Sodium Channel
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| FB02900 | XEN907 | 912656-34-9 | XEN907 is a spirooxindole NaV1.7 blocker, inhibits hNaV1.7 with IC50 of 3 nM. |
| FB00660 | Tetracaine | 94-24-6 | Tetracaine can interfer the entry of sodium ions into nerve cells and used as a topical local anesthetic. |
| FB16510 | Tenapanor | 1234423-95-0 | Tenapanor is an inhibitor of the sodium-proton (Na(+)/H(+)) exchanger NHE3, which plays a prominent role in sodium handling in the gastrointestinal tract and kidney, with IC50 values of 5 and 10 nM against human and rat NHE3, respectively. |
| FB02896 | Sodium Channel Inhibitor 1 | 1198117-23-5 | Sodium Channel inhibitor1, one of 3-Oxoisoindoline-1-carboxamides, is a selective voltage-gated sodium channel for pain treatment. |
| FB11799 | Sodium Channel Inhibitor 2 | 653573-60-5 | Sodium Channel inhibitor 2 is a sodium channel blocker extracted from patent WO 2004011439 A2, compound 3c. |
| FB12777 | Zoniporide 2HCl | 241799-10-0 | Selective NHE1 inhibitor |
| FB17950 | Ropivacaine mesylate | 854056-07-8 | Ropivacaine mesylate is a long-acting amide local anaesthetic agent for a spinal block and effectively blocks neuropathic pain. Ropivacaine blocks impulse conduction via reversible inhibition of sodium ion influx in nerve fibressup>. Ropivacaine is also an inhibitor of K2P (two-pore domain potassium channel) TREK-1 with an IC50 of 402.7 μM in COS-7 cell's membrane. |
| FB17823 | Ropivacaine | 84057-95-4 | Ropivacaine is a potent sodium channel blocker and blocks impulse conduction via reversible inhibition of sodium ion influx in nerve fibrese. Ropivacaine is also an inhibitor of K2P (two-pore domain potassium channel) TREK-1 with an IC50 of 402.7 μM in COS-7 cell's membrane. Ropivacaine is a local anesthetic agent widely used for regional anesthesia and neuropathic pain management in vivo. |
| FB15672 | Rimeporide | 187870-78-6 | Rimeporide is a potent and selective NHE1 inhibitor. |
| FB16814 | Ralfinamide | 133865-88-0 | Ralfinamide (FCE-26742A) is an orally available Na+ blocker derived from α-aminoamide, with function of suppressing pain . |
| FB02244 | Quinidine Sulfate | 6591-63-5 | Quinidine can act as a voltage-gated sodium channels blocker and an inhibitor of the cytochrome P450 enzymes 2D6/3A4. It is an antimuscarinic and antimalarial. |
| FB09857 | Proparacaine HCl | 5875-06-9 | Proparacaine HCl is an antagonist of voltage-gated sodium channels with ED50 of 3.4 mM. |
| FB09738 | Prilocaine | 721-50-6 | Prilocaine is a local anesthetic of the amino amide type. |
| FB09248 | Phenytoin Sodium | 630-93-3 | Phenytoin sodium is a stabilizer of inactive voltage-gated sodium channel. |
| FB06903 | PH-064 | 892546-37-1 | PH-064 is a sodium channel inhibitor. It is also a selective Gαq inhibitor. It traps Gαq in the empty pocket conformation by permitting GDP exit but interdicting GTP entry. |
| FB11753 | PF-06869206 | 2227425-05-8 | PF-06869206 is an orally bioavailable selective inhibitor of the sodium-phosphate cotransporter NaPi2a (SLC34A1) with an IC50 of 380 nM. |
| FB17253 | PF-06305591 | 1449473-97-5 | PF-06305591 is a potent and highly selective voltage gated sodium channel NaV1.8 blocker, with IC50 of 15 nM. It shows excellent preclinical in vitro ADME and safety profile. |
| FB09867 | PF-04531083 | 1079400-07-9 | PF 04531083 is a selective NaV1.8 blocker, and used for the research of neuropathic/inflammatory pain |
| FB07333 | Oxcarbazepine | 28721-07-5 | Oxcarbazepine is a voltage-gated sodium channel blocker with IC50 of 160 μM and it is used for the treatment of partial seizure. |
| FB08553 | Nicainoprol | 76252-06-7 | Nicainoprol is a sodium channels blocker which is used as an antiarrhythmic agent. |
| FB11670 | NHE3-IN-1 | 632355-68-1 | NHE3-IN-1 is a sodium/proton exchanger type 3 (NHE-3) inhibitor extracted from patent WO 2011019784 A1. |
| FB02746 | Nav1.7-IN-2 | 1332295-35-8 | Nav1.7-IN-2 is an inhibitor of voltage-gated sodium channels (Nav), in particular Nav 1.7, with IC50 of 80 nM. |
| FB01084 | Nav1.7 Inhibitor | 1355631-24-1 | Nav1.7 inhibitor is a sulfonamide derivative with potent Nav1.7 inhibition activity. |
| FB17261 | N-Me-aminopyrimidinone 9 | 1356834-62-2 | N-Me-aminopyrimidinone 9 is an improved Nav1.7 antagonist with minimal off-target hERG liability, and improved rat PK properties. |
| FB17822 | Mepivacaine | 96-88-8 | Mepivacaine is an amide-type local anesthetic agent. Mepivacaine binds to specific voltage-gated sodium ion channels in neuronal cell membranes, which inhibits both sodium influx and membrane depolarization. |
