NMDAR
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| FB11710 | UK-240455 | 178908-09-3 | UK-240455 is a potent and selective N-methyl D-aspartate (NMDA) glycine site antagonist. |
| FB00481 | Traxoprodil | 134234-12-1 | Traxoprodil a selective antagonist of the NR2B subunit of the NMDA receptor. |
| FB15722 | Traxoprodil mesylate | 189894-57-3 | Traxoprodil a selective antagonist of the NR2B subunit of the NMDA receptor. |
| FB11765 | Transcrocetin Meglumine Salt | N/A | Transcrocetin meglumine salt, extracted from saffron (Crocus sativus L.), acts as an NMDA receptor antagonist with high affinity. |
| FB03190 | Tiletamine HCl | N/A | Tiletamine HCl is an NMDA receptor antagonist used as a dissociative anesthetic. |
| FB09215 | SDZ 220-581 | 174575-17-8 | SDZ 220-581 is a potent, competitive antagonist at the NMDA glutamate receptor subtype (pKi= 7.7). |
| FB04010 | SDZ 220-581 HCl | 179411-93-9 | SDZ 220-581 HCl is a potent, competitive antagonist at the NMDA glutamate receptor subtype (pKi= 7.7). |
| FB04011 | SDZ 220-581 Ammonium | 179411-94-0 | SDZ 220-581 ammonium is a potent, competitive antagonist at the NMDA glutamate receptor subtype (pKi= 7.7). |
| FB07098 | Sarcosine | 107-97-1 | Sarcosine is an NMDAR co-agonist at the glycine binding site. It is an intermediate and byproduct in glycine synthesis and degradation. |
| FB02730 | Ro 25-6981 Maleate | 1312991-76-6 | Ro 25-6981 maleate is a potent and selective activity-dependent blocker of NMDA receptors containing the NR2B subunit. |
| FB09743 | Ro 25-6981 | 169274-78-6 | Ro 25-6981 is a potent and selective activity-dependent blocker of NMDA receptors containing the NR2B subunit. |
| FB02312 | Rapastinel | 117928-94-6 | Rapastinel is a putative NMDAR functional glycine-site partial agonist. |
| FB15284 | Radiprodil | 496054-87-6 | Radiprodil is a selective antagonist of NMDA NR2B that used in treatment of neuropathic pain. |
| FB12904 | Quinolinic acid | 89-00-9 | Quinolinic acid is both a selective agonist at NMDA receptors and also a precursor for the formation of NAD+. |
| FB00719 | QNZ46 | 1237744-13-6 | QNZ46 is a noncompetitive and voltage-independent GluN2C/GluN2D-selective NMDA antagonist with IC50 values of 3, 6, 229 μM for GluN2D, GluN2C, GluN2A, respectively. |
| FB08578 | Procyclidine HCl | 1508-76-5 | Procyclidine HCl is an potent anti-cholinergic agent, and is also known to have NMDA antagonist properties. |
| FB09424 | PEAQX | 459836-30-7 | PEAQX is a potent and orally active NMDA antagonist with a 15-fold preference for human NMDA receptors with the 1A/2A (IC50=270 nM), rather than 1A/2B(29,600 nM). |
| FB10796 | PEAQX Tetrasodium Hydrate | N/A | PEAQX is a potent and orally active NMDA antagonist with a 15-fold preference for human NMDA receptors with the 1A/2A (IC50=270 nM), rather than 1A/2B(29,600 nM). |
| FB10494 | Oxysophoridine | 54809-74-4 | Oxysophoridine is a natural product isolated and purified from the herb of Sophora alopecuroidos L. Oxysophoridine inhibited N-methyl-D-aspartate NR1 mRNA and protein expression in the cerebral cortex of mice with cerebral ischemia/reperfusion injury. |
| FB07902 | Orphenadrine HCl | 341-69-5 | Orphenadrine HCl is an uncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist with Ki of 6.0 ±0.7 μM. |
| FB07901 | Orphenadrine Citrate | 4682-36-4 | Orphenadrine Citrate is both an uncompetitive NMDA receptor antagonist IC50 value of 16.2 µM and a mAChR antagonist with IC50 value of 0.37 µM. |
| FB09425 | NMDA-IN-1 | 700878-19-9 | NMDA-IN-1 is a potent and NR2B-selective NMDA antagonist with Ki of 0.85 nM. Its NR2B Ca2+ influx IC50 is 9.7 nM without activities on NR2A, NR2C, NR2D, hERG-channel and α1-adrenergic receptor. |
| FB09456 | NMDA | 6384-92-5 | NMDA is an amino acid derived specific agonist at the NMDA receptor. |
| FB20328 | L-Cysteinesulfinic acid | 1115-65-7 | NMDA and mGlu agonist. |
| FB04118 | Mephenesin | 59-47-2 | Mephenesin is a centrally acting muscle relaxant which may work as an NMDA receptor antagonist. |
