p38 MAPK
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| FB06715 | VX-745 | 209410-46-8 | VX-745 is a potent and selective inhibitor of p38α with IC50 of 10 nM, 22-fold greater selectivity versus p38β and no inhibition to p38γ. |
| FB08902 | VX-702 | 745833-23-2 | VX-702 is a highly selective inhibitor of p38α MAPK with IC50 of 4 -20 nM. |
| FB11544 | UM-164 | 903564-48-7 | UM-164 is a potent dual c-Src/p38 kinase inhibitor that exhibits potent anti-TNBC activity in xenograft models. UM-164 inhibits p38 kinase and binds to an inactive c-Src conformation. |
| FB08788 | TAK-715 | 303162-79-0 | TAK-715 is a p38 MAPK inhibitor for p38α with IC50 of 7.1 nM, being 28-fold selective for p38α over p38β, showing no inhibition to p38γ/δ, JNK1, ERK1, IKKβ, MEKK1 or TAK1. |
| FB04006 | TA-02 | 1784751-19-4 | TA-02 is a p38 MAPK inhibitor with IC50 of 20 nM. |
| FB02653 | SKF-86002 | 72873-74-6 | SKF-86002 is a potent inhibitor of p38 MAP kinase with IC50 of 0.5-1 μM and inhibits LPS-induced IL-1 and TNF-α production in human monocytes (IC50 = 1 μM). |
| FB01138 | Skepinone-L | 1221485-83-1 | Skepinone-L is a selective p38 mitogen-activated protein kinase inhibitor. |
| FB17981 | SD-169 | 1670-87-7 | SD-169 is an orally active ATP-competitive inhibitor of p38α MAPK, with an IC50 of 3.2 nM. SD-169 also weakly inhibits p38β MAPK with an IC50 of 122 nM. SD-169 prevents the development and progression of diabetes by inhibiting T cell infiltration and activation. |
| FB04857 | SD-06 | 271576-80-8 | SD-06 is a p38 MAP kinase inhibitor and inhibits p38α with an IC50 value of 170 nM and inhibits LPS-stimulated TNF-release in rats(83% inhibition at 1mg/kg, po). |
| FB07038 | Scopoletin | 92-61-5 | Scopoletin has important anti-inflammatory activity by inhibiting the phosphorylation of NF-κB and p38 MAPK. |
| FB04880 | SCIO-469 | 309913-83-5 | SCIO-469 is a selective ATP-competitive p38 inhibitor with IC50 of 9 nM for p38α in vitro, about 10-fold selectivity for p38α over p38β, and at least 2000-fold selectivity for p38α over an in vitro panel of 20 other kinases, including other MAK kinases. |
| FB07423 | SB-242235 | 193746-75-7 | SB-242235 is a potent and selective p38 MAP kinase inhibitor with IC50 of 1.0 μM. |
| FB09205 | SB-203580 | 152121-47-6 | SB-203580 is a p38 MAPK inhibitor with IC50 of 0.3-0.5 μM. |
| FB06877 | SB-203580 HCl | 869185-85-3 | SB-203580 HCl is a p38 MAPK inhibitor with IC50 of 0.3-0.5 μM. |
| FB01381 | SB-202190 | 152121-30-7 | SB-202190 is a highly selective, potent and cell-permeable inhibitor of p38 MAP kinase with IC50 values of 50 nM and 100 nM for p38α and p38β respectively; also shows slightly weaker activity for BRD4 (Kd=3.4 μM). |
| FB08981 | SB-239063 | 193551-21-2 | SB 239063 is a potent, selective and oral active p38 MAPK inhibitor with IC50 of 44 nM for recombinant purified p38α. |
| FB09896 | R1487 HCl | 449808-64-4 | R1487 HCl is highly potent and highly selective inhibitors of p38α. |
| FB06790 | PH-797804 | 586379-66-0 | PH-797804 is a pyridinone inhibitor of p38α with IC50 of 26 nM, being 4-fold selective versus p38β and does not inhibit JNK2. |
| FB10199 | Pexmetinib | 945614-12-0 | Pexmetinib is a potent, orally bioavailable, dual p38 MAPK/Tie-2 inhibitor with IC50 of 4 nM/18 nM in a HEK-293 cell line. |
| FB00519 | PD169316 | 152121-53-4 | PD169316 is a potent, cell-permeable and selective p38 MAP kinase inhibitor (IC50 = 89 nM). |
| FB10321 | Pamapimod | 449811-01-2 | Pamapimod is a selective inhibitor of p38 mitogen-activated protein kinase. It inhibits p38α and p38β enzymatic activity with IC50 values of 0.014±0.002 and 0.48± 0.04 mM, respectively with no activity against p38delta or p38gamma isoforms. |