| FB02148 | Lidocaine | 137-58-6 | Lidocaine HCl is antiarrhythmic agent and used as a local anesthetic. |
| FB10640 | Lidocaine HCl | 73-78-9 | Lidocaine HCl is antiarrhythmic agent and used as a local anesthetic. |
| FB16655 | Licarbazepine | 29331-92-8 | Licarbazepine, also known as BIA-2-005; GP-47779; LIC-477; LIC-477D; TRI-477, is a voltage-gated sodium channel blocker with anticonvulsant and mood-stabilizing effects that is related to oxcarbazepine. It is an active metabolite of oxcarbazepine. In addition, an isomer of licarbazepine, eslicarbazepine ((S)-(+)-licarbazepine), is an active metabolite of eslicarbazepine acetate. Oxcarbazepine and eslicarbazepine acetate are inactive on their own, and behave instead as prodrugs to licarbazepine and eslicarbazepine, respectively, to produce their therapeutic effects. |
| FB01431 | Levobupivacaine HCl | 27262-48-2 | Levobupivacaine HCl is a local anaesthetic compound belonging to the amino amide group and a long-acting local anesthetic. |
| FB04886 | ICA-121431 | 313254-51-2 | ICA-121431 is a nanomolar potent small molecule Nav1.7 channel inhibitor with IC50 of 19 nM for rat Nav1.7, but no inhibition on human, monkey and dog Nav1.7. |
| FB03362 | GS-967 | 1262618-39-2 | GS-967 is a selective inhibitor of cardiac late sodium current (late INa ). The IC50 values in ventricular myocytes and isolated hearts are 0.13 μM and 0.21 μM. |
| FB16039 | GNE-131 | 1629063-81-5 | GNE-131 is a potent and selective inhibitor of human sodium channel NaV1.7, with an IC50 of 3 nM. |
| FB01429 | Funapide | 1259933-16-8 | Funapide is an analgesic agent which may be useful for the treatment of a variety of chronic pain conditions. |
| FB11692 | FR183998 | 239440-20-1 | FR183998 free base is a potent Na+/H+-exchange inhibitor, with IC50s of 0.3 nM, 3.1 nM and 6.5 nM by measurement of pHi change in rat lymphocytes, rat and human platelets, respectively. |
| FB02890 | Eniporide | 176644-21-6 | Eniporide is an inhibitor of Na+/H+ exchange that prevents ischemic Na+ overload. |
| FB10334 | Eleclazine HCl | 1448754-43-5 | Eleclazine HCl is a late Na+ current inhibitor with IC50 value of 0.7 μM. |
| FB16654 | EIPA | 1154-25-2 | EIPA (L593754) is a TRPP3 channel inhibitor with an IC50 of 10.5 μM. EIPA also inhibits Na+/H+-exchanger (NHE) and macropinocytosis. |
| FB16834 | DSP-2230 | 1233231-30-5 | DSP-2230 is a selective Nav1.7/Nav1.8 blocker. |
| FB04110 | Disopyramide | 3737-09-5 | Disopyramide can block sodium channel, it is a class IA antiarrhythmic drug. |
| FB00343 | Cinchocaine | 85-79-0 | Cinchocaine is amide type local anesthetic that is generally used for surface anesthesia. |
| FB09234 | Cariporide | 159138-80-4 | Cariporide is a selective inhibitor of Na+/H+ exchanger isoform 1 (NHE1) with IC50 value of 0.05 μM with cardioprotective and antiarrhythmic effects. |
| FB01772 | Carbamazepine | 298-46-4 | Carbamazepine is a blocker of sodium channel with IC50 of 131 μM in rat brain synaptosomes. It is an anticonvulsant drug. |
| FB12284 | BIX NHE1 Inhibitor | 1204329-34-9 | BIX NHE1 Inhibitor is a potent and selective NHE1 inhibitor with IC50 of 31 nM. |
| FB01462 | Benzocaine | 94-09-7 | Benzocaine, the ethyl ester of p-aminobenzoic acid (PABA), inhibits voltage-dependent sodium channels (VDSCs) on the neuron membrane and used as a local anesthetic. |
| FB09613 | Benzocaine HCl | 23239-88-5 | Benzocaine HCl is a surface anesthetic that acts by preventing transmission of impulses along nerve fibers and at nerve endings. |
| FB15309 | Benzamil HCl | 161804-20-2 | Benzamil hydrochloride is a specific blocker of sodium channel (ENaC). |
| FB10436 | Amiloride HCl | 2016-88-8 | Amiloride HCl is a selective T-type calcium channel blocker, an epithelial sodium channel blocker and a selective inhibitor of urokinase plasminogen activator (uPA)(Ki=7 μM). |
| FB10905 | AMG8379 | 1642112-31-9 | AMG8379 is a potent and selective small molecule sulfonamide antagonist of the voltage-gated sodium channel NaV1.7. |
| FB10000 | AM-0466 | 1642113-59-4 | AM-0466 shows robust pharmacodynamic activity in a NaV1.7-dependent model of histamine-induced pruritus (itch) and additionally in a capsaicin-induced nociception model of pain without any confounding effect in open field activity. |
| FB07609 | (-)-Sparteine | 90-39-1 | (-)-Sparteine is a class 1a antiarrhythmic agent and a sodium channel blocker. |