | 1334921-03-7 | TAI-1 is a potent and specific Hec1 inhibitor, which disrupts Hec1-Nek2 protein interaction. |
| FB16754 | T-1101 tosylate | 2250404-95-4 | T-1101 tosylate is a Hec1/Nek2 (Highly expressed in cancer 1 / NIMA-related kinase 2) inhibitor with antitumor activity. T-1101 tosylate is inactive toward normal cells, kinases and hERG. |
| FB17193 | SSE15206 | 1370046-40-4 | SSE15206 is a microtubule depolymerizing agent which inhibits microtubule polymerization both in biochemical and cellular assays by binding to colchicine site in tubulin. It causes aberrant mitosis resulting in G2/M arrest due to incomplete spindle formation. |
| FB11035 | SP-6-27 | 1384170-58-4 | SP-6-27, a microtubule inhibitor, inhibits angiogenesis and induces apoptosis in ovarian cancer cells. |
| FB16632 | Parbendazole | 14255-87-9 | Parbendazole is a potent inhibitor of microtubule assembly, destabilizes tubulin, with an EC50 of 8.79 nM, and exhibits a broad-spectrum anthelmintic activity. |
| FB10621 | Paclitaxel | 33069-62-4 | Paclitaxel is a microtubule polymer stabilizer with IC50 of 0.1 pM in human endothelial cells. |
| FB12430 | MPC 6827 HCl | 917369-31-4 | MPC 6827 HCl is a potent inhibitor of microtubule formation with IC50 of 1.5 - 3.4 nM. |
| FB04067 | MMAD | 203849-91-6 | MMAD, a potent tubulin inhibitor, is a toxin payload in antibody drug conjugate. |
| FB03990 | MMAD HCl | 173441-26-4 | MMAD HCl, a potent tubulin inhibitor, is a toxin payload in antibody drug conjugate. |
| FB06863 | Mc-MMAE | 863971-24-8 | Mc-MMAE is a protective group (maleimidocaproyl)-conjugated MMAE. |
| FB11042 | Maytansinoid DM4 | 796073-69-3 | Maytansinoid DM4 is a tubulin inhibitor, inhibits the assemblyof microtubules by binding to tubulin, with a linker structure can create an antibody-drug conjugate (ADC). |
| FB03852 | Maitansine | 35846-53-8 | Maitansine is a cytotoxic agent. It inhibits the assembly of microtubules by binding to tubulin at the rhizoxin binding site. |
| FB06940 | Lexibulin 2HCl | 917111-49-0 | Lexibulin 2HCl is a potent tubulin polymerisation inhibitor with IC50 of 10-100 nM in cancer cell lines and with potent cytotoxic and vascular disrupting activity in vitro and in vivo. |
| FB16884 | Latrunculin B | 76343-94-7 | Latrunculin B is a toxic inhibitor of actin polymerization. It interacts with G-actin in 1:1 ratio to inhibit polymerization into F-actin in vitro (IC50 values are ~60 and ~900 nM in absence and presence of calf serum, respectively). |
| FB16889 | Latrunculin A | 76343-93-6 | Latrunculin A is a reversible and selective inhibitor of actin assembly. It can block actin adenine nucleotide exchange. |
| FB04093 | Ixabepilone | 219989-84-1 | Ixabepilone is a microtubule inhibitor working by binding to tubulin and promoting tubulin polymerization and microtubule stabilization. |
| FB10185 | INH6 | 1001753-24-7 | INH6 can bind to Hec1 and inhibit its association with Nek2 and kinetochores. |
| FB16358 | Estramustine | 2998-57-4 | Estramustine is an antimicrotubule chemotherapy agent and arrests prostate cancer cells in the G2/M phase of the cell cycle. |
| FB04841 | Eribulin | 253128-41-5 | Eribulin, a synthetic analogue of halichondrin B used for breast cancer, binds to tubulin and microtubules. |
| FB05119 | Eribulin Mesylate | 441045-17-6 | Eribulin mesylate, a synthetic analogue of halichondrin B used for breast cancer, binds to tubulin and microtubules. |