| FB07113 | Memantine | 19982-08-2 | Memantine is the first in a class of Alzheimer's disease medications acting on the glutamatergic system by blocking NMDA receptors. |
| FB08509 | MDL-29951 | 130798-51-5 | MDL-29951 is a glycine antagonist of NMDA receptor activation (Ki=0.14 mM, [3H]glycine binding) in vitro and in vivo. |
| FB02005 | MDL 105519 | 161230-88-2 | MDL 105519 is a potent and selective inhibitor of [3H]glycine binding to the NMDA receptor with Kd of 3.89 nM. |
| FB08208 | Lanicemine | 153322-05-5 | Lanicemine is a low-trapping NMDA receptor antagonist. Lanicemine is used the management of severe and treatment-resistant depression. Lanicemine was originally developed as a neuroprotective agent, but was redeveloped as an antidepressant. |
| FB00656 | L-701,324 | 142326-59-8 | L-701324 is an orally active and long acting anticonvulsant with high affinity and selectivity for the glycine site on the NMDA receptor. |
| FB07266 | Kynurenic Acid Sodium | 2439-02-3 | Kynurenic acid, an endogenous tryptophan metabolite, is a broad-spectrum antagonist targeting NMDA, glutamate, α7 nicotinic acetylcholine receptor. Kynurenic acid is also a selective ligand of the GPR35 receptor. |
| FB02846 | Ifenprodil Tartrate | 23210-58-4 | Ifenprodil Tartrate is a high affinity and atypical noncompetitive NMDA receptor antagonist with IC50 of 0.3 μM. |
| FB02840 | Ibotenic Acid | 2552-55-8 | Ibotenic acid has agonist activity at both the N-methyl-D-aspartate (NMDA) and trans-ACPD or metabolotropic quisqualate (Qm) receptor sites. |
| FB11821 | GNE 5729 | 2026635-66-3 | GNE 5729 is a brain permeable positive allosteric modulator of NMDAR, with an EC50 of 37 nM for GluN2A, 4.7 and 9.5 μM for GluN2C and GluN2D, respectively. |
| FB12015 | GNE 0723 | 1883518-31-7 | GNE 0723 is a brain permeable positive allosteric modulator of NMDAR, with an EC50 of 21 nM for GluN2A, 7.4 and 6.2 μM for GluN2C and GluN2D, respectively. |
| FB01736 | Felbamate | 25451-15-4 | Felbamate is a potent nonsedative anticonvulsant whose clinical effect may be related to the inhibition of N-methyl-D-aspartate (NMDA) . |
| FB02311 | Felbamate Hydrate | 1177501-39-1 | Felbamate is a potent nonsedative anticonvulsant whose clinical effect may be related to the inhibition of N-methyl-D-aspartate (NMDA) . |
| FB07536 | Eliprodil | 119431-25-3 | Eliprodil can antogonize GluN2B-selective NMDA in a non-competitive manner with IC50 value of 1 μM. It is also a σ1 ligand with Ki value of 0.013 μM. |
| FB00202 | D-AP5 | 79055-68-8 | D-AP5 is an antagonist of NMDA receptor (N-methyl-D-aspartate receptor). |
| FB06155 | CIQ | 486427-17-2 | CIQ is a subunit-selective potentiator of NMDA receptors containing the NR2C or NR2D subunit. |
| FB07254 | CGP 37849 | 127910-31-0 | CGP 37849 is a potent, selective and competitive NMDA receptor antagonist (Ki = 35 nM). |
| FB08851 | Budipine | 57982-78-2 | Budipine is an uncompetitive NMDAR antagonist used as an antiparkinson agent. |
| FB11961 | Apimostinel | 1421866-48-9 | Apimostinel is an oral NMDA receptor partial agonist. |
| FB16085 | 6-Methoxy-2-naphthoic acid | 2471-70-7 | 6-Methoxy-2-naphthoic acid is an modulator of NMDAR. |
| FB16651 | ACBC | 22264-50-2 | 1-Aminocyclobutanecarboxylic acid is a NMDA receptor partial agonist acting at the glycine site, NR1. |
| FB13126 | L-Glutamic Acid | 56-86-0 | (S)-Glutamic acid acts as an excitatory neurotransmitter in the central nervous system. |
| FB16254 | (R)-Serine | 312-84-5 | (R)-Serine is the R-enantiomer of serine, which is used in the biosynthesis of proteins. |
| FB02373 | (-)-MK 801 Maleate | 121917-57-5 | (-)-MK 801 maleate is the enantiomer of (+)-MK-801, which is a highly potent and selective non-competitive NMDA glutamate receptor antagonist . |
| FB16648 | (-)-Aspartic acid | 1783-96-6 | (-)-Aspartic acid is an endogenous NMDA receptor agonist. |
| FB01468 | (+)-MK 801 Maleate | 77086-22-7 | (+)-MK 801 Maleate is a highly potent, selective and non-competitive NMDA receptor antagonist with Ki of 30.5 nM. |