ERK
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| FB08589 | XMD8-92 | 1234480-50-2 | XMD8-92 is an inhibitor of ERK5/BMK1. The Kd values for BMK1, DCAMKL2, PLK4 and TNK1 are 80 nM, 190 nM, 600 nM and 890 nM respectively. |
| FB03222 | XMD17-109 | 1435488-37-1 | XMD17-109 is a specific ERK-5 inhibitor with an EC50 4.2 μM in HEK293 cells. |
| FB06910 | VX-11e | 896720-20-0 | VX-11e is a potent, selective, and orally bioavailable inhibitor of ERK (Extracellular Signal-Regulated Kinase) and is antitumor agent. |
| FB08121 | Ulixertinib | 869886-67-9 | Ulixertinib is a potent and reversible ERK1/ERK2 inhibitor with IC50 of < 0.3 nM for ERK2. |
| FB13040 | Ulixertinib HCl | 1956366-10-1 | Ulixertinib HCl, the salt of ulixertinib, is a reversible inhibitor of ERK1/ERK2. It can inhibit cell proliferation. |
| FB10724 | Tomatidine | 77-59-8 | Tomatidine, a natural product isolated and purified from the fruits of Lycopersicon esculentum Mill., shows antibiotic activity against small-colony variants of S. aureus, significantly suppresses the activity of ACAT and leads to reduction of atherogenesis. It also inhibits the phosphorylation of ERK, Akt, and the nuclear content of NF-κB. |
| FB17153 | TMCB | 905105-89-7 | TMCB is a dual-kinase inhibitor of both casein kinase 2 (CK2) and extracellular-signal-regulated kinase 8 (ERK8) with IC50s of 0.50 μM. |
| FB02905 | Tauroursodeoxycholate Sodium | 35807-85-3 | Tauroursodeoxycholate sodium can suppress ERK via PKCα-mediated MKP-1 induction, thus inhibiting neointimal hyperplasia of smooth muscle cells. |
| FB03033 | SCH772984 | 942183-80-4 | SCH772984 is a specific inhibitor of ERK1/2 with IC50 of 4 nM and 1 nM, respectively. |
| FB00966 | Pluripotin | 839707-37-8 | Pluripotin is a dual inhibitor of extracellular signal-regulated kinase 1 (ERK1, MAPK3) and RasGAP. It maintains embryonic stem cell (ESC) self-renewal. |
| FB11529 | MK-8353 | 1184173-73-6 | MK-8353, also known as SCH900353, is a potent and orally active ERK1/2 inhibitor and anticancer drug candidate currently being developed by Schering-Plough. MK-8353 exhibited comparable potency with SCH772984 across various preclinical cancer models. |
| FB11293 | LY3214996 | 1951483-29-6 | LY3214996 can inhibit ERK1 and ERK2 with IC50s of 5 nM. |
| FB12036 | KO-947 | 1695533-89-1 | KO-947 is a potent and selective inhibitor of ERK1/2 kinases with potential clinical utility in MAPK pathway dysregulated tumors. |
| FB04757 | Hirsutenone | 41137-87-5 | Hirsutenone, a natural product isolated and purified from the eaves of Alnus nepalensis, exhibits anti-cancer effect against prostate cancer through a direct physical inhibition of Akt1/2, attenuates adipogenesis by directly targeting PI3K and ERK during MCE in 3T3-L1 preadipocytes, underscoring the potential therapeutic application of Hirsutenone in preventing obesity, and may exert a preventive effect against microbial endotoxin lipopolysaccharide-induced inflammatory skin diseases through inhibition of ERK pathway-mediated NF-kappaB activation. Hirsutenone showed potent PL(pro) inhibitory activity with IC50 value of 4.1µM. |
| FB01456 | GDC-0994 | 1453848-26-4 | GDC-0994 is highly selective for ERK1 and ERK2, with IC50 of 1.1 nM and 0.3 nM, respectively. |
| FB10325 | GDC-0994 HCl | 2070009-58-2 | GDC-0994 HCl is highly selective for ERK1 and ERK2, with biochemical potency of 1.1 nM and 0.3 nM, respectively. |
| FB01244 | FR 180204 | 865362-74-9 | FR 180204 is a potent and selective ATP-competitive inhibitor of ERK1 and ERK2 with Ki value of 0.31 μM and 0.14 μM respectively and has IC50 values of 0.51 and 0.33 μM in enzymatic assays against ERK1 and ERK2, respectively. |
| FB17652 | SKI V | 24418-86-8 | for hPI3k. SKI V decreases formation of the mitogenic second messenger sphingosine-1-phosphate (S1P). SKI V induces apoptosis and has antitumor activity[1][2]. |
| FB02394 | ERK5-IN-1 | 1234479-76-5 | ERK5-IN-1 exhibits potent inhibition of ERK5 with cellular EC50 values of 0.19 μM and enzymatic IC50 values of 0.087 μM and of LRRK2[G2019S] with enzymatic IC50 values of 0.026μM. |
| FB04022 | DEL-22379 | 181223-80-3 | DEL-22379 inhibits ERK dimerization with IC50 of 0.5 μM. |
| FB08761 | Corynoxeine | 630-94-4 | Corynoxeine is a potent ERK1/2 inhibitor of key PDGF-BB-induced VSMC proliferation, and is a useful and prospective compound in the prevention and treatment for vascular diseases. |
| FB11874 | CC-90003 | 1621999-82-3 | CC-90003 is an irreversible inhibitor of ERK 1/2 with antitumor activity. |
| FB16047 | BCI-215 | 1245792-67-9 | BCI-215 is a hyperactivator of fibroblast growth factor signaling that is devoid of developmental toxicity and restores defective MAPK activity caused by overexpression of DUSP1 and DUSP6 in mammalian cells. BCI-215 induced rapid and sustained phosphorylation of extracellular signal-regulated kinase (ERK), p38, and c-Jun N-terminal kinase (JNK) in the absence of reactive oxygen species, and its toxicity was partially rescued by inhibition of p38 but not JNK or ERK. |
| FB17554 | BAY-885 | 2307249-33-6 | BAY-885 is a highly potent and selective ERK5 inhibitor with IC50 value of 35nM. |
| FB11537 | AZD0364 | 2097416-76-5 | AZD0364 is an ERK1 and/or ERK2 kinase for the treatment of cancer. |
| FB12240 | AX 15836 | 2035509-96-5 | AX 15836 is a potent and selective ERK5 inhibitor with IC50 of 8 nM. |
| FB10324 | APS-2-79 | 2002381-25-9 | APS-2-79 is an antagonist of MEK phosphorylation by RAF through direct binding of the KSR active site. |
| FB00747 | AG-126 | 118409-62-4 | AG 126 selectively inhibits the phosphorylation of ERK1 and ERK2 at 25-50 μM. |
| FB11113 | ADA-07 | N/A | ADA-07, a T-LAK cell-originated protein kinase (TOPK) inhibitor, is a promising chemopreventive or potential therapeutic agent against SUV-induced skin carcinogenesis that acts by specifically targeting TOPK. |
| FB18199 | ASTX029 | 2095719-92-7 |