LTR
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| FB08769 | Zafirlukast | 107753-78-6 | Zafirlukast is the first-approved LTR antagonist with anti-asthmatic and potential capsular contracture-preventing activities. |
| FB03777 | KCA 757 | 125961-82-2 | Tipelukast (KCA 757) is a sulfidopeptide leukotriene receptor antagonist, an orally bioavailable anti-inflammatory agent and used for the treatment of asthma. |
| FB09006 | Rev 5901 | 101910-24-1 | Rev-5901 is an antagonist of cysteinyl-leukotriene receptors with a Ki value of 0.7 µM for guinea pig lung membranes. It is also an inhibitor of rat neutrophil 5-LO with an IC50 value of 0.12 µM. |
| FB08528 | Pranlukast | 103177-37-3 | Pranlukast is a selective CysLt1 leukotriene receptor antagonist. |
| FB05954 | Montelukast Sodium | 151767-02-1 | Montelukast Sodium is a potent, selective and competitive LTR1 antagonist with IC50 value < 5 nM, possesssing anti-inflammatory and bronchodilating activities. |
| FB08387 | MK-571 Sodium | 115103-85-0 | MK-571 Sodium is a competitive, potent and selective LTD4 antagonist with Ki values of 0.22 nM. |
| FB19889 | LY293111 | 161172-51-6 | LY293111 is a potent LTB4 receptor antagonist with IC50 values of 17.6nM and 6.3nM for inhibition of the specific binding of radiolabeled-LTB4 to isolated human neutrophils and the LTB4-induced chemotaxis of human neutrophils, respectively. |
| FB07704 | LY255283 | 117690-79-6 | LY255283 is selective, competitive antagonist of BLT2 receptors (IC50 values are ~ 1 and > 10 μM at human recombinant BLT2 and BLT1 receptors respectively), and inhibits LTB4-induced contraction of lung parenchyma (pA2 = 7.2), and reduces LTB4-mediated airway obstruction in guinea pigs following i.v. and oral administration. |
| FB18829 | Leukotriene B4 | 71160-24-2 | Leukotriene B4 is a dihydroxy fatty acid derived from arachidonic acid. It promotes a number of leukocyte functions including aggregation, stimulation of ion fluxes, enhancement of lysosomal enzyme release, superoxide anion production, chemotaxis, and chemokinesis. |
| FB12030 | Iralukast | 151581-24-7 | Iralukast is a cysteinyl-leukotriene antagonist (CysLT) with a pKi of 7.8 for CysLT1. |
| FB11805 | DW-1350 | 491577-61-8 | DW-1350 is a LTB4 receptor antagonist. |
| FB01758 | Cromolyn | 16110-51-3 | Cromoglicic acid is used to treat the symptoms of asthma. |
| FB11626 | CP-96486 | 139401-45-9 | CP-96486 is a potent and orally active leukotriene D4 (LTD4)/platelet activating factor (PAF) receptor antagonist with Kis of 20 and 24 nM, respectively. |