LRRK2
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| FB16071 | PF-06454589 | 1527473-30-8 | PF-06454589 is a potent and selective LRRK2 inhibitor. |
| FB08081 | PF-06447475 | 1527473-33-1 | PF-06447475 is a brain-penetrant, potent and selective LRRK2 inhibitor with IC50 values of 3 nM, possessing neuroprotective activity. |
| FB19570 | PF-06371900 | 1622291-81-9 | PF-06371900 is a selective LRRK2 inhibitor with IC50 value of 64nM. |
| FB10917 | MLi-2 | 1627091-47-7 | MLi-2 is a highly potent, and selective LRRK2 kinase inhibitor with central nervous system activity. |
| FB08620 | LRRK2-IN-1 | 1234480-84-2 | LRRK2-IN-1 is a potent and selective LRRK2 inhibitor with IC50 values of 6 and 13 nM for G2019S mutant and wild-type LRRK2, respectively. |
| FB00657 | JH-II-127 | 1700693-08-8 | JH-II-127 is a brain-penetrant, potent and selective LRRK2 inhibitor with IC50 values of 2.2, 6.6 and 47.7 nM for G2019S-mutant, wild-type and A2016T-mutant LRRK2, respectively. |
| FB01667 | HG-10-102-01 | 1351758-81-0 | HG-10-102-01 is a potent and selective inhibitor of wild-type LRRK2 (IC50=23.3 nM) and the G2019S mutant (IC50=3.2 nM) |
| FB08027 | GSK2578215A | 1285515-21-0 | GSK2578215A is a brain-penetrant, potent and selective LRRK2 inhibitor with IC50 values of 8.9 and 10.1 nM for LRRK2[G2019S] mutant and wild-type LRRK2, respectively. |
| FB08679 | GNE-0877 | 1374828-69-9 | GNE0877 is a highly potent, selective, and brain-penetrant aminopyrazole leucine-rich repeat kinase 2 (LRRK2) small molecule inhibitor with an IC50 of 3 nM. |
| FB03286 | GNE-9605 | 1536200-31-3 | GNE-9605 is a selective and potent LRRK2 with IC50 value of 18.7 nM. |
| FB10030 | GNE-7915 Tosylate | 2070015-00-6 | GNE-7915 tosylate is a potent, selective and brain-penetrant inhibitor of LRRK2 with an IC50 of 9 nM. |
| FB01147 | GNE-7915 | 1351761-44-8 | GNE-7915 is a brain-penetrant, potent and selective LRRK2 inhibitor with IC50 value of 9 nM. |
| FB02832 | CZC-54252 | 1191911-27-9 | CZC-54252 is a potent LRRK2 inhibitor with IC50 values of 1.28 nM and 1.85 nM for wild-type and G2019S mutant LRRK2, respecitively, possessing neuroprotective effect. |
| FB01035 | CZC-25146 | 1191911-26-8 | CZC-25146 is a potent LRRK2 inhibitor with IC50 values of 4.76 and 6.87 nM for for wild-type and G2019S mutant LRRK2, respectively. It also inhibits PLK4, GAK, TNK1, CAMKK2 and PIP4K2. |
| FB02743 | CZC-25146 HCl | 1330003-04-7 | CZC-25146 HCl is a potent, selective and metabolically stable LRRK2 inhibitor with IC50 of 4.76 nM/6.87 nM for wild type LRRK2 and G2019S LRRK2 respectively. |