Transforming Growth Factor beta (TGFβ) Receptor
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| FB04230 | SD-208 | 627536-09-8 | SD-208 is a potent, orally active ATP-competitive transforming growth factor-β receptor 1 (TGF-βRI) inhibitor (IC50= 49 nM) and displays > 100-fold and > 17-fold selectivity over TGF-βRII and other common kinases respectively. |
| FB07085 | SB-505124 | 694433-59-5 | SB505124 is an inhibitor of TGFβ receptor for ALK4 (IC50 = 129 nM) and ALK5 (IC50 = 47 nM). It can also inhibit ALK7. |
| FB09206 | SB-431542 | 301836-41-9 | SB431542 is a potent and selective inhibitor of ALK5 with IC50 of 94 nM, 100-fold selective for ALK5 than p38 MAPK and other kinases. |
| FB06654 | SB-525334 | 356559-20-1 | SB-525334 is a potent and selective inhibitor of TGFβ receptor I (ALK5) with IC50 of 14.3 nM, is 4-fold less potent to ALK4 than ALK5 and inactive to ALK2, 3, and 6. |
| FB06308 | SB-505124 HCl | 356559-13-2 | SB-505124 HCl is a selective inhibitor of TGFβR for ALK4, ALK5 with IC50 of 129 nM and 47 nM, respectively, also inhibits ALK7, but does not inhibit ALK1, 2, 3, or 6. |
| FB01814 | RepSox | 446859-33-2 | RepSox is a potent and selective inhibitor of the TGFβR-1/ALK5 with IC50 of 23 nM and 4 nM for ATP binding to ALK5 and ALK5 autophosphorylation, respectively. |
| FB06890 | R268712 | 879487-87-3 | R268712 is a potent and selective inhibitor of ALK5 with an IC50 of 2.5 nM. |
| FB08343 | ML347 | 1062368-49-3 | ML347 is a highly selective ALK1/ALK2 inhibitor with IC50s of 46/32 nM and shows > 300-fold selectivity for ALK2 vs. ALK3. |
| FB03753 | LY364947 | 396129-53-6 | LY364947 is a potent ATP-competitive inhibitor of TGFβR-I with IC50 of 59 nM, exhibits 7-fold selectivity over TGFβR-II. |
| FB07653 | LY2157299 | 700874-72-2 | LY2157299 is a potent TGFβ receptor I (TβRI) inhibitor with IC50 of 56 nM in a cell-free assay. |
| FB07318 | LY2109761 | 700874-71-1 | LY2109761 is a selective TGF-β receptor type I/II (TβRI/II) dual inhibitor with Ki of 38 nM and 300 nM, respectively and is shown to negatively affect the phosphorylation of Smad2. |
| FB01426 | LDN-214117 | 1627503-67-6 | LDN-214117 is a potent and selective ALK2 inhibitor with IC50 of 22 nM with > 100 fold selectivity for ALK5, and also inhibits BMP6 (IC50=100 nM). |
| FB03219 | LDN-212854 | 1432597-26-6 | LDN-212854 is an inhibitor of BMP and can inhibit ALK2 with IC50 of 1.3 nM. It is used to prevent heterotopic ossification. |
| FB01047 | LDN-193189 | 1062368-24-4 | LDN-193189 is a selective BMP signaling inhibitor, inhibits the transcriptional activity of the BMP type I receptors ALK2 and ALK3 with IC50 of 5 nM and 30 nM, respectively, exhibits 200-fold selectivity for BMP versus TGF-β. |
| FB01048 | LDN-193189 HCl | 1062368-62-0 | LDN-193189 HCl is a selective BMP signaling inhibitor, inhibits the transcriptional activity of the BMP type I receptors ALK2 and ALK3 with IC50 of 5 nM and 30 nM, respectively, exhibits 200-fold selectivity for BMP versus TGF-β. |
| FB12124 | LDN-193189 2HCl | 1435934-00-1 | LDN-193189 2HCl is a potent and selective ALK2 and ALK3 inhibitor. |
| FB08689 | K02288 | 1431985-92-0 | K02288 is an inhibitor of type I BMP receptor. It targeting ALK2, ALK1 and ALK6 with IC50 of 1.1, 1.8, 6.4 nM, respectively. |
| FB03053 | GW788388 | 452342-67-5 | GW788388 is a selective ALK5 inhibitor with IC50 of 18 nM and also inhibits TGF-β type II receptor and activin type II receptor. |
| FB08676 | EW 7197 | 1352608-82-2 | EW-7197 is a selective inhibitor of TGF-β receptor ALK4 and ALK5 with IC50s of 13 nM and 11 nM. |
| FB11847 | EW-7197 HCl | 1352610-25-3 | EW-7197 HCl is a small-molecule ATP-competitive inhibitor of TGFβRI (ALK5) with an IC50 of 12.9 nM. |
| FB02352 | DMH-1 | 1206711-16-1 | DMH-1 is a potent and selective BMP inhibitor with IC50s of 27/107.9/< 5 nM for ALK1/2/3 respectively and inactive on ALK5, BMPR2, AMPK and VEGFR2. |
| FB08067 | A 77-01 | 607737-87-1 | A77-01 is a potent inhibitor of TGF-β type I receptor superfamily activin-like kinase ALK5 with IC50 of 25 nM. |
| FB15714 | A 83-01 Sodium Salt | N/A | A 83-01 Sodium Salt is a selective inhibitor of TGF-β type I receptor ALK5 kinase, type I activin/nodal receptor ALK4 and type I nodal receptor ALK7, with IC50 values of 12, 45 and 7.5 nM, respectively. |
| FB01883 | A 83-01 | 909910-43-6 | A 83-01 is a selective inhibitor of TGF-β type I receptor ALK5 kinase, type I activin/nodal receptor ALK4 and type I nodal receptor ALK7, with IC50 values of 12, 45 and 7.5 nM, respectively. |