HSP
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| FB18290 | YUM70 | 423145-35-1 | YUM70 is a GRP78 inhibitor with IC50 value of 1.5μM and resulted in ER stress-mediated apoptosis. It inhibited pancreatic cancer cell growth in vitro and showed in vivo efficacy in a pancreatic cancer xenograft model with no toxicity to normal tissues. |
| FB02541 | XL888 | 1149705-71-4 | XL888 is a specific and ATP-competitive Hsp90 inhibitor with IC50 of 24 nM. |
| FB00543 | VER-50589 | 747413-08-7 | VER-50589 is an isoxazole compound that inhibits Hsp90 with an IC50 value of 21 nM. |
| FB06192 | VER-49009 | 558640-51-0 | VER-49009 is a pyrazole compound that inhibits Hsp90 with an IC50 value of 47 nM. |
| FB02456 | VER-155008 | 1134156-31-2 | VER-155008 is a potent Hsp70 family inhibitor with IC50 of 0.5 μM, 2.6 μM, and 2.6 μM in cell-free assays for HSP70, HSC70, and GRP78, respectively, > 100-fold selectivity over HSP90. |
| FB11256 | TRC051384 HCl | 1333327-56-2 | TRC051384 is an inducer of heat shock protein Hsp70. it reduces stroke-associated neuronal injury and increases survival in a rat model of transient ischemic stroke and activates heat shock factor-1 and results in elevated chaperone and anti-inflammatory activity. |
| FB11257 | TRC051384 | 867164-40-7 | TRC051384 is a inducer of Hsp70. |
| FB09694 | Teprenone | 6809-52-5 | Teprenone is used as an anti-ulcer drug, a cardioprotective agent, a hepatoprotective agent, a nephroprotective agent, a neuroprotective agent and a Hsp70 inducer. |
| FB11852 | TAS-116 | 1260533-36-5 | TAS-116 is a potent and selective HSP90α/β inhibitor with Kis of 34.7 nM, 21.3 nM, respectively. |
| FB00033 | SNX-2112 | 908112-43-6 | SNX-2112 is a potent synthetic heat shock protein 90 (HSP90) inhibitor with an IC50 of 0.92 μM for K562 cells. |
| FB06852 | Retaspimycin | 857402-23-4 | Retaspimycin is a small-molecule inhibitor of heat shock protein 90 (HSP90) with antiproliferative and antineoplastic activities. |
| FB06853 | Retaspimycin HCl | 857402-63-2 | Retaspimycin HCl is the HCl salt of a small-molecule inhibitor of heat shock protein 90 (HSP90) with antiproliferative and antineoplastic activities. |
| FB08076 | PU-WS13 | 1454619-14-7 | PU-WS13 is a potent, Grp94-specific Hsp90 inhibitor of the purine scaffold class. |
| FB08930 | PU-H 71 | 873436-91-0 | PU-H71 is a potent Hsp90 inhibitor with IC50 of 50 nM. |
| FB10251 | PU-H 71 HCl | 2095432-24-7 | PU-H71 HCl is a potent Hsp90 inhibitor with IC50 of 50 nM. |
| FB02306 | PF-04929113 Mesylate | 1173111-67-5 | PF-04929113 mesylate is a potent and selective Hsp90 inhibitor with an IC50 of median 50 nM. |
| FB06778 | PF-04929113 | 908115-27-5 | PF-04929113 is a potent and selective HSP90 inhibitor with Kd of 41 nM and induces Her-2 degradation with IC50 of 37 nM. |
| FB08415 | HSP990 | 934343-74-5 | NVP-HSP990 is a potent and selective HSP90 inhibitor for HSP90α/β with IC50 of 0.6 nM/0.8 nM. |
| FB01392 | NVP-BEP800 | 847559-80-2 | NVP-BEP800 is a fully synthetic HSP90β inhibitor with IC50 of 58 nM, exhibits> 70-fold selectivity against Hsp90 family members Grp94 and Trap-1. |
| FB08591 | NMS-E973 | 1253584-84-7 | NMS-E973 is a potent and selective Hsp90 inhibitor with DC50 of < 10 nM for Hsp90 binding, no activiy against a panel of 52 diverse protein kinases. |
| FB01919 | ML346 | 100872-83-1 | ML346 is an activator of Hsp70 with EC50 of 4600 nM in HeLa cell toxicity assay. |
| FB11375 | MKT-077 | 147366-41-4 | MKT-077 (FJ-776) is a water-soluble rhodacyanine dye with antitumor activity. It can bind to Hsp70 family member mortalin-2 and inhibit its interactions with p53. |
| FB12428 | Macbecin I | 73341-72-7 | Macbecin I is a Hsp90 inhibitor with IC50 of 2 μM. |
