SRPK
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| FB10386 | WNK463 | 2012607-27-9 | WNK463 is a potant With-No-Lysine (WNK) kinase inhibitor with IC50s of 5/1/6/9 nM for WNK1/2/3/4. |
| FB15224 | WNK-IN-11 | 2123489-30-3 | WNK-IN-11 is a potent, selective and orally active inhibitor of WNK1 kinase with IC50 of 6 nM. |
| FB08657 | SRPIN340 | 218156-96-8 | SRPIN340 is an inhibitor of serine/arginine-rich protein kinase SRPK1 with IC50 of 0.89 μM. |
| FB13147 | SPHINX31 | 1818389-84-2 | SPHINX31 is a potent and selective inhibitor of serine/arginine-rich protein kinase 1 (SRPK1), with an IC50 of 5.9 nM. SPHINX31 inhibits phosphorylation of serine/arginine-rich splicing factor 1 (SRSF1). SPHINX31 is a potential topical therapeutic for neovascular eye disease[1]. |
| FB12616 | rac-CCT 250863 | 1364269-06-6 | rac-CCT-250863 is a potent Nek2 inhibitor. exhibiting selectivity for Nek2 over PLK1, MPS1, Cdk2 and Aurora A. |
| FB10819 | PROTAC TBK1 C3i | 2052306-13-3 | PROTAC TBK1 C3i is a potent hit (TBK1 DC50 = 12 nM, Dmax = 96%) with excellent selectivity against a related kinase IKKε, which was further used as a chemical tool to assess TBK1 as a target in mutant K-Ras cancer cells. |
| FB02251 | Pim1 AKK1-IN-1 | 1093222-27-5 | Pim1 AKK1-IN-1 is a potent multi-kinase inhibitor with Kd values of 35 nM/53 nM/75 nM/380 nM for Pim1/AKK1/MST2/LKB1 respectively and also inhibits MPSK1 and TNIK. |
| FB02676 | AR-13324 HCl | 1253952-02-1 | Netarsudil primarily targets cells in the conventional outflow tract, efficiently decreasing IOP in both human and non-human primate eyes. |
| FB12453 | NCL 00017509 | 1507367-00-1 | NCL 00017509 is a potent and reversible NIMA related kinase 2 (Nek2) inhibitor with IC50 of 56 nM. |
| FB03170 | ML281 | 1404437-62-2 | ML281 is a potent and selective serine/threonine kinase (STK33) inhibitor with IC50 of 14 nM. STK33 downregulation is toxic to KRAS-dependent cancer cell lines. |
| FB02735 | MK2-IN-1 | 1314118-92-7 | MK2-IN-1 is a potent and selecitve MAPKAPK2 (MK2) inhibitor (IC50=0.11 μM) with a non-ATP competitive binding mode. |
| FB02736 | MK2-IN-1 HCl | 1314118-94-9 | MK2-IN-1 HCl is a non-ATP competitive inhibitor of MAPKAPK2 (MK2) with IC50 of 0.11 μM. |
| FB17563 | ILK-IN-3 | 6975-75-3 | ILK-IN-3 is an integrin linked kinase inhibitor. |
| FB10259 | ILK-IN-2 | 2070015-22-2 | ILK-IN-2 is a ILK inhibitor. |
| FB02748 | ILK-IN-1 | 1333146-24-9 | ILK-IN-1 is an ILK inhibitor with IC50 of 0.6 μM. |
| FB15544 | GSK8612 | 2361659-62-1 | GSK8612 is a potent and highly selective Tank-binding Kinase-1 (TBK1) inhibitor with pIC50 of 6.8 for recombinant TBK1. |
| FB15544 | GSK8612 | 2361659-62-1 | GSK8612 is a potent and highly selective Tank-binding Kinase-1 (TBK1) inhibitor with pIC50 of 6.8 for recombinant TBK1. |
| FB06099 | Cycloheterophyllin | 36545-53-6 | Cycloheterophyllin, a natural product isolated and purified from the herbs of Artocarpus heterophyllus, exerts a concentration-dependent inhibition of neutrophil cytosolic protein kinase C (PKC) and rat brain PKC by the O2- generation in rat neutrophils, but has no effect on porcine heart protein kinase A (PKA). |
| FB08843 | Bryostatin 1 | 83314-01-6 | Bryostatin 1 is a Protein kinase C (PKC) activator that binds with high affinity (Ki = 1.35 nM). |
| FB00497 | 4μ8C | 14003-96-4 | 4μ8C is a potent and selective IRE1 Rnase inhibitor with IC50 of 76 nM. |
| FB15641 | GSK8612 | 2361659-62-1 | |
| FB15641 | GSK8612 | 2361659-62-1 | |
| FB15997 | ZT-12-037-01 | 2328073-61-4 |