| FB09950 | Epothilone A | 152044-53-6 | Epothilone A is a paclitaxel-like microtubule-stabilizing agent with EC0.01 of 2 μM. |
| FB13153 | Entasobulin | 501921-61-5 | Entasobulin is an inhibitor of β-tubulin polymerization with antineoplastic activity. |
| FB11044 | DM4-SMe | 796073-68-2 | DM4-Me is a tubulin inhibitor, inhibits the assemblyof microtubules by binding to tubulin, with a linker structure can create an antibody-drug conjugate (ADC). |
| FB11043 | DM3-SMe | 796073-70-6 | DM3-SMe is a tubulin inhibitor, inhibits the assemblyof microtubules by binding to tubulin, with a linker structure can create an antibody-drug conjugate (ADC). |
| FB11041 | DM3 | 796073-54-6 | DM3 is a tubulin inhibitor, inhibits the assemblyof microtubules by binding to tubulin, with a linker structure can create an antibody-drug conjugate (ADC). |
| FB10909 | DM1-SMe | 138148-68-2 | DM1-SMe is a tubulin inhibitor, inhibits the assemblyof microtubules by binding to tubulin, with a linker structure can create an antibody-drug conjugate (ADC). |
| FB06271 | D-64131 | 74588-78-6 | D-64131 is a novel tubulin polymerization inhibitor working by competitively binding with colchicine to αβ-tubulin. |
| FB10011 | Cys-mcMMAD | N/A | Cys-mcMMAD, a potent tubulin inhibitor, is a toxin payload in antibody drug conjugate. |
| FB16901 | CHM 1 | 154554-41-3 | CHM-1 induces apoptosis, and it binds tubulin and inhibits tubulin polymerization. CHM-1 possess antimitotic antitumor activity. It is a potent and selective antitumor agent. |
| FB06840 | Cevipabulin | 849550-05-6 | Cevipabulin is a potent, synthetic small molecule, inhibits binding of vinblastine at the Vinca alkaloid site of the αβ-tubulin heterodimer. |
| FB07335 | BTB1 | 86030-08-2 | BTB1 an ATP-competitive and selective inhibitor of the mitotic motor protein Kif18A with IC50 value of 1.7 μM. |
| FB11331 | BRD70326 | 2174006-13-2 | BRD70326 potentiates IL-10 production by suppressing microtubule polmerization. |
| FB06989 | BNC105 | 945771-74-4 | BNC105 is a tubulin polymerization inhibitor with potent antiproliferative and tumor vascular disrupting properties. |
| FB17733 | Batabulin sodium | 195533-98-3 | Batabulin sodium can bind covalently and selectively to a subset of the β-tubulin isotypes, thereby disrupting microtubule polymerization. It affects cell morphology and leads to cell-cycle arrest. |
| FB10060 | Auristatin PE | 149606-27-9 | Auristatin PE is a synthetic Dolastatin 10 derivative and inhibitor oftubulinpolymerization. |
| FB03954 | Auristatin F | 163768-50-1 | Auristatin F is a cytotoxic tubulin modifier with potent and selective antitumor activity, and it is MMAF analog and cytotoxin in antibody-drug conjugates. |
| FB03314 | Auristatin E | 160800-57-7 | Auristatin E is a cytotoxic tubulin modifier with potent and selective antitumor activity and it is an MMAE analog and cytotoxin in Antibody-drug conjugates. |
| FB06233 | Ansamitocin P-3 | 66584-72-3 | Ansamitocin P-3, which is used as an antibody drug conjugate cytotoxin is a maytansine analog which displays potent cytotoxicity against the human solid tumor cell lines A-549 and HT-29. |
| FB11777 | Amphethinile | 91531-98-5 | Amphethinile is an anti-tubulin agent and a novel anti-mitotic agent. The affinity constant for the association (Ka) of Amphethinile with tubulin is 1.3 μM. |
| FB18193 | Myoseverin | 267402-71-1 |