| FB01613 | KW-2478 | 819812-04-9 | KW-2478 is a nonansamycin HSP90 inhibitor with IC50 of 3.8 nM. |
| FB10250 | KRIBB11 | 342639-96-7 | KRIBB11 is an inhibitor of heat shock factor (HSF) inhibitor, with IC50 of 1.2 μM. |
| FB03390 | KNK437 | 218924-25-5 | KNK437 is a pan-HSP inhibitor, which inhibits the synthesis of inducible HSPs, including HSP105, HSP72, and HSP40. |
| FB16043 | Grp94 Inhibitor-1 | 2234897-35-7 | Grp94 Inhibitor-1 is a potent, selective Grp94 inhibitor with an IC50 value of 2 nM, and over 1000-fold selectivity to Grp94 against Hsp90α[1]. |
| FB02079 | Geldanamycin | 30562-34-6 | Geldanamycin is a natural existing HSP90 inhibitor with Kd of 1.2 μM. |
| FB12249 | Gedunin | 2753-30-2 | Gedunin is a Hsp90 inhibitor and exhibits anticancer and antimalarial activity. |
| FB07756 | Ganetespib | 888216-25-9 | Ganetespib is a unique triazolone-containing Hsp90 inhibitor with an IC50 of 4 nM in OSA 8 cells. |
| FB09039 | Eupalinolide B | 877822-41-8 | Eupalinolide A is a natural product isolated and purified from the herbs of Eupatorium lindleyanum DC. |
| FB16588 | Ethoxyquin | 91-53-2 | Ethoxyquin is an antioxidant which has been used in animal feed for many years and also an inhibitor of heat shock protein 90 (Hsp90). |
| FB02528 | Elesclomol | 488832-69-5 | Elesclomol, an inhibitor of HSP90, is a potent oxidative stress inducer that elicits pro-apoptosis events among tumor cells. |
| FB12580 | EC 144 | 911397-80-3 | EC 144 is a high affinity, potent and selective Hsp90 inhibitor with Ki of 0.2 nM and IC50 of 1.1 nM. |
| FB10252 | Debio 0932 | 1061318-81-7 | Debio 0932 is a heat shock protein 90 (HSP90) inhibitor with strong affinity for HSP90 alpha/beta, high oral bioavailability and potent anti-proliferative activity against a broad range of cancer cell lines (with a mean IC50 of 220 nmol/L). |
| FB17550 | Col003 | 328565-16-8 | Col003 is a cell penetrant, selective and potent inhibitor of the interaction of Hsp47 with collagen. Col003 is the cleavage product of AK778.It competitively inhibited the interaction and caused the inhibition of collagen secretion by destabilizing the collagen triple helix. |
| FB10177 | CH5138303 | 959763-06-5 | CH5138303 is an orally available Hsp90 inhibitor with Kd of 0.48 nM. |
| FB12178 | CCT 018159 | 171009-07-7 | CCT 018159 is a novel inhibitor of heat shock protein 90 (Hsp90) ATPase activity with IC50 of 5.7 μM. |
| FB06750 | BIIB021 | 848695-25-0 | BIIB021 is an orally available, fully synthetic small-molecule inhibitor of HSP90 with Ki and EC50 of 1.7 nM and 38 nM, respectively. |
| FB05358 | Luminespib | 747412-49-3 | AUY922 is a highly potent HSP90 inhibitor for HSP90α/β with IC50 of 13 nM /21 nM, weaker potency against the HSP90 family members GRP94 and TRAP-1. |
| FB01492 | Onalespib | 912999-49-6 | AT13387 is a selective potent Hsp90 inhibitor with IC50 of 18 nM in A375 cells, displays a long duration of anti-tumor activity. |
| FB10249 | Apoptozole | 1054543-47-3 | Apoptozole is an inhibitor of heat shock protein 70 (HSP70) and Hsc70. It induces caspase-dependent apoptosis. |
| FB07124 | Alvespimycin | 467214-20-6 | Alvespimycin is a potent, water-soluble HSP90 inhibitor with IC50 of 62 nM. |
| FB05128 | Alvespimycin HCl | 467214-21-7 | Alvespimycin HCl is a potent, water-soluble HSP90 inhibitor with IC50 of 62 nM. |
| FB02224 | 17-AAG | 75747-14-7 | 17-AAG is a potent HSP90 inhibitor with IC50 of 5 nM, having a 100-fold higher binding affinity for HSP90 derived from tumour cells than HSP90 from normal cells. |
| FB06930 | 17-AAG HCl | 911710-03-7 | 17-AAG HCl is a potent HSP90 inhibitor with IC50 of 5 nM, having a 100-fold higher binding affinity for HSP90 derived from tumour cells than HSP90 from normal cells. |