Pim
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| FB12163 | TP-3654 | 1361951-15-6 | TP-3654 is a selective Pim kinase inhibitor with Ki values of 5nM, 239nM and 42nM for Pim-1, Pim-2 and Pim-3, respectively, as well as with an average EC50 of 67nM for cellular PIM-1 inhibition in the PIM-1/BAD overexpression system and with moderate potency to FLT3. |
| FB06138 | TCS-PIM-1-4a | 327033-36-3 | TCS-PIM-1-4a is a Pim inhibitor that blocks mTORC1 activity via activation of AMPK and kills a wide range of both myeloid and lymphoid cell lines (with IC50 values ranging from 0.8 to 40 μM). |
| FB08544 | TCS PIM-1 1 | 491871-58-0 | TCS PIM-1 1 is a potent and selective ATP-competitive Pim-1 kianse inhibitor with IC50 of 50 nM, displays good selectivity over Pim-2 and MEK1/MEK2 (IC50s > 20,000 nM). |
| FB08309 | SMI-4a | 438190-29-5 | SMI-4a is a potent inhibitor of Pim1 with IC50 of 17 nM, modestly potent to Pim-2, does not significantly inhibit any other serine/threonine- or tyrosine-kinases. |
| FB11259 | SMI-16a | 587852-28-6 | SMI-16a, the PIM1/2 Kinase inhibitor VI, controls the biological activity of PIM1/2. This small molecular inhibitor is primarily used for Phosphorylation & Dephosphorylation applications |
| FB01127 | SGI-1776 | 1025065-69-3 | SGI-1776 free base is an ATP competitive inhibitor of Pim1 with IC50 of 7 nM in a cell-free assay, 50- and 10-fold selective versus Pim2 and Pim3, also potent to Flt3 and haspin. |
| FB02251 | Pim1 AKK1-IN-1 | 1093222-27-5 | Pim1 AKK1-IN-1 is a potent multi-kinase inhibitor with Kd values of 35 nM/53 nM/75 nM/380 nM for Pim1/AKK1/MST2/LKB1 respectively and also inhibits MPSK1 and TNIK. |
| FB10111 | PIM-447 | 1210608-43-7 | PIM-447 is pan-PIM kinase inhibitor, including Moloney Murine Leukemia (PIM)1, 2, and 3 Kinase. |
| FB10112 | PIM-447 2HCl | 1820565-69-2 | PIM-447 2HCl is pan-PIM kinase inhibitor, including Moloney Murine Leukemia (PIM)1, 2, and 3 Kinase. |
| FB11283 | pan-PIM Inhibitor CS11 | 2139294-71-4 | pan-PIM inhibitor CS11 is a pan-PIM kinase inhibitor, which inhibits PIM1 and PIM2 with IC50 of 1 nM and 6 nM, respectively. |
| FB03154 | M-110 | 1395048-49-3 | M-110 is a highly selective inhibitor of PIM kinases and inhibits the proliferation of prostate cancer cell lines with IC50s of 0.6 to 0.9 μM, with no activity on normal human peripheral blood mononuclear cells up to 40 μM. |
| FB10899 | GNE-955 | 1527523-39-2 | GNE-955 is a pan-Pim inhibitor with bioavailability bioavailability and a potential hematologic–oncology use. |
| FB03202 | GDC-0339 | 1428569-85-0 | GDC-0339 is a Pim kinase inhibitor with IC50 of 43.6 nM for BaF3 PIM1. |
| FB04146 | CX-6258 | 1202916-90-2 | CX-6258 is a selective and potent Pim inhibitor with IC50 values of 5nM, 25nM and 16nM for Pim-1, Pim-2 and Pim-3 (measured by SAR assay), respectively. |
| FB10167 | CX-6258 HCl | 1353859-00-3 | CX-6258 HCl is a potent, orally efficacious pan-Pim kinase inhibitor with IC50 of 5 nM, 25 nM and 16 nM for Pim1, Pim2, and Pim3, respectively. |
| FB02788 | CX-6258 HCl H2O | 1353858-99-7 | CX-6258 HCl hydrate is the HCl hydrate form of CX-6258. CX-6258 is a selective and potent Pim inhibitor with IC50 values of 5nM, 25nM and 16nM for Pim-1, Pim-2 and Pim-3 (measured by SAR assay), respectively. |
| FB08320 | AZD1208 | 1204144-28-4 | AZD1208 is an orally bioavailable, highly selective PIM kinases inhibitor with single nanomolar potency against all three PIM kinases (IC50 of 0.4 nM, 5 nM, and 1.9 nM for Pim1, Pim2, and Pim3 in cell-free assays, respectively) and is used for treating AML. |
| FB10316 | (1S,3R,5R)-PIM447 2HCl | 2096989-57-8 | (1S,3R,5R)-PIM447 2HCl an PIM inhibitor with IC50 values of 0.095 μM for Pim1, 0.522 μM for Pim2 and 0.369 μM for Pim3. |