NLR
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| FB10081 | NOD-IN-1 | 132819-92-2 | NOD-IN-1 is a potent mixed inhibitor of nucleotide-binding oligomerization domain (NOD)-like receptors, NOD1 and NOD2, with IC50 of 5.74 μM and 6.45 μM, respectively. |
| FB00032 | ML130 | 799264-47-4 | ML130 is a selective and potent NOD1 inhibitor with IC50 of 560 nM. It inhibits NOD1-induced NF-κB activation. |
| FB04844 | MCC950 Sodium | 256373-96-3 | MCC950 Sodium is a potent and highly specific small molecule inhibitor of NLRP3 inflammasome with IC50 of 7.5 nM in BMDMs. |
| FB04080 | MCC950 | 210826-40-7 | MCC950 is a potent, selective, small-molecule inhibitor of NLRP3 with IC50 of 7.5 nM in BMDMs. |
| FB11723 | INF39 | 866028-26-4 | INF39 is an irreversible NLRP3 inhibitor with IC50 value of ~100 μM for inhibiton of NLRP3 ATPase, which can inhibit IL-1β release, caspase activation and pyroptosis in THP-1 cells. |
| FB18031 | GSK717 | 1595278-21-9 | GSK717 is a potent, selective NOD2 (nucleotide-binding oligomerization domain 2) inhibitor. GSK717 inhibits muramyl dipeptide (MDP)-induced NOD2-mediated signaling, with an IC50 of 400 nM for MDP-stimulated IL-8 secretion in HEK293/hNOD2 cells . |
| FB11615 | CY-09 | 1073612-91-5 | CY-09 can inhibit NLRP3 with Kd value of 500 nM through directly bounding to the ATP-binding site of the NLRP3 NACHT domain. |
| FB16341 | Chalcone, 2′,4′-dihydroxy-6′-methoxy- | 18956-16-6 | Cardamonin (Cardamomin), a natural flavone isolated from Alpinia katsumadai Hayata, acts as an aryl hydrocarbon receptor (AhR) activator. Cardamonin alleviates inflammatory bowel disease by the inhibition of NLRP3 inflammasome activation via an AhR/Nrf2/NQO1 pathway . |