Smo
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| FB11228 | Smo Inhibitor C24 | 1567963-99-8 | Smo inhibitor C24 is a tetrahydropyrido[4,3-d]pyrimidine derivative that represent a set of Smo inhibitors that could potentially be utilized to treat medulloblastoma and other Hh pathway related malignancies. |
| FB01581 | SAG | 912545-86-9 | SAG is a potent Smo receptor agonist, and activates the Hedgehog signaling pathway, with Kd of 59 nM. |
| FB10197 | SAG HCl | 2095432-58-7 | SAG HCl is a cell-permeable Smoothened (Smo) agonist with EC50 of 3 nM in Shh-LIGHT2 cells. |
| FB08814 | Purmorphamine | 483367-10-8 | Purmorphamine is an activator of Smoothened, and blocks BODIPY-cyclopamine binding to Smo with IC50 of appr 1.5 μM and also is an inducer of osteoblast differentiation with EC50 of 1 μM. |
| FB08678 | PF-5274857 | 1373615-35-0 | PF-5274857 is a potent and selective Smoothened (Smo) antagonist, inhibits Hedgehog (Hh) signaling with IC50 and Ki of 5.8 nM and 4.6 nM, respectively, and can penetrate the blood–brain barrier. |
| FB01424 | PF-04449913 | 1095173-27-5 | PF-04449913 is a potent and orally bioavailable smoothened inhibitor. PF-04449913 binds to human SMO (amino acids 181-787) with an IC50 of 4 nM. |
| FB12609 | PF 5274857 HCl | 1613439-62-5 | PF 5274857 HCl is a high affinity and selective Smoothened (Smo) receptor antagonist with Ki of 4.6 nM. |
| FB12506 | PF 04449913 Maleate | 2030410-25-2 | PF 04449913 Maleate is a potent Smo antagonist with IC50 of 5 nM. |
| FB02577 | MK-4101 | 935273-79-3 | MK-4101 inhibits the hedgehog pathway with anti-tumor activity via the inhibition of proliferation and induction of apoptosis. |
| FB00688 | Taladegib | 1258861-20-9 | LY2940680 can bind to the Smo receptor and inhibit hedgehog signaling. |
| FB09423 | LEQ506 | 1204975-42-7 | LEQ506 is an orally bioavailable small-molecule Smoothened (Smo) antagonist with potential antineoplastic activity. |
| FB00705 | LDE225 | 956697-53-3 | LDE225 is an antagonist of Smoothened that can inhibit hedgehog signaling with IC50 of 2.5 nM. |
| FB02371 | LDE225 Diphosphate | 1218778-77-8 | LDE225 diphosphate is a potent and selective Smo antagonist with IC50 of 1.3 nM and 2.5 nM for mouse and human Smo in binding assay, respectively. |
| FB08811 | Jervine | 469-59-0 | Jervine is hedgehog signaling inhibitor with IC50 of 500 nM-700 nM that disrupts the interaction with smoothened. |
| FB12667 | SANT-2 | 329196-48-7 | Inhibitor of Hedgehog (Hh) signaling; antagonizes smoothened activity |
| FB12301 | IHR 1 | 548779-60-8 | IHR 1 is a potent Smo antagonist with IC50 of 7.6 nM. |
| FB12587 | GSA 10 | 300833-95-8 | GSA 10 is a smoothened (Smo) receptor agonist with EC50 of 1.2 μM. |
| FB00083 | Cyclopamine | 4449-51-8 | Cyclopamine is a specific Hedgehog (Hh) signaling pathway antagonist of Smoothened (Smo) with IC50 of 46 nM in TM3Hh12 cells. |
| FB01140 | BMS-833923 | 1059734-66-5 | BMS-833923 is an inhibitor of Smoothened with potential antineoplastic activity. It can also inhibit BODIPY cyclopamine binding to SMO with IC50 of 21 nM. |