| FB15487 |
TD-428
|
2334525-50-5 |
TD-428 is a PROTAC targeting on pan-BET with DC50 of 0.32nM for BRD4, consist of BET inhibitor, JQ1, as a warhead linked to CRBN modulator TD-106 as the E3 ligase ligand. |
| FB11917 |
QCA570
|
2207569-08-0 |
QCA570 is a potent PROTAC targeting on BET, consist of an optimized BET ligand QCA276 linked to a CRBN E3 ligand. |
| FB11817 |
PROTAC 11
|
2093386-22-0 |
PROTAC BET degrader-9 is PROTAC targeting on BET proteins, consist of a BET inhibitor HJB97 as the warhead ligand and Pomalidomide as CRBN ligand. |
| FB15485 |
PROTAC BET degrader-3
|
N/A |
PROTAC BET degrader-3 is PROTAC targeting on BET proteins. |
| FB15438 |
PROTAC BET degrader-2
|
2093388-33-9 |
PROTAC BET degrader-25 is PROTAC targeting on BET proteins, consist of a BET inhibitor HJB97 as the warhead ligand and a Lenalidomide analogue as the CRBN ligand. |
| FB11371 |
BETd-260
|
2093388-62-4 |
PROTAC BET Degrader 23 is a highly potent and efficacious PROTAC targeting on BET with DC50 value of 30pM for degradation of BRD4 in RS4;11 leukemia cell line. |
| FB11744 |
MZP-55
|
2010159-48-3 |
MZP-55 is a VHL-based PROTAC targeting on BET with pDC50/Dmax (%) values of 8.1/95, 7.5/93, 7.7/92, −/26 for Brd4 short, Brd4 long, Brd3 and Brd2 in HeLa cells, consist of I-BET726 as a warhead ligand linked to VHL ligand VH032. |
| FB11743 |
MZP-54
|
2010159-47-2 |
MZP-54 is a PROTAC targeting on BET, consist of a warhead I-BET726 (BET bromodomain inhibitor) linked to a VHL ligand VH032. |
| FB11915 |
MZ1
|
1797406-69-9 |
MZ1 is a PROTAC with VHL-ligand and targeting on BRD protein, with preferential selectivity to BRD4 (Kd=149nM) over BRD2 and BRD3. |
| FB11912 |
dBRD9
|
2170679-45-3 |
dBRD9 is a potent and selective PROTAC targeting on BRD9, with a PEG-linked pomalidomide |
| FB15447 |
dBRD9 2HCl
|
2341840-98-8 |
dBRD9 is a potent and selective PROTAC targeting on BRD9, with a PEG-linked pomalidomide |
| FB11875 |
dBET 6
|
1950634-92-0 |
dBET6 is an optimized and highly cell-permeable chemical degrader of BET bromodomain proteins, based on PROTAC. |
| FB11909 |
dBET1
|
1799711-21-9 |
dBET1 is a PROTAC, consisting of a BRD4-ligand JQ-1 linkerd to a cereblon E3 ligase ligand, targeting on BET bromodomain BRD4 |
| FB11768 |
AT6
|
2098836-50-9 |
AT6 is a PROTAC targeting on Brd4. |
| FB11767 |
AT 1
|
2098836-45-2 |
AT1 is a highly selective Brd4 degrader with a modified VHL ligand retained binding to VHL (Kd = 330 nM). |
| FB04023 |
ARV-825
|
1818885-28-7 |
ARV-825 is a PROTAC targeting on BRD4, consisting of a BRD4-ligand JQ-1 linked to a cereblon E3 ligase ligand Pomalidomide, with Kds values of 90nM and 28nM for affinity to BD1 and BD2. |
| FB11916 |
ARV-771
|
1949837-12-0 |
ARV-771 is a PROTAC targeting on pan-BET, containing a BRD4-binding moiety (JQ-1) and a VHL-binding moiety. |
| FB15436 |
A1874
|
2064292-12-0 |
A1874 is a nutlin-based PROTAC targeting on BRD4, consist of a BRD4-ligand JQ1 linked to a MDM2 E3 ligase ligand RG7388. |