| FB01918 | p38 MAPK-IN-1 | 1006378-90-0 | p38 MAPK-IN-1 is a potent and selective inhibitor of p38 MAPK with IC50 of 68 nM, shows sustained levels, low clearance and good bioavailability. |
| FB11034 | NJK14047 | 1800576-41-3 | NJK14047 is a selective biphenyl amide p38 MAPK inhibitor which can be used in anti-viral approach targeting hepatitis B virus. |
| FB05059 | Neoechinulin A | 51551-29-2 | Neoechinulin A, a natural product isolated and purified from Aspergillus chevalieri with anti-inflammatory effect against LPS-stimulated RAW264.7 macrophages through inhibition of the NF-κB and p38 MAPK pathways, may block the phosphorylation of mitogen-activated protein kinase (MAPK) molecule p38, apoptosis signal-regulating kinase 1 (ASK-1) and nuclear translocation of nuclear factor-κB (NF-κB) p65 and p50 subunits, and ameliorate rotenone toxicity by activating a cytoprotective machinery that requires ATP and antioxidant/anti-nitration activities. |
| FB12049 | MAPK13-IN-1 | 229002-10-2 | MPAK13-IN-1 is a MAPK13 (p38δ) inhibitor, with an IC50 of 620 nM. |
| FB08925 | LY-2228820 Dimesylate | 862507-23-1 | LY2228820 is a potent p38MAPK inhibitor with IC50 of 7 nM and 3 nM for p38αMAPK and p38βMAPK. |
| FB06203 | Losmapimod | 585543-15-3 | Losmapimod is a selective, potent, and orally active p38 MAPK inhibitor with pKi of 8.1 and 7.6 for p38α and p38β, respectively. |
| FB11853 | ITX5061 | 1252679-52-9 | ITX5061 is a type II inhibitor of p38 MAPK and also an antagonist of scavenger receptor B1 (SR-B1). |
| FB06807 | FR 167653 | 158876-66-5 | FR-167653 is a selective p38 MAPK inhibitor. |
| FB12006 | FR 167653 Free Base | 158876-65-4 | FR-167653 is a selective p38 MAPK inhibitor. |
| FB01179 | Doramapimod | 285983-48-4 | Doramapimod is a highly selective p38α MAPK inhibitor with Kd of 0.1 nM, 330-fold greater selectivity versus JNK2, weak inhibition for c-RAF, Fyn and Lck, insignificant inhibition of ERK-1, SYK, IKK2, ZAP-70, EGFR, HER2, PKA, PKC, PKCα/β/γ. |
| FB16871 | Dilmapimod | 444606-18-2 | Dilmapimod is a selective p38 MAPK inhibitor. It is used in neuropathic pain and acute respiratory distress syndrome. |
| FB00319 | Deoxynivalenol | 51481-10-8 | Deoxynivalenol is a tricothecene mycotoxin and potent protein synthesis inhibitor. |
| FB10323 | Dehydrocorydaline Chloride | 10605-03-5 | Dehydrocorydaline chloride is an alkaloidal that has anti-inflammatory and anti-cancer activities. |
| FB11215 | CBS-3595 | 452056-93-8 | CBS-3595 is a dual p38α MAPK/PDE-4 inhibitor with activity against TNFα -related diseases. |
| FB07272 | BMS-582949 | 623152-17-0 | BMS-582949 is a potent and selective p38 mitogen-activated protein kinase (p38 MAPK) inhibitor with IC50 of 13 nM,inhibiting both p38 kinase activity and activation of p38. |
| FB06934 | BMS-582949 HCl | 912806-16-7 | BMS-582949 HCl is a highly selective p38α MAPK inhibitor, inhibits p38α with IC50 of 13 nM. |
| FB10727 | AZD7624 | 1095004-78-6 | AZD7624 is an inhaled p38 inhibitor, with potent anti-inflammatory activity. |
| FB12138 | AZ304 | 942507-42-8 | AZ304 is an inhibitor of BRAF and can target many kinases. The IC50s for wild type BRAF, V600E mutant BRAF and wild type CRAF are 79 nM, 38 nM and 68 nM, respectively. It can also inhibit p38 (IC50 = 6 nM) and CSF1R (IC50 = 35 nM). |
| FB00938 | Asiatic Acid | 464-92-6 | Asiatic acid is a pentacyclic triterpene isolated from a variety of plants, commonly used in wound healing by increasing collagen production. |
| FB10322 | Acumapimod | 836683-15-9 | Acumapimod is an orally active p38 MAP kinase inhibitor, with an IC50 of less than 1 μM for p38